Pharmacokinetic Study of Oxidized Dextrans

A. A. Starostenko; A. V. Troitskii; V. S. Medvedev; E. P. Gulyaeva; T. N. Bystrova; V. A. Shkurupii

doi:10.1007/s11094-016-1373-6

Pharmacokinetic Study of Oxidized Dextrans

Authors: Starostenko A.A.¹, Troitskii A.V.¹, Medvedev V.S.¹, Gulyaeva E.P.¹, Bystrova T.N.¹, Shkurupii V.A.¹
Affiliations:
1. Institute of Experimental and Clinical Medicine, Siberian Branch, Russian Academy of Medical Sciences
Issue: Vol 49, No 12 (2016)
Pages: 795-797
Section: Molecular-Biological Problems of Drug Design and Mechanism of Drug Action
URL: https://journals.rcsi.science/0091-150X/article/view/244294
DOI: https://doi.org/10.1007/s11094-016-1373-6
ID: 244294

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Abstract
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Abstract

Methods of obtaining biotinylated oxidized dextran (BTOD) and procedures for pharmacokinetic studies of BTOD and biotinylated dextran (BTD) are described. The pharmacokinetics results showed that there are no differences in principle between the oxidized and unoxidized dextrans. All studied dextrans were characterized by two-phase pharmacokinetic profiles after intraperitoneal and subcutaneous administration.

Keywords

oxidized dextran, pharmacokinetics, biotin, immunoenzymatic assay

About the authors

A. A. Starostenko

Institute of Experimental and Clinical Medicine, Siberian Branch, Russian Academy of Medical Sciences