Method Development for Quantitative Determination of Ormustine in Biological Fluids by High Performance Liquid Chromatography with Mass-Spectrometric Detection
- Authors: Pyataev N.A.1, Petrov P.S.1, Burtasov A.A.1, Minaeva O.V.1, Kulikov O.A.1, Gurevich K.G.2, Zaborovskii A.V.2, Krasnov V.P.3, Kokorev A.V.1, Stolyarov G.S.1, Zyrnyaeva N.N.1
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Affiliations:
- N. P. Ogarev Mordovia State University
- A. I. Evdokimov Moscow State University of Medicine and Dentistry, Russian Ministry of Health
- I. Ya. Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences
- Issue: Vol 49, No 12 (2016)
- Pages: 838-842
- Section: Structure of Chemical Compounds, Methods of Analysis and Process Control
- URL: https://journals.rcsi.science/0091-150X/article/view/244304
- DOI: https://doi.org/10.1007/s11094-016-1383-4
- ID: 244304
Cite item
Abstract
An HPLC method over a Kromasil C18 reversed-phase column with mass spectrometric detection and EtOH:NH4OAc (10:90) mobile phase was developed for quantitative determination of the antitumor drug ormustine in biological fluids. The method enabled detection of both drug isomers, possessed sufficiently high sensitivity and specificity, and was linear over a wide range. The developed method was used to study ormustine pharmacokinetics in rabbits. It was found that the pharmacokinetics of both drug isomers after i.v. injection followed a two-compartment model. The elimination half-lives of ormustine-I were (3.5 ± 0.2) and (109.4 ± 22.2) min for the α- and β-phases, respectively; of ormustine-II, (3.6 ± 0.2) and (79.5 ± 21.7) min, respectively.
Keywords
About the authors
N. A. Pyataev
N. P. Ogarev Mordovia State University
Author for correspondence.
Email: dep-general@adm.mrsu.ru
Russian Federation, 68 Bol?shevistskaya St., Saransk, Mordovia, 430005
P. S. Petrov
N. P. Ogarev Mordovia State University
Email: dep-general@adm.mrsu.ru
Russian Federation, 68 Bol?shevistskaya St., Saransk, Mordovia, 430005
A. A. Burtasov
N. P. Ogarev Mordovia State University
Email: dep-general@adm.mrsu.ru
Russian Federation, 68 Bol?shevistskaya St., Saransk, Mordovia, 430005
O. V. Minaeva
N. P. Ogarev Mordovia State University
Email: dep-general@adm.mrsu.ru
Russian Federation, 68 Bol?shevistskaya St., Saransk, Mordovia, 430005
O. A. Kulikov
N. P. Ogarev Mordovia State University
Email: dep-general@adm.mrsu.ru
Russian Federation, 68 Bol?shevistskaya St., Saransk, Mordovia, 430005
K. G. Gurevich
A. I. Evdokimov Moscow State University of Medicine and Dentistry, Russian Ministry of Health
Email: dep-general@adm.mrsu.ru
Russian Federation, Moscow
A. V. Zaborovskii
A. I. Evdokimov Moscow State University of Medicine and Dentistry, Russian Ministry of Health
Email: dep-general@adm.mrsu.ru
Russian Federation, Moscow
V. P. Krasnov
I. Ya. Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences
Email: dep-general@adm.mrsu.ru
Russian Federation, 22 S. Kovalevskoi St., Ekaterinburg, 620900
A. V. Kokorev
N. P. Ogarev Mordovia State University
Email: dep-general@adm.mrsu.ru
Russian Federation, 68 Bol?shevistskaya St., Saransk, Mordovia, 430005
G. S. Stolyarov
N. P. Ogarev Mordovia State University
Email: dep-general@adm.mrsu.ru
Russian Federation, 68 Bol?shevistskaya St., Saransk, Mordovia, 430005
N. N. Zyrnyaeva
N. P. Ogarev Mordovia State University
Email: dep-general@adm.mrsu.ru
Russian Federation, 68 Bol?shevistskaya St., Saransk, Mordovia, 430005