Use of Membrane Filters in Production Technology for Sterile Drugs

I. D. Gulyakin; L. L. Nikolaeva; E. V. Sanarova; A. V. Lantsova; N. A. Oborotova

doi:10.1007/s11094-016-1394-1

Use of Membrane Filters in Production Technology for Sterile Drugs

Authors: Gulyakin I.D.¹, Nikolaeva L.L.¹, Sanarova E.V.¹, Lantsova A.V.¹, Oborotova N.A.¹
Affiliations:
1. N. N. Blokhin, Russian Oncology Research Center, Federal Agency for Scientific Organizations
Issue: Vol 50, No 1 (2016)
Pages: 33-37
Section: Drug Synthesis Methods and Manufacturing Technology
URL: https://journals.rcsi.science/0091-150X/article/view/244315
DOI: https://doi.org/10.1007/s11094-016-1394-1
ID: 244315

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Abstract

Filtration is one of the methods on which all the world’s chemical-pharmaceutical industries depend. This technological method is used for the sterilization of labile drugs and to provide them with the required properties. As a result of the introduction of strict GMP rules, most current plants use membrane filtration. We review here the main criteria used for selecting material for sterilizing filtration and provide examples of drugs whose manufacture uses this method.