Peripheral nervous system lesion in systemic vasculitis - issues of diagnosis and treatment
- 作者: Golovach I1, Yehudina Y.2
-
隶属关系:
- Feofaniya Clinical hospital State Management of Affairs
- Clinic of modern rheumatology
- 期: 卷 91, 编号 12 (2019)
- 页面: 63-69
- 栏目: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/33743
- DOI: https://doi.org/10.26442/00403660.2019.12.000206
- ID: 33743
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Vasculitis is a clinically diverse group of diseases with histopathological signs of blood vessel inflammation, which contributes to vascular damage and ischemic damage to the affected tissues. Vasculitic neuropathy is a common complication of the primary systemic vasculitides, such as polyartertis nodosa and antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis, systemic diseases of the connective tissue - systemic lupus erythematosus and Sjogren syndrome, vasculitis associated with infection, most often viral hepatitis C and B and non - systemic vasculitis neuropathy. Vessels of medium and small caliber are involved in the pathological process in these diseases. With all vasculitis, except for those caused by the direct effect of the infectious trigger on the blood vessel walls, the main pathogenetic mechanism is an autoimmune process with the development of vasa nervorum vasculitis - small arteries and vessels that supply peripheral nerves, and the outcome - nerve ischemia. The classic clinical presentation is an acute or subacute painful multifocal neuropathy that has a predilection for the lower extremities, affects two or more named nerves, and progresses in a step wise manner. However, vasculitic neuropathy can manifest in a variety of ways, including asymmetric polyneuropathies and distal symmetric sensory neuropathies, and it also can be slowly progressive, particularly in cases of nonsystemic vasculitic neuropathy (NSVN), a form of vasculitis that clinically remains restricted to peripheral nerves. Nerve biopsy can help establish the diagnosis of a systemic vasculitis, particularly when other organ involvement is not clinically apparent, and is required for diagnosis of NSVN. Neuropathy due to systemic vasculitis should be treated in accordance with the recommendations for the treatment of the underlying disease. In NSVH, the main medicine of choice are glucocrticoids, and in severe/progressive cases, pulse therapy with cyclophosphamide.
作者简介
I Golovach
Feofaniya Clinical hospital State Management of AffairsKyiv, Ukraine
Ye Yehudina
Clinic of modern rheumatologyKyiv, Ukraine
参考
- Jennette J.C, Falk R.J, Bacon P.A, et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013;65(1):1-11. doi: 10.1002/art.37715
- Шостак Н.А., Клименко А.А. Системные васкулиты: новое в классификации, диагностике и лечении. Клиницист. 2015;(2):8-12. doi: 10.17 650/1818-8338-2015-9-2-8-12
- Collins M.P, Dyck P.J.B, Gronseth G.S, et al. Peripheral Nerve Society. Peripheral Nerve Society Guideline on the classification, diagnosis, investigation, and immunosuppressive therapy of nonsystemic vasculitic neuropathy: executive summary. J Peripher Nerv Syst. 2010;15:176-84. doi: 10.1111/j.1529-8027.2010.00281.x
- Gorson K.C. Vasculitic neuropathies: an update. Neurologist 2007;13(1):12-9. doi: 10.1097/01.nrl.0000252942.14928.17
- Imboden J.B. Involvement of the peripheral nervous system in polyarteritis nodosa and antineutrophil cytoplasmic antibodies - associated vasculitis. Rheum Dis Clin North Am. 2017;43(4):633-9. doi: 10.1016/j.rdc.2017.06.011
- Cattaneo L, Chierici E, Pavone L, et al. Peripheral neuropathy in Wegener’s granulomatosis, Churg-Strauss syndrome and microscopic polyangiitis. J Neurol Neurosurg Psychiatry. 2007;78(10):1119-23. doi: 10.1136/jnnp.2006.111013
- Vrancken A.F.J.E, Said G. Vasculitic neuropathy. Handb Clin Neurol. 2013;115:463-83. doi: 10.1016/B978-0-444-52902-2.00026-6
- Cottin V, Bel E, Bottero P, et al. Revisiting the systemic vasculitis in eosinophilic granulomatosis with polyangiitis (Churg-Strauss): a study of 157 patients by the Groupe d’Etudes et de Recherche sur les Maladies Orphelines Pulmonaires and the European Respiratory Society Task - force on eosinophilic granulomatosis with polyangiitis (Churg-Strauss). Autoimmun Rev. 2017;16(1):1-9. doi: 10.1016/ j.autrev.2016.09.018
