Synthesis and Antibacterial and Immunobiological Activity of Ethyl-1-(4-Aminosulfonylphenyl)-5-Aryl-3-Hydroxy-2-Oxo-3-Pyrroline-4-Carboxylates
- Authors: Gein V.L.1, Bobrovskaya O.V.1, Odegova T.F.1, Krylova I.V.2, Gein O.N.1, Sopova E.É.3, Gein S.V.3
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Affiliations:
- Perm State Pharmaceutical Academy, RF Ministry of Health
- Perm State National Research University
- Perm State Medical Academy
- Issue: Vol 49, No 10 (2016)
- Pages: 677-679
- Section: Article
- URL: https://journals.rcsi.science/0091-150X/article/view/244272
- DOI: https://doi.org/10.1007/s11094-016-1351-z
- ID: 244272
Cite item
Abstract
A series of ethyl-1-(4-aminosulfonylphenyl)-5-aryl-3-hydroxy-2-oxo-3-pyrroline-4-carboxylates were synthesized via a three-component reaction of sodium diethyloxalylacetate and a mixture of an aromatic aldehyde and 4-aminobenzenesulfonamide. The structures of the compounds were established using IR and PMR spectroscopy and mass spectrometry. The antibacterial and immunobiological activities of the synthesized compounds were studied.
About the authors
V. L. Gein
Perm State Pharmaceutical Academy, RF Ministry of Health
Author for correspondence.
Email: geinvl48@mail.ru
Russian Federation, Ul. Polevaya, 2, Perm, 614990
O. V. Bobrovskaya
Perm State Pharmaceutical Academy, RF Ministry of Health
Email: geinvl48@mail.ru
Russian Federation, Ul. Polevaya, 2, Perm, 614990
T. F. Odegova
Perm State Pharmaceutical Academy, RF Ministry of Health
Email: geinvl48@mail.ru
Russian Federation, Ul. Polevaya, 2, Perm, 614990
I. V. Krylova
Perm State National Research University
Email: geinvl48@mail.ru
Russian Federation, Perm, 614990
O. N. Gein
Perm State Pharmaceutical Academy, RF Ministry of Health
Email: geinvl48@mail.ru
Russian Federation, Ul. Polevaya, 2, Perm, 614990
E. É. Sopova
Perm State Medical Academy
Email: geinvl48@mail.ru
Russian Federation, Perm, 614000
S. V. Gein
Perm State Medical Academy
Email: geinvl48@mail.ru
Russian Federation, Perm, 614000