Type 2 diabetes mellitus and coronary artery disease: features of perfusion volume computed tomography of the heart in a pharmacological test with adenosine triphosphate
- 作者: Soboleva G.1, Minasyan A.1, Gaman S.1, Rogoza A.1, Molina L.2, Soboleva T.3, Shariya M.1,3, Ternovoy S.1,3, Karpov Y.1
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隶属关系:
- Chazov National Medical Research Center of Cardiology
- Endocrinological Dispensary
- Sechenov First Moscow State Medical University (Sechenov University)
- 期: 卷 95, 编号 4 (2023)
- 页面: 309-315
- 栏目: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/132921
- DOI: https://doi.org/10.26442/00403660.2023.04.202158
- ID: 132921
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Aim. To study myocardial perfusion in patients with coronary artery disease (CAD) with and without type 2 diabetes mellitus (DM) using volumetric computed tomography (VCT) of the heart with a pharmacological test with adenosine triphosphate (ATP).
Materials and methods. The study included 93 patients, of which 18 had CAD with DM, and 50 had CAD without DM. All patients underwent one of the stress tests, cardiac VCT with ATP test, invasive coronary angiography, or CT coronary angiography. Left ventricle (LV) myocardial perfusion was evaluated for hypoperfusion zones and the calculation of semi-quantitative indices: decrease of LV myocardial density, LV myocardial perfusion index, transmural perfusion coefficient, and our proposed new indicator – myocardial perfusion reserve (MPR).
Results. The MPR index value in the hypoperfusion zones in patients with CAD and DM was 0.64 [0.62–0.66], in patients with CAD without diabetes 0.65 [0.63–0.66]; p=0.4; the value of the transmural perfusion coefficient in the areas of abnormal LV myocardial perfusion in patients with CAD and DM was 0.81 [0.80–0.86] versus 0.83 [0.80–0.85] in patients with CAD without DM (p=0.6). More hypoperfusion segments were observed in patients with CAD and DM (33.3%) compared to those without DM (14%; p=0.029). The MPR index in the hypoperfusion zones in patients with CAD with intact coronary arteries (CA) and DM was 0.56 [0.54–0.60] versus 0.55 [0.54–0.62] in patients with CAD with intact CA without DM; p=0.2.
Conclusion. In patients with CAD and type 2 DM, according to the VCT with ATP test, more foci hypoperfusion areas were detected, regardless of the severity of coronary artery involvement, compared with patients with CAD without DM, which may be due to the microangiopathy in the myocardium. The similarity of the MPR parameters in the hypoperfusion zones associated with hemodynamic stenosis of the CA and with intact CAs indicates the ischemic genesis of these zones.
For citation: Soboleva GN, Minasyan AA, Gaman SA, Rogoza AN, Molina LP, Soboleva TV, Shariya MA, Ternovoy SK, Karpov YuA. Type 2 diabetes mellitus and coronary artery disease: features of perfusion volume computed tomography of the heart in a pharmacological test with adenosine triphosphate. Terapevticheskii Arkhiv (Ter. Arkh.). 2023;95(4):309–315. DOI: 10.26442/00403660.2023.04.202158
作者简介
Galina Soboleva
Chazov National Medical Research Center of Cardiology
编辑信件的主要联系方式.
Email: soboleva_galina@inbox.ru
ORCID iD: 0000-0002-6484-5884
д-р мед. наук, вед. науч. сотр. отд. ангиологии Научно-исследовательского института клинической кардиологии им. А.Л. Мясникова
俄罗斯联邦, MoscowArevik Minasyan
Chazov National Medical Research Center of Cardiology
Email: soboleva_galina@inbox.ru
ORCID iD: 0000-0002-9695-0881
аспирант отд. ангиологии Научно-исследовательского института клинической кардиологии им. А.Л. Мясникова
俄罗斯联邦, MoscowSvetlana Gaman
Chazov National Medical Research Center of Cardiology
Email: soboleva_galina@inbox.ru
ORCID iD: 0000-0002-2165-3911
канд. мед. наук, ст. науч. сотр. отд. томографии диагностики Научно-исследовательского института клинической кардиологии им. А.Л. Мясникова
俄罗斯联邦, MoscowAnatoly Rogoza
Chazov National Medical Research Center of Cardiology
Email: soboleva_galina@inbox.ru
ORCID iD: 0000-0002-0543-3089
д-р биол. наук, проф., и. о. рук. отд. новых методов диагностики Научно-исследовательского института клинической кардиологии им. А.Л. Мясникова
俄罗斯联邦, MoscowLiudmila Molina
Endocrinological Dispensary
Email: soboleva_galina@inbox.ru
ORCID iD: 0000-0001-5658-3522
канд. мед. наук, врач-кардиолог
俄罗斯联邦, MoscowTatiana Soboleva
Sechenov First Moscow State Medical University (Sechenov University)
Email: soboleva_galina@inbox.ru
ORCID iD: 0000-0003-4509-1068
студентка лечебного фак-та
俄罗斯联邦, MoscowMerab Shariya
Chazov National Medical Research Center of Cardiology; Sechenov First Moscow State Medical University (Sechenov University)
Email: soboleva_galina@inbox.ru
ORCID iD: 0000-0002-0370-5204
д-р мед. наук, вед. науч. сотр. отд. томографии Научно-исследовательского института клинической кардиологии им. А.Л. Мясникова, проф. каф. лучевой диагностики ФГБУ «НМИЦ кардиологии им. акад. Е.И. Чазова»
俄罗斯联邦, Moscow; MoscowSergey Ternovoy