- Iudici M, Pagnoux C, Quartier P, et al. French Vasculitis Study Group. Childhood - versus adult - onset ANCA-associated vasculitides: a nested, matched case - control study from the French Vasculitis Study Group Registry. Autoimmun Rev. 2018;17(2):108-14. doi: 10.1016/j.autrev.2017.11.014
- Gwathmey K.G, Burns T.M, Collins M.P, Dyck P.J. Vasculitic neuropathies. Lancet Neurol. 2014;13(1):67-82. doi: 10.1016/S1474-4422(13)70236-9
- Pagnoux C, Seror R, Henegar C, et al., French Vasculitis Study Group. Clinical features and outcomes in 348 patients with polyarteritis nodosa: a systematic retrospective study of patients diagnosed between 1963 and 2005 and entered into the French Vasculitis Study Group Database. Arthritis Rheum. 2010;62(2):616-26. doi: 10.1002/art.27240
- Bouiller K, Audia S, Devilliers H, et al. Etiologies and prognostic factors of leukocytoclastic vasculitis with skin involvement: a retrospective study in 112 patients. Medicine (Baltimore). 2016;95(28):e4238. doi: 10.1097/MD.0000000000004238
- Collins M.P. The vasculitic neuropathies: an update. Curr Opin Neurol. 2012;25(5):573-85. doi: 10.1097/WCO.0b013e3283580432
- Morozumi S, Koike H, Tomita M, et al. Spatial distribution of nerve fiber pathology and vasculitis in microscopic polyangiitis - associated neuropathy. J Neuropathol Exp Neurol. 2011;70(3):340-8. doi: 10.1097/NEN.0b013e3182172290
- Naddaf E, Dyck P.J. Vasculitic neuropathies. Curr Treat Options Neurol. 2015;17(10):374. doi: 10.1007/s11940-015-0374-1
- Hadden R.D, Collins M.P, Živković S.A, et al. Vasculitic peripheral neuropathy: case definition and guidelines for collection, analysis, and presentation of immunisation safety data. Vaccine. 2017;35(1):1567-78. doi: 10.1016/j.vaccine.2015.11.047
- Collins M.P, Hadden R.D. The nonsystemic vasculitic neuropathies. Nat Rev Neurol. 2017;13:302-16. doi: 10.1038/nrneurol.2017.42
- Graf J, Imboden J. Vasculitis and peripheral neuropathy. Curr Opin Rheumatol. 2019;31:40-5. doi: 10.1097/BOR.0000000000000559
- De Virgilio A, Greco A, Magliulo G, Gallo A, Ruoppolo G, Conte M, et al. Polyarteritis nodosa: A contemporary overview. Autoimmun Rev. 2016;15(6):564-70. doi: 10.1016/j.autrev.2016.02.015
- Lacomis D, Zivkovic S.A. Approach to vasculitic neuropathies. J Clin Neuromusc Dis. 2007;9:265-76. doi: 10.1097/CND.0b013e31815202b3
- Игнатова Т.М., Козловская Л.В., Гордовская Н.Б., Чернова О.А., Милованова С.Ю., Новиков П.И., Некрасова Т.П., Бекетова Т.В., Мухин Н.А. Криоглобулинемический васкулит, ассоциированный с вирусом гепатита С: 20-летний опыт лечения. Терапевтический архив. 2017;89(5):46-52. doi: 10.17116/ ter-arkh201789546-52
- Maneiro J, Lopez-Canoa N, Salgado E, Gomez-Reino J. Maintenance therapy of lupus nephritis with mycophenolate or azathioprine: systematic review and meta - analysis. Rheumatology (Oxford). 2014;53:834-8. doi: 10.1093/rheumatology/ket429
- Stone J, Merkel P, Spiera R, et al. Rituximab versus cyclophosphamide for ANCA-associated vasculitis. N Engl J Med. 2010;363:221-32. doi: 10.1056/NEJMoa0909905
- Blaes F. Diagnosis and therapeutic options for peripheral vasculitic neuropathy. Ther Adv Musculoskelet Dis. 2015;7(2):45-55. doi: 10.1177/1759720X14566617
- Chiche L, Bataille S, Kaplanski G, Jourde N. The place of immunotherapy in the management of HCV-induced vasculitis: an update. Clin Dev Immunol. 2012:315167. doi: 10.1155/2012/315167
- Wludarczyk A, Szczeklik W. Neurological manifestations in ANCA-associated vasculitis - assessment and treatment. Exp Rev Neurother. 2016;16(8):861-63. doi: 10.1586/14737175.2016.1165095
- Lubana S.S, Singh N, Sanelli-Russo S, Abrudescu A. Non-Systemic Vasculitic Neuropathy: An Enigmatic Clinical Entity. Am J Case Rep. 2015;16:449-53. doi: 10.12659/AJCR.894601
- Collins M.P, Periquet-Collins I. Nonsystemic vasculitic neuropathy: up - date on diagnosis, classification, pathogenesis, and treatment. Front Neurol Neurosci. 2009;26:26-66. doi: 10.1159/000212368
- Uceyler N, Geng A, Reiners K, et al. Nonsystemic vasculitic neuropathy: single - center follow - up of 60 patients. J Neurol. 2015;262:2092-100. doi: 10.1007/s00415-015-7813-5
- De Vita S, Quartuccio L, Isola M, et al. A randomized controlled trial of rituximab for the treatment of severe cryoglobulinemic vasculitis. Arthritis Rheum. 2012;64:843-53. doi: 10.1002/art.34331