Pyoderma gangrenosum mimicking granulomatosis with polyangiitis: case report and riview of the literature
- Authors: Olisova O.Y.1, Teplyuk N.P.1, Grabovskaya O.V.1, Kusraeva D.T.1, Kayumova L.N.1, Bobkova A.E.1, Varshavsky V.A.1, Komleva L.F.2, Petrenko E.V.2, Bobrova K.Y.2
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Affiliations:
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- Kaluga Region Clinical Dermatovenereologic Dispensary
- Issue: Vol 99, No 2 (2023)
- Pages: 70-79
- Section: CLINICAL CASE REPORTS
- URL: https://journals.rcsi.science/0042-4609/article/view/131359
- DOI: https://doi.org/10.25208/vdv1386
- ID: 131359
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Abstract
Pyoderma gangrenosum is an autoinflammatory neutrophilic dermatosis. Diagnosis of the disease remains a difficult task to date, due to the lack of a standard of examination and differential diagnostic signs. The primary elements in the development of PG may be papules, pustules or bullae the dissection of which subsequently leads to the formation of ulcers with irregular, violaceous, undermined borders. In rare cases, the diagnosis of the disease can also be complicated by the rapid development of internal organs damage symptoms, which must be regarded as extracutaneous manifestations of PG. Extracutaneous lesions can occur before, during or after the appearance of skin rashes, and the detection of sterile neutrophil infiltrates in the defeat of internal organs confirm the concept of PG as a multisystemic disease. The presented case of a rare course of PG with multiple skin lesions and extracutaneous manifestations, simulating systemic vasculitis, emphasizes the importance of a detailed examination of patients in order to make a correct diagnosis and prescribe timely adequate treatment.
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##article.viewOnOriginalSite##About the authors
Olga Yu. Olisova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: olisova_olga@mail.ru
ORCID iD: 0000-0003-2482-1754
SPIN-code: 2500-7989
MD, Dr. Sci. (Med.), Professor, Corresponding Member of the Russian Academy of Sciences
Russian Federation, 4/1 Bolshaya Pirogovskaya street, 119991 MoscowNatalia P. Teplyuk
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: Teplyukn@gmail.com
ORCID iD: 0000-0002-5800-4800
SPIN-code: 8013-3256
Russian Federation, 4/1 Bolshaya Pirogovskaya street, 119991 Moscow
Olga V. Grabovskaya
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: olgadoctor2013@yandex.ru
ORCID iD: 0000-0002-5259-7481
SPIN-code: 1843-1090
MD, Cand. Sci. (Med.), Professor
Russian Federation, 4/1 Bolshaya Pirogovskaya street, 119991 MoscowDiana T. Kusraeva
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: kysra1992@mail.ru
ORCID iD: 0000-0002-5633-7986
SPIN-code: 1478-3503
Postgraduate Student
Russian Federation, 4/1 Bolshaya Pirogovskaya street, 119991 MoscowLyailya N. Kayumova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: avestohka2005@inbox.ru
ORCID iD: 0000-0003-0301-737X
SPIN-code: 4391-9553
MD, Cand. Sci. (Med.)
Russian Federation, 4/1 Bolshaya Pirogovskaya street, 119991 MoscowAnna E. Bobkova
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: anya_bobkova98@mail.ru
ORCID iD: 0000-0003-3611-0917
Clinical Resident
Russian Federation, 4/1 Bolshaya Pirogovskaya street, 119991 MoscowVladimir A. Varshavsky
I.M. Sechenov First Moscow State Medical University (Sechenov University)
Email: vavarsh@gmail.com
ORCID iD: 0000-0002-5855-3092
MD, Dr. Sci. (Med.), Professor
Russian Federation, 4/1 Bolshaya Pirogovskaya street, 119991 MoscowLyudmila F. Komleva
Kaluga Region Clinical Dermatovenereologic Dispensary
Email: komlevalf@okvd-kaluga.ru
ORCID iD: 0000-0002-7855-8480
Dermatovenereologist
Russian Federation, 33, Pervomayskaya st., KalugaEkaterina V. Petrenko
Kaluga Region Clinical Dermatovenereologic Dispensary
Email: Petrenko.ev@gmail.com
ORCID iD: 0000-0001-5296-5734
MD, Cand. Sci. (Med.), Dermatovenereologist
Russian Federation, 33, Pervomayskaya st., KalugaKsenia Yu. Bobrova
Kaluga Region Clinical Dermatovenereologic Dispensary
Author for correspondence.
Email: Bobrovaku@okvd-kaluga.ru
ORCID iD: 0000-0003-3645-0487
Dermatovenereologist
Russian Federation, 33, Pervomayskaya st., KalugaReferences
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