Email this article Influence of N,N′-Substituted Piperazines on Cytolysis
- Authors: Veselkina O.S.1, Solovtsova I.L.2,3, Petrishchev N.N.2, Galebskaya L.V.2, Borovitov M.E.1, Nilov D.I.1, Solov’eva M.A.2, Vorob’ev E.A.2, Len’shina K.S.2
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Affiliations:
- Vertex Co.
- Pavlov First St. Petersburg State Medical University, MH RF
- Peter the Great St. Petersburg Polytechnic University
- Issue: Vol 49, No 11 (2016)
- Pages: 743-748
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244284
- DOI: https://doi.org/10.1007/s11094-016-1363-8
- ID: 244284
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Abstract
The hemolytic activity of N,N′-substituted piperazines and their influence on the hemolytic process initiated by radiation (red LED, 653 nm) in the presence of radachlorin (RADA-FARMA, Russia) photosensitizer and on complement-dependent hemolysis were studied. All compounds did not cause human RBC lysis in the studied concentration range (0.15 – 3.0 mM) although dose-dependent inhibition of photo-induced hemolysis that manifested as an increase of the 50% lysis time was observed. The piperazine derivatives did not substantially influence RBC lysis by the activated complement. Therefore, the antihemolytic effect of the N,N’-substituted piperazines was due to their antioxidant activity.
About the authors
O. S. Veselkina
Vertex Co.
Email: chem@folium.ru
Russian Federation, 27A 24-th Liniya, St. Petersburg, 199106
I. L. Solovtsova
Pavlov First St. Petersburg State Medical University, MH RF; Peter the Great St. Petersburg Polytechnic University
Email: chem@folium.ru
Russian Federation, 6 – 8 L’va Tolstogo St., St. Petersburg, 197022; 5 Khlopina St., St. Petersburg, 195251
N. N. Petrishchev
Pavlov First St. Petersburg State Medical University, MH RF
Email: chem@folium.ru
Russian Federation, 6 – 8 L’va Tolstogo St., St. Petersburg, 197022
L. V. Galebskaya
Pavlov First St. Petersburg State Medical University, MH RF
Email: chem@folium.ru
Russian Federation, 6 – 8 L’va Tolstogo St., St. Petersburg, 197022
M. E. Borovitov
Vertex Co.
Email: chem@folium.ru
Russian Federation, 27A 24-th Liniya, St. Petersburg, 199106
D. I. Nilov
Vertex Co.
Email: chem@folium.ru
Russian Federation, 27A 24-th Liniya, St. Petersburg, 199106
M. A. Solov’eva
Pavlov First St. Petersburg State Medical University, MH RF
Email: chem@folium.ru
Russian Federation, 6 – 8 L’va Tolstogo St., St. Petersburg, 197022
E. A. Vorob’ev
Pavlov First St. Petersburg State Medical University, MH RF
Email: chem@folium.ru
Russian Federation, 6 – 8 L’va Tolstogo St., St. Petersburg, 197022
K. S. Len’shina
Pavlov First St. Petersburg State Medical University, MH RF
Email: chem@folium.ru
Russian Federation, 6 – 8 L’va Tolstogo St., St. Petersburg, 197022
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