Genetic polymorphisms coding hemostasis protein synthesis and venous thromboembolic complications in Moscow population
- 作者: Vorob'eva N.1, Khasanova Z1, Konovalova N1, Postnov A1, Kirienko A.2, Panchenko E.1, Vorobieva N3, Khasanova Z3, Konovalova N3, Postnov A3, Kirienko A4, Panchenko E3
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隶属关系:
- ФГУ Российский кардиологический научно-производственный комплекс
- РГМУ им. Н. И. Пирогова
- Russian Cardiological Research Center, Moscow
- N.I. Pirogov Second Russian Medical University, Moscow
- 期: 卷 83, 编号 3 (2011)
- 页面: 48-52
- 栏目: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/30831
- ID: 30831
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Material and methods. A total of 111 patients with the history of deep vein thrombosis and/or pulmonary artery thromboembolism were examined. The control groups consisted of 197 healthy volunteers. Eleven polymorphisms in 7 genes coding hemostasis protein synthesis were investigated: V Leiden G1691A factor, G20210A prothrombin, C677T methylentetrahydrofolatreductase, A1298C methylentetrahydrofolatreductase, type 1 plasminogen activator inhibitor, 4G/5G promoter region, XIII V34L coagulation factor, IIIa L33P thrombocytic glycoprotein, C282Y hemochromatosis, G854A beta-fibrinogen, G455A beta-fibrinogen, C249T beta-fibrinogen.
Results. Polymorphisms of the genes coding hemostasis protein synthesis were detected in all the patients and controls. The carriage occurred with the same frequency, respectively. By one-factor analysis, VTEC was associated with carriage of three heterozygous genotypes: V Leiden factor (p < 0.001), prothrombin (p = 0.052) and hemochromatosis (p = 0.048). Multifactor regression analysis has shown that only carriage of heterozygous polymorphism of V Leiden factor gene is a genetic prognostic factor of VTEC in Moscow population (p = 0.001, RR = 7.00, 95% CI 2.2-21.7).
Conclusion. Genetic polymorphisms coding hemostasis protein synthesis are not a rare finding in Moscow population and occur in all the examinees (both patients and healthy subjects) in different combinations. Only carriage of V Leiden factor heterozygous genotype is a genetic prognostic factor of VTEC in Moscow population and is associated with a 7-fold increase of VTEC risk.
作者简介
Natal'ya Vorob'eva
ФГУ Российский кардиологический научно-производственный комплекс
Email: natalyavorobjeva@mail.ru
Тел.: 8-915-192-22-78; ФГУ Российский кардиологический научно-производственный комплекс
Z Khasanova
ФГУ Российский кардиологический научно-производственный комплексФГУ Российский кардиологический научно-производственный комплекс
N Konovalova
ФГУ Российский кардиологический научно-производственный комплексФГУ Российский кардиологический научно-производственный комплекс
A Postnov
ФГУ Российский кардиологический научно-производственный комплексФГУ Российский кардиологический научно-производственный комплекс
Aleksandr Kirienko
РГМУ им. Н. И. Пирогова
Email: phlebo-union@mtu-net.ru
д-р мед. наук, проф. каф. факультетской хирургии РГМУ им. Н. И. Пирогова, тел.: 8-495-236-02-49; РГМУ им. Н. И. Пирогова
Elizaveta Panchenko
ФГУ Российский кардиологический научно-производственный комплекс
Email: lizapanchenko@mail.ru
д-р мед. наук, проф., РКНПК Минздравсоцразвития, отдел ангиологии, лаб. клинических проблем атеротромбоза, рук. лаб., тел.: 8-495-414-63-04; ФГУ Российский кардиологический научно-производственный комплекс
N Vorobieva
Russian Cardiological Research Center, MoscowRussian Cardiological Research Center, Moscow
Z Khasanova
Russian Cardiological Research Center, MoscowRussian Cardiological Research Center, Moscow
N Konovalova
Russian Cardiological Research Center, MoscowRussian Cardiological Research Center, Moscow
A Postnov
Russian Cardiological Research Center, MoscowRussian Cardiological Research Center, Moscow
A Kirienko
N.I. Pirogov Second Russian Medical University, MoscowN.I. Pirogov Second Russian Medical University, Moscow
E Panchenko
Russian Cardiological Research Center, MoscowRussian Cardiological Research Center, Moscow
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