Determination of 6-Nitro-7-(4'-Nitrophenyl)-5-Ethyl-4,7-Dihydropyrazolo[1,5-a]Pyrimidine-3-Carboxylate as a Potential Antitumor Agent by Voltammetry
- Авторлар: Mozharovskaia P.1, Ivoilova A.1, Terekhova A.1, Tsmokalyuk A.1, Ivanova A.1, Kozitsina A.1, Rusinov V.1,2
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Мекемелер:
- Ural Federal University named after the first President of Russia B.N. Yeltsin
- Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences
- Шығарылым: Том 78, № 3 (2023)
- Беттер: 260-267
- Бөлім: ОРИГИНАЛЬНЫЕ СТАТЬИ
- URL: https://journals.rcsi.science/0044-4502/article/view/136017
- DOI: https://doi.org/10.31857/S0044450223020081
- EDN: https://elibrary.ru/FUUGSE
- ID: 136017
Дәйексөз келтіру
Аннотация
6-Nitro-7-(4'-nitrophenyl)-5-ethyl-4,7-dihydropyrazolo[1,5-a]pyrimidine-3-carboxylate (1) is one of promising antitumor compounds exhibiting biological activity against type 2 casein kinase, which is currently considered as a promising target in chemotherapy. Using the method of cyclic voltammetry, it was shown that the electrochemical activity of compound 1 in a mixed solution of Tris-HCl and ethanol (1 : 1) at pH 7.5 on a glassy-carbon electrode is due to the electrochemical reduction of the nitro group conjugated with the phenyl ring. A method was developed for the determination of compound 1 by direct cathodic square-wave voltammetry. The linearity region of the corresponding calibration curve obtained in a solution of a mixture of Tris-HCl and ethanol (1 : 1) at pH 7.5 is 5–500 mg/L (R2 = 0.988), the limit of detection is 0.8 mg/L, the limit of quantification is 2.4 mg/L. The accuracy of the developed procedure is close to 100%, the relative standard deviation is 1.4%.
Авторлар туралы
P. Mozharovskaia
Ural Federal University named after the first President of Russia B.N. Yeltsin
Email: pnmozharovskaia@urfu.ru
620002, Yekaterinburg, Russia
A. Ivoilova
Ural Federal University named after the first President of Russia B.N. Yeltsin
Email: pnmozharovskaia@urfu.ru
620002, Yekaterinburg, Russia
A. Terekhova
Ural Federal University named after the first President of Russia B.N. Yeltsin
Email: pnmozharovskaia@urfu.ru
620002, Yekaterinburg, Russia
A. Tsmokalyuk
Ural Federal University named after the first President of Russia B.N. Yeltsin
Email: pnmozharovskaia@urfu.ru
620002, Yekaterinburg, Russia
A. Ivanova
Ural Federal University named after the first President of Russia B.N. Yeltsin
Email: pnmozharovskaia@urfu.ru
620002, Yekaterinburg, Russia
A. Kozitsina
Ural Federal University named after the first President of Russia B.N. Yeltsin
Email: pnmozharovskaia@urfu.ru
620002, Yekaterinburg, Russia
V. Rusinov
Ural Federal University named after the first President of Russia B.N. Yeltsin; Postovskii Institute of Organic Synthesis, Ural Branch, Russian Academy of Sciences
Хат алмасуға жауапты Автор.
Email: pnmozharovskaia@urfu.ru
620002, Yekaterinburg, Russia; 620137, Yekaterinburg, Russia
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