Chazov National Medical Research Center of Cardiology; Sechenov First Moscow State Medical University (Sechenov University)
Email: soboleva_galina@inbox.ru
ORCID iD: 0000-0003-4374-1063
акад. РАН, д-р мед. наук, проф., гл. науч. сотр. отд. томографии Научно-исследовательского института клинической кардиологии им. А.Л. Мясникова, зав. каф. лучевой диагностики (Сеченовский Университет)
俄罗斯联邦, Moscow; MoscowYuri Karpov
Chazov National Medical Research Center of Cardiology
Email: soboleva_galina@inbox.ru
ORCID iD: 0000-0003-1480-0458
д-р мед. наук, проф., гл. науч. сотр. отд. ангиологии Научно-исследовательского института клинической кардиологии им. А.Л. Мясникова
俄罗斯联邦, Moscow参考
- Барбараш О.Л., Карпов Ю.А., Кашталап В.В., и др. Стабильная ишемическая болезнь сердца. Клинические рекомендации 2020. Российское кардиологическое общество. Российский кардиологический журнал. 2020;25(11):201-50 [Barbarash OL, Karpov YA, Kashtalap VV, et al. 2020 Clinical practice guidelines for stable coronary artery disease. Russian Journal of Cardiology. 2020;25(11):201-50 (in Russian)]. doi: 10.15829/1560-4071-2020-4076
- Knuuti J,Wijns W, Saraste A, et al. 2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes. Eur Heart J. 2020;41(3):407-77. doi: 10.1093/eurheartj/ehz425
- Seitun S, De Lorenzi C, Cademartiri F, et al. CT Myocardial perfusion imaging: a new frontier in cardiac imaging. Biomed Res Int. 2018;2018:1-21. doi: 10.1155/2018/7295460
- Takx RAP, Сeleng C, Schoepf UJ, et al. CT myocardial perfusion imaging: ready for prime time? Eur J Radiol. 2018;28(3):1253-6. doi: 10.1007/s00330-017-5057-8
- Hasbek Z, Ertürk SA, Çakmakçılar A, et al. Evaluation of myocardial perfusion imaging SPECT parameters and pharmacologic stress test with adenosine versus coronary angiography findings: are they diagnostically concordant? Mol Imaging Radionucl Ther. 2019;28(2):53-61. doi: 10.4274/mirt.galenos.2019.47450
- Mor-Avi V, Kachenoura N, Maffessanti F, et al. Three-dimensional quantification of myocardial perfusion during regadenoson stress computed tomography. Eur J Radiol. 2016;85(5):885-92. doi: 10.1016/j.ejrad.2016.02.028
- Минасян А.А., Соболева Г.Н., Гаман С.А., и др. Безопасность и эффективность объемной компьютерной томографии сердца в сочетании с фармакологической пробой с аденозинтрифосфатом в диагностике ишемической болезни сердца. Кардиология. 2020;60(11):57-65 [Minasyan AA, Soboleva GN, Gaman SA, et al. Safety and Effectiveness of Volumetric Computed Tomography of the Heart in Combination with a PharmacologicaTest with Adenosine Triphosphate in the Diagnosis of Coronary Heart Disease. Kardiologiia. 2020;60(11):57-65 (in Russian)]. doi: 10.18087/cardio.2020.11.n1258
- Алгоритмы специализированной медицинской помощи больным сахарным диабетом. 10-й вып. Под ред. И.И. Дедова, М.В. Шестаковой, А.Ю. Майорова. М., 2021 [Algoritmy spetsializirovannoi meditsinskoi pomoshchi bol'nym sakharnym diabetom. 10-i vyp. Pod red. II Dedova, MV Shestakovoy, AIu Maiorova. Moscow, 2021 (in Russian)].
- Cosentino F, Grant PJ, Aboyans V, et al. 2019 Рекомендации ЕSC/EASD по сахарному диабету, предиабету и сердечно-сосудистым заболеваниям. Российский кардиологический журнал. 2020;25(4):3839 [Cosentino F, Grant PJ, Aboyans V, et al. Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds/Leeds Teaching Hospitals NHS Trust, LIGHT Laboratories, Clarendon Way. Russian Journal of Cardiology. 2020;25(4):3839 (in Russian)]. doi: 10.15829/1560-4071-2020-3839
- Shah AD, Langenberg C, Rapsomaniki E, et al. Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1.9 million people. Lancet Diabetes Endocrinol. 2015;3:105-13. doi: 10.1016/S2213-8587(14)70219-0
- D'Andrea A, Nistri S, Castaldo F, et al. The relationship between early left ventricular myocardial alterations and reduced coronary flow reserve in non-insulin-dependent diabetic patients with microvascular angina. Int J Cardiol. 2012;154(3):250-5. doi: 10.1016/j.ijcard.2010.09.044
- Sharma A, Coles A, Sekaran NK, et al. Stress testing versus CT angiography in patients with diabetes and suspected coronary artery disease. J Am Coll Cardiol. 2019;73(8):893-902. doi: 10.1016/j.jacc.2018.11.056
- Минасян А.А., Гаман С.А., Соболева Г.Н., и др. Показатели объемной компьютерной томографии сердца с фармакологической пробой с натрия аденозинтрифосфатом в диагностике стабильной ишемической болезни сердца. Кардиологический вестник. 2021;16(2):53-8 [Minasyan AA, Gaman SA, Soboleva GN, et al. Parameters of volume computed tomography combined with adenosine triphosphate test in diagnosis of stable coronary artery disease. Russian Cardiology Bulletin. 2021;16(2):53-8. (in Russian)]. doi: 10.17116/Cardiobulletin20211602153
- Дедов И.И., Александров А.А. Сахарный диабет и коронарный резерв миокарда: перспективы статинов. РМЖ. 2005;28(252):1944 [Dedov II, Alexandrov AA. Diabetes Mellitus and Myocardial Coronary Reserve: Statins Perspectives. RMJ. 2005;28(252):1944 (in Russian)].