Peculiarities of Mild Asthma in Russia: the Results of SYGMA2 Study
- 作者: Aisanov Z.1, Avdeev S.2, Arkhipov V.3, Belevsky A.1, Voznesenskiy N.4
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隶属关系:
- Pirogov Russian National Research Medical University
- Sechenov First Moscow State Medical University (Sechenov University)
- Russian Medical Academy of Continuous Professional Education
- Severtsov Institute of Ecology and Evolution
- 期: 卷 93, 编号 4 (2021)
- 页面: 449-455
- 栏目: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/71227
- DOI: https://doi.org/10.26442/00403660.2021.04.200812
- ID: 71227
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Aim. Patients with mild asthma may experience severe exacerbations. This analysis was conducted to investigate regional peculiarities of mild asthma population in Russia.
Materials and methods. The SYGMA2 is a double-blind multinational study involving adult patients with mild asthma (n=4176). We conducted an open-label descriptive analysis of the baseline characteristics of the Russian group (n=579) of SYGMA2 trial comparing to SYGMA2 population from other countries. The subanalysis was descriptive only, and no hypothesis were tested.
Results. The Russian population of patients with mild asthma was comparable to the rest of countries in terms of demographic characteristics, smoking status and duration of asthma. The spirometric parameters in the Russian group was slightly worse than in the other population. At the study entry 48% of Russian patients had symptom control on maintenance therapy, but 52% were uncontrolled on short-acting bronchodilators. While in other countries this ratio was inverse (55/45%). More patients with mild asthma in the Russian group had at least one severe exacerbation in the previous year (30.1% vs 20.7% in other countries).
Conclusion. We revealed a delayed prescription of controller therapy and overuse of short-acting bronchodilators in the Russian group of mild asthma patients, that may increase risk of asthma non-control and severe exacerbation.
作者简介
Zaurbek Aisanov
Pirogov Russian National Research Medical University
编辑信件的主要联系方式.
Email: aisanov@mail.ru
ORCID iD: 0000-0002-4044-674X
д.м.н., проф. каф. пульмонологии
俄罗斯联邦, MoscowSergey Avdeev
Sechenov First Moscow State Medical University (Sechenov University)
Email: aisanov@mail.ru
ORCID iD: 0000-0002-5999-2150
чл.-кор. РАН, д.м.н., проф., зав. каф. пульмонологии
俄罗斯联邦, MoscowVladimir Arkhipov
Russian Medical Academy of Continuous Professional Education
Email: aisanov@mail.ru
ORCID iD: 0000-0002-5671-3478
д.м.н., проф. каф. клинической фармакологии и терапии
俄罗斯联邦, MoscowAndrey Belevsky
Pirogov Russian National Research Medical University
Email: aisanov@mail.ru
ORCID iD: 0000-0001-6050-724X
д.м.н., проф., зав. каф. пульмонологии
俄罗斯联邦, MoscowNikolay Voznesenskiy
Severtsov Institute of Ecology and Evolution
Email: aisanov@mail.ru
ORCID iD: 0000-0001-8216-417X
к.м.н., вед. инженер
俄罗斯联邦, Moscow参考
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