Synthesis, Antimicrobial and Anticancer Evaluation of 2-Azetidinones Clubbed with Quinazolinone
- Authors: Deep A.1, Kumar P.1, Narasimhan B.1, Meng L.S.2, Ramasamy K.2, Mishra R.K.3, Mani V.3
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Affiliations:
- Faculty of Pharmaceutical Sciences, Maharshi Dayanand University
- Collaborative Drug Discovery Research Group, Faculty of Pharmacy, Campus Puncak Alam, Universiti Teknologi MARA (UiTM)
- Brain Research Laboratory, Faculty of Pharmacy, Campus Puncak Alam, Universiti Teknologi MARA (UiTM)
- Issue: Vol 50, No 1 (2016)
- Pages: 24-28
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244313
- DOI: https://doi.org/10.1007/s11094-016-1392-3
- ID: 244313
Cite item
Abstract
A novel series of 2-azetidinones clubbed with quinazolinone was synthesized using anthranilic acid. All the synthesized compounds were evaluated for their antimicrobial activity against two Gram positive bacterial strains (Bacillus subtilis and Staphylococcus aureus), one Gram negative bacterial strain (Escherichia coli) and two fungal strains (Candida albicans and Aspergillus niger). All the synthesized compounds were also screened for their anticancer activity against human breast cancer cell line, MCF-7. Results of antimicrobial and anticancer study indicate that compounds 12 and 5 (IC50 = 49.52 μM) are the most potent antimicrobial and anticancer agents, respectively.
Keywords
About the authors
Aakash Deep
Faculty of Pharmaceutical Sciences, Maharshi Dayanand University
Email: naru2000us@yahoo.com
India, Rohtak, 124001
Pradeep Kumar
Faculty of Pharmaceutical Sciences, Maharshi Dayanand University
Email: naru2000us@yahoo.com
India, Rohtak, 124001
Balasubrmanian Narasimhan
Faculty of Pharmaceutical Sciences, Maharshi Dayanand University
Author for correspondence.
Email: naru2000us@yahoo.com
India, Rohtak, 124001
Lim Siong Meng
Collaborative Drug Discovery Research Group, Faculty of Pharmacy, Campus Puncak Alam, Universiti Teknologi MARA (UiTM)
Email: naru2000us@yahoo.com
Malaysia, Bandar Puncak Alam, Selangor, 42300
Kalavathy Ramasamy
Collaborative Drug Discovery Research Group, Faculty of Pharmacy, Campus Puncak Alam, Universiti Teknologi MARA (UiTM)
Email: naru2000us@yahoo.com
Malaysia, Bandar Puncak Alam, Selangor, 42300
Rakesh Kumar Mishra
Brain Research Laboratory, Faculty of Pharmacy, Campus Puncak Alam, Universiti Teknologi MARA (UiTM)
Email: naru2000us@yahoo.com
Malaysia, Bandar Puncak Alam, Selangor, 42300
Vasudevan Mani
Brain Research Laboratory, Faculty of Pharmacy, Campus Puncak Alam, Universiti Teknologi MARA (UiTM)
Email: naru2000us@yahoo.com
Malaysia, Bandar Puncak Alam, Selangor, 42300