Diagnosis and antibiotic therapy of nosocomial pneumonia in adults: from recommendations to real practice. A review
- Authors: Rachina S.А.1, Fedina L.V.2,3, Sukhorukova M.V.4, Sychev I.N.2,3, Larin E.S.5, Alkhlavov A.A.1
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Affiliations:
- Sechenov First Moscow State Medical University (Sechenov University)
- Yudin City Clinical Hospital
- Russian Medical Academy of Continuous Professional Education
- Burdenko National Medical Research Center for Neurosurgery
- Hospital for War Veterans №3
- Issue: Vol 95, No 11 (2023)
- Pages: 996-1003
- Section: Reviews
- URL: https://journals.rcsi.science/0040-3660/article/view/232017
- DOI: https://doi.org/10.26442/00403660.2023.11.202467
- ID: 232017
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Abstract
Nosocomial pneumonia is a healthcare-associated infection with significant consequences for the patient and the healthcare system. The efficacy of treatment significantly depends on the timeliness and adequacy of the antibiotic therapy regimen. The growth of resistance of gram-negative pathogens of nosocomial pneumonia to antimicrobial agents increases the risk of prescribing inadequate empirical therapy, which worsens the results of patient treatment. Identification of risk factors for infection with multidrug-resistant microorganisms, careful local microbiological monitoring with detection of resistance mechanisms, implementation of antimicrobial therapy control strategy and use of rational combinations of antibacterial drugs are of great importance. In addition, the importance of using new drugs with activity against carbapenem-resistant strains, including ceftazidime/aviabactam, must be understood. This review outlines the current data on the etiology, features of diagnosis and antibacterial therapy of nosocomial pneumonia.
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##article.viewOnOriginalSite##About the authors
Svetlana А. Rachina
Sechenov First Moscow State Medical University (Sechenov University)
Email: Svetlana.Ratchina@antibiotic.ru
ORCID iD: 0000-0002-3329-7846
профессор РАН, доктор медицинских наук, зав. кафедры госпитальной терапии №2 Института клинической медицины имени Н.В. Склифосовского
Russian Federation, MoscowLudmila V. Fedina
Yudin City Clinical Hospital; Russian Medical Academy of Continuous Professional Education
Email: Svetlana.Ratchina@antibiotic.ru
ORCID iD: 0000-0002-6417-9535
врач – клинический фармаколог ГБУЗ «ГКБ имени С.С. Юдина», аспирант кафедры клинической фармакологии и терапии ФГБОУ ДПО РМАНПО
Russian Federation, Moscow; MoscowMarina V. Sukhorukova
Burdenko National Medical Research Center for Neurosurgery
Author for correspondence.
Email: Svetlana.Ratchina@antibiotic.ru
ORCID iD: 0000-0002-1168-2356
кандидат медицинских наук, врач-бактериолог ФГАУ «НМИЦ нейрохирургии имени академика Н.Н. Бурденко»
Russian Federation, MoscowIgor N. Sychev
Yudin City Clinical Hospital; Russian Medical Academy of Continuous Professional Education
Email: Svetlana.Ratchina@antibiotic.ru
ORCID iD: 0000-0002-2970-3442
кандидат медицинских наук, зав. отделением клинической фармакологии ГБУЗ «ГКБ имени С.С. Юдина», доцент кафедры клинической фармакологии и терапии ФГБОУ ДПО РМАНПО
Russian Federation, Moscow; MoscowEgor S. Larin
Hospital for War Veterans №3
Email: Svetlana.Ratchina@antibiotic.ru
ORCID iD: 0000-0002-7450-6317
зам. глав. врача по анестезиологии и реаниматологии
Russian Federation, MoscowAbdulbari A. Alkhlavov
Sechenov First Moscow State Medical University (Sechenov University)
Email: Svetlana.Ratchina@antibiotic.ru
ORCID iD: 0009-0001-3685-4775
ординатор кафедры госпитальной терапии №2 Института клинической медицины имени Н.В. Склифосовского
Russian Federation, МоскваReferences
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