Thrombosis in patients with myeloproliferative neoplasms. Case report
- Authors: Melikyan A.L.1, Subortseva I.N.1, Gilyazitdinova E.A.1, Koloshejnova T.I.1, Shashkina K.S.1, Egorova E.K.1, Kovrigina A.M.1, Sudarikov A.B.1, Gorgidze L.A.1
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Affiliations:
- National Research Center for Hematology
- Issue: Vol 93, No 7 (2021)
- Pages: 800-804
- Section: Clinical notes
- URL: https://journals.rcsi.science/0040-3660/article/view/76322
- DOI: https://doi.org/10.26442/00403660.2021.07.200925
- ID: 76322
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Abstract
Thrombotic complications are the most significant factors determining the prognosis in myeloproliferative neoplasms. Markers for assessing the risk of thrombosis are the number of leukocytes, platelets, hemoglobin level, hematocrit, age, molecular status, history of thrombosis, obesity, arterial hypertension, hyperlipidemia, hereditary or acquired thrombophilia. The pathogenesis of thrombosis in patients with myeloproliferative neoplasms is complex and multifactorial. In most cases, the etiological factor remains unknown. Currently, antiplatelet and anticoagulant therapy is carried out on an individual basis. The algorithm for primary and secondary (after thrombosis) prevention requires development and testing. We present a clinical case of repeated arterial and venous thrombotic complications in a patient with primary myelofibrosis.
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##article.viewOnOriginalSite##About the authors
Anait L. Melikyan
National Research Center for Hematology
Author for correspondence.
Email: anoblood@mail.ru
ORCID iD: 0000-0002-2119-3775
д-р мед. наук, зав. научно-клиническим отд-нием стандартизации методов лечения, врач-гематолог
Russian Federation, MoscowIrina N. Subortseva
National Research Center for Hematology
Email: anoblood@mail.ru
ORCID iD: 0000-0001-9045-8653
канд. мед. наук, cт. науч. сотр., врач-онколог научно-клинического отд-ния стандартизации методов лечения
Russian Federation, MoscowElena A. Gilyazitdinova
National Research Center for Hematology
Email: anoblood@mail.ru
ORCID iD: 0000-0002-3883-185X
врач-гематолог научно-клинического отд-ния стандартизации методов лечения
Russian Federation, MoscowTamara I. Koloshejnova
National Research Center for Hematology
Email: anoblood@mail.ru
ORCID iD: 0000-0003-4580-040X
канд. мед. наук, зам. зав. научно-клиническим отд-нием стандартизации методов лечения
Russian Federation, MoscowKristina S. Shashkina
National Research Center for Hematology
Email: anoblood@mail.ru
ORCID iD: 0000-0003-1974-4870
врач-гематолог научно-клинического отд-ния стандартизации методов лечения
Russian Federation, MoscowElena K. Egorova
National Research Center for Hematology
Email: anoblood@mail.ru
ORCID iD: 0000-0001-6038-9474
канд. мед. наук, врач-гематолог научно-клинического отд-ния стандартизации методов лечения, зав. отд. внутреннего контроля качества
Russian Federation, MoscowAlla M. Kovrigina
National Research Center for Hematology
Email: anoblood@mail.ru
ORCID iD: 0000-0002-1082-8659
д-р биол. наук, зав. патолого- анатомическим отд-нием
Russian Federation, MoscowAndrei B. Sudarikov
National Research Center for Hematology
Email: anoblood@mail.ru
ORCID iD: 0000-0001-9463-9187
д-р биол. наук, проф., зав. лаб. молекулярной гематологии
Russian Federation, MoscowLana A. Gorgidze
National Research Center for Hematology
Email: anoblood@mail.ru
ORCID iD: 0000-0001-5235-2356
канд. биол. наук, ст. науч. сотр. отд-ния реанимации и интенсивной терапии с экспресс-лаб
Russian Federation, MoscowReferences
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