Email this article Analgesic Effect of Several Nonsteroidal Anti-Inflammatory Drug Nanoaerosols
- Authors: An’kov S.V.1, Tolstikova T.G.1, Onishchuk A.A.2,3, Khvostov M.V.1, Sorokina I.V.1, Baklanov A.M.2, Fomin V.M.4, Boldyrev V.V.5,3
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Affiliations:
- N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences
- V. V. Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch, Russian Academy of Sciences
- Novosibirsk State National Research University
- S. A. Khristianovich Institute of Theoretical and Applied Mechanics, Siberian Branch, Russian Academy of Sciences
- Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch, Russian Academy of Sciences
- Issue: Vol 49, No 10 (2016)
- Pages: 680-682
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244273
- DOI: https://doi.org/10.1007/s11094-016-1352-y
- ID: 244273
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Abstract
The analgesic activities of nanoaerosols of the nonsteroidal anti-inflammatory drugs indomethacin, butadion, and diclofenac were studied. It was found that nanoaerosol delivery of these drugs gave analgesic activities that were comparable to those of oral delivery 5 – 8 min after administration at doses that were 3 – 5 orders of magnitude lower.
About the authors
S. V. An’kov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences
Email: tolstiktg@nioch.nsc.ru
Russian Federation, Prosp. Akad. Lavrent’eva, 9, Novosibirsk, 630090
T. G. Tolstikova
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences
Author for correspondence.
Email: tolstiktg@nioch.nsc.ru
Russian Federation, Prosp. Akad. Lavrent’eva, 9, Novosibirsk, 630090
A. A. Onishchuk
V. V. Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch, Russian Academy of Sciences; Novosibirsk State National Research University
Email: tolstiktg@nioch.nsc.ru
Russian Federation, Ul. Institutskaya, 3, Novosibirsk, 630090; Ul. Pirogova, 2, Novosibirsk, 630090
M. V. Khvostov
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences
Email: tolstiktg@nioch.nsc.ru
Russian Federation, Prosp. Akad. Lavrent’eva, 9, Novosibirsk, 630090
I. V. Sorokina
N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences
Email: tolstiktg@nioch.nsc.ru
Russian Federation, Prosp. Akad. Lavrent’eva, 9, Novosibirsk, 630090
A. M. Baklanov
V. V. Voevodsky Institute of Chemical Kinetics and Combustion, Siberian Branch, Russian Academy of Sciences
Email: tolstiktg@nioch.nsc.ru
Russian Federation, Ul. Institutskaya, 3, Novosibirsk, 630090
V. M. Fomin
S. A. Khristianovich Institute of Theoretical and Applied Mechanics, Siberian Branch, Russian Academy of Sciences
Email: tolstiktg@nioch.nsc.ru
Russian Federation, Ul. Institutskaya, 4/1, Novosibirsk, 630090
V. V. Boldyrev
Institute of Solid State Chemistry and Mechanochemistry, Siberian Branch, Russian Academy of Sciences; Novosibirsk State National Research University
Email: tolstiktg@nioch.nsc.ru
Russian Federation, Ul. Kutateladze, 18, Novosibirsk, 630090; Ul. Pirogova, 2, Novosibirsk, 630090
