Email this article Detection of kidney dysfunction potential biomarkers with hypertension in the persons of 25–45 years
- Authors: Kovalkova N.A.1, Khudyakova A.D.1, Kashtanova E.V.1, Polonskaya Y.V.1, Shcherbakova L.V.1, Ragino Y.I.1
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Affiliations:
- Research Institute of Internal and Preventive Medicine – branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
- Issue: Vol 92, No 12 (2020)
- Pages: 19-24
- Section: Articles
- URL: https://journals.rcsi.science/0040-3660/article/view/60248
- DOI: https://doi.org/10.26442/00403660.2020.12.200436
- ID: 60248
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Abstract
Aim. To assess the significance of symmetrical dimethylarginine (SDMA), uromodulin, retinol-binding protein 4 (RSB-4), transforming growth factor b1 (TGF-b1), plasminogen activator inhibitor 1 (PAI-1) as kidney dysfunction potential biomarkers persons with hypertension in persons 25–45 years old.
Materials and methods. The study included 147 people. Hypertension was recorded with blood pressure (BP)≥140/90 mm Hg, renal dysfunction – with GFRCKD-EPI<90 ml/min/1.73 cm2. Four groups were formed: 1 – individuals with hypertension and GFR<90 ml/min/1.73 cm2; 2 – with hypertension and GFR≥90 ml/min/1.73 cm2; 3 – with BP<140/90 mm Hg and GFR<90 ml/min/1.73 cm2; 4 – with BP<140/90 mm Hg and GFR≥90 ml/min/1.73 cm2. The groups were comparable by gender, age, and number of respondents. Creatinine, SDMA, uromodulin, RSB-4, TGF-b1, PAI-1 levels were examined in all individuals in the serum.
Results. The maximum values of SDMA were determined in the 1st and 3rd groups (1.30 and 1.36 μmol/l). In the 1st group, an association was found between SDMA and GFR (r=-0.324; p=0.048). In the 1st group, the minimum values of uromodulin were recorded, in the 4th group – the maximum values (164.86 and 188.90 ng/ml; at the same time р=0.921). The level of RSB-4 was the highest in the 1st group, the lowest – in the 4th group (88.64 and 80.05 µg/ml; p=0.011). The association of RSB-4 with SDMA in the 3rd group (r=0.400; p=0.017), the 4th group (r=0.403; p=0.018) was detected. The level of TGF-b1 was 1.5 times higher in the 1st group than in the 3rd (23.16 and 15.99 µg/ml; p=0.026), the association of TGF-b1 with GFR in the 1st group had the opposite direction (r=-0.452; p=0.005). The study of similar indicators of PAI-1 did not reveal its relationship with renal dysfunction in hypertension.
Conclusion. The results of the study made it possible to consider SDMA, RSB-4, TGF-b1 as potential biomarkers of renal dysfunction in hypertension in persons 25–45 years old.
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##article.viewOnOriginalSite##About the authors
N. A. Kovalkova
Research Institute of Internal and Preventive Medicine – branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Author for correspondence.
Email: terap2000@yandex.ru
ORCID iD: 0000-0001-5368-1899
к.м.н., ст. науч. сотр.
Russian Federation, NovosibirskA. D. Khudyakova
Research Institute of Internal and Preventive Medicine – branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Email: terap2000@yandex.ru
ORCID iD: 0000-0001-5397-0498
аспирант
Russian Federation, NovosibirskE. V. Kashtanova
Research Institute of Internal and Preventive Medicine – branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Email: terap2000@yandex.ru
ORCID iD: 0000-0003-2268-4186
д.б.н., ст. науч. сотр.
Russian Federation, NovosibirskYa. V. Polonskaya
Research Institute of Internal and Preventive Medicine – branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Email: terap2000@yandex.ru
ORCID iD: 0000-0002-3538-0280
д.б.н., ст. науч. сотр.
Russian Federation, NovosibirskL. V. Shcherbakova
Research Institute of Internal and Preventive Medicine – branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Email: terap2000@yandex.ru
ORCID iD: 0000-0001-9270-9188
ст. науч. сотр.
Russian Federation, NovosibirskYu. I. Ragino
Research Institute of Internal and Preventive Medicine – branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences
Email: terap2000@yandex.ru
ORCID iD: 0000-0002-4936-8362
чл.-кор. РАН, д.м.н., врио руководителя
Russian Federation, NovosibirskReferences
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