Thrombosis in patients with myeloproliferative neoplasms. Case report

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Abstract

Thrombotic complications are the most significant factors determining the prognosis in myeloproliferative neoplasms. Markers for assessing the risk of thrombosis are the number of leukocytes, platelets, hemoglobin level, hematocrit, age, molecular status, history of thrombosis, obesity, arterial hypertension, hyperlipidemia, hereditary or acquired thrombophilia. The pathogenesis of thrombosis in patients with myeloproliferative neoplasms is complex and multifactorial. In most cases, the etiological factor remains unknown. Currently, antiplatelet and anticoagulant therapy is carried out on an individual basis. The algorithm for primary and secondary (after thrombosis) prevention requires development and testing. We present a clinical case of repeated arterial and venous thrombotic complications in a patient with primary myelofibrosis.

About the authors

Anait L. Melikyan

National Research Center for Hematology

Author for correspondence.
Email: anoblood@mail.ru
ORCID iD: 0000-0002-2119-3775

д-р мед. наук, зав. научно-клиническим отд-нием стандартизации методов лечения, врач-гематолог

Russian Federation, Moscow

Irina N. Subortseva

National Research Center for Hematology

Email: anoblood@mail.ru
ORCID iD: 0000-0001-9045-8653

канд. мед. наук, cт. науч. сотр., врач-онколог научно-клинического отд-ния стандартизации методов лечения

Russian Federation, Moscow

Elena A. Gilyazitdinova

National Research Center for Hematology

Email: anoblood@mail.ru
ORCID iD: 0000-0002-3883-185X

врач-гематолог научно-клинического отд-ния стандартизации методов лечения

Russian Federation, Moscow

Tamara I. Koloshejnova

National Research Center for Hematology

Email: anoblood@mail.ru
ORCID iD: 0000-0003-4580-040X

канд. мед. наук, зам. зав. научно-клиническим отд-нием стандартизации методов лечения

Russian Federation, Moscow

Kristina S. Shashkina

National Research Center for Hematology

Email: anoblood@mail.ru
ORCID iD: 0000-0003-1974-4870

врач-гематолог научно-клинического отд-ния стандартизации методов лечения

Russian Federation, Moscow

Elena K. Egorova

National Research Center for Hematology

Email: anoblood@mail.ru
ORCID iD: 0000-0001-6038-9474

канд. мед. наук, врач-гематолог научно-клинического отд-ния стандартизации методов лечения, зав. отд. внутреннего контроля качества

Russian Federation, Moscow

Alla M. Kovrigina

National Research Center for Hematology

Email: anoblood@mail.ru
ORCID iD: 0000-0002-1082-8659

д-р биол. наук, зав. патолого- анатомическим отд-нием

Russian Federation, Moscow

Andrei B. Sudarikov

National Research Center for Hematology

Email: anoblood@mail.ru
ORCID iD: 0000-0001-9463-9187

д-р биол. наук, проф., зав. лаб. молекулярной гематологии

Russian Federation, Moscow

Lana A. Gorgidze

National Research Center for Hematology

Email: anoblood@mail.ru
ORCID iD: 0000-0001-5235-2356

канд. биол. наук, ст. науч. сотр. отд-ния реанимации и интенсивной терапии с экспресс-лаб

Russian Federation, Moscow

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