Body composition in sarcopenia in middle-aged individuals
- Authors: Samoilova I.G.1, Matveeva M.V.1, Khoroshunova E.A.1, Kudlay D.A.2,3, Tolmachev I.V.1, Spirina L.V.1,4, Mosienko I.V.1, Yun V.E.1, Trifonova E.I.1, Zakharchuk P.I.1, Vachadze T.D.1, Shuliko L.M.1, Galiukova D.E.1, Mutalimi V.E.1
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Affiliations:
- Siberian State Medical University
- Sechenov First Moscow State Medical University (Sechenov University)
- National Research Center – Institute of Immunology
- Cancer Research Institute of Tomsk National Research Medical Center of the Russian Academy of Sciences (Tomsk NRMC)
- Issue: Vol 94, No 10 (2022)
- Pages: 1149-1154
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/109956
- DOI: https://doi.org/10.26442/00403660.2022.10.201878
- ID: 109956
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Abstract
Sarcopenia is characterized by a progressive loss of muscle mass, strength, and function, leading to poor outcomes and reduced quality of life. In middle age, the decrease in muscle mass begins to be progressive. Bioimpedancemetry allows diagnosing this condition before the onset of clinical symptoms.
The purpose of the study: to evaluate the parameters of body composition in the early diagnosis of sarcopenia in middle-aged people.
Materials and Methods: The participants were divided into two groups – the main one with sarcopenia – 146 people and the control group – 75 people. The complex of examinations included: neuropsychological testing (Hospital Anxiety and Depression Scale (HADS), quality of life questionnaire for patients with sarcopenia (SarQoL), short health assessment form (SF-36)), 4-meter walking speed test, dynamometry and bioimpedancemetry.
The results of neuropsychological examination did not differ in the main and control groups. Patients with sarcopenia showed a decrease in muscle strength according to dynamometry. The scores of the walking speed assessment test in the study group were significantly higher than in the control group. The main and control groups had excessive body weight. According to the results of bioimpedanceometry, the main group had increased fat mass, percentage of fat mass, visceral fat area, and fat mass index compared with the control group. Skeletal muscle mass was less in the main group, probable sarcopenia was confirmed by decreased appendicular mass, decreased protein and mineral content was also recorded. There was a more pronounced decrease in cell mass in the main group. In patients with sarcopenia the volume of intracellular and extracellular fluid was less than in the control group. Significant differences were considered at p<0.05.
Conclusions: the introduction of bioimpedancemetry and dynamometry into early screening for muscle mass reduction will allow timely start of therapeutic and preventive measures even in middle age, which will lead to a decrease in the progression of sarcopenia in the elderly, as well as improve the quality of life.
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##article.viewOnOriginalSite##About the authors
Iuliia G. Samoilova
Siberian State Medical University
Email: samoilova_y@inbox.ru
ORCID iD: 0000-0002-2667-4842
д-р мед. наук, зав. каф. детских болезней, проф. каф. факультетской терапии с курсом клинической фармакологии ФГБОУ ВО СибГМУ
Russian Federation, TomskMariia V. Matveeva
Siberian State Medical University
Email: matveeva.mariia@yandex.ru
ORCID iD: 0000-0001-9966-6686
д-р мед. наук, доц. каф. детских болезней, доц. каф. общей врачебной практики и поликлинической терапии ФГБОУ ВО СибГМУ
Russian Federation, TomskEkaterina A. Khoroshunova
Siberian State Medical University
Email: katya.xoroshunova.96@bk.ru
ORCID iD: 0000-0002-3596-6732
аспирант каф. организации здравоохранения ФГБОУ ВО СибГМУ
Russian Federation, TomskDmitrii A. Kudlay
Sechenov First Moscow State Medical University (Sechenov University); National Research Center – Institute of Immunology
Email: kudlay_d_a@staff.sechenov.ru
ORCID iD: 0000-0002-4212-3848
чл.-кор. РАН, д-р мед. наук, проф. каф. фармакологии Института фармации им. А.П. Нелюбина ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет), вед. науч. сотр. лаб. персонализированной медицины и молекулярной иммунологии №71 ФГБУ ГНЦ «Институт иммунологии»
Russian Federation, Moscow; MoscowIvan V. Tolmachev
Siberian State Medical University
Email: kaf.med.kiber@ssmu.ru
ORCID iD: 0000-0002-2888-5539
канд. мед. наук, доц. каф. медицинской и биологической кибернетики ФГБОУ ВО СибГМУ
Russian Federation, TomskLudmila V. Spirina
Siberian State Medical University; Cancer Research Institute of Tomsk National Research Medical Center of the Russian Academy of Sciences (Tomsk NRMC)
Email: kaf.biohimia@ssmu.ru
ORCID iD: 0000-0002-5269-736X
д-р мед. наук, зав. каф., проф. каф. биохимии и молекулярной биологии с курсом клинической лабораторной диагностики ФГБОУ ВО СибГМУ, вед. науч. сотр. отд-ния биохимии опухоли Научно-исследовательского института онкологии ФГБНУ «Томский НИМЦ»
Russian Federation, Tomsk; TomskIgor V. Mosienko
Siberian State Medical University
Email: bolone08@mail.ru
ORCID iD: 0000-0002-8104-4325
врач-эндокринолог ФГБОУ ВО СибГМУ
Russian Federation, TomskVera E. Yun
Siberian State Medical University
Email: verayun05@mail.com
ORCID iD: 0000-0002-9127-8619
ассистент каф. педиатрии с курсом эндокринологии ФГБОУ ВО СибГМУ
Russian Federation, TomskEkaterina I. Trifonova
Siberian State Medical University
Email: trif18kate@gmail.com
ORCID iD: 0000-0002-2825-5035
ординатор каф. педиатрии с курсом эндокринологии ФГБОУ ВО СибГМУ
Russian Federation, TomskPolina I. Zakharchuk
Siberian State Medical University
Email: polya@yandex.ru
ORCID iD: 0000-0002-9809-4716
студентка ФГБОУ ВО СибГМУ
Russian Federation, TomskTamara D. Vachadze
Siberian State Medical University
Email: vtooma@mail.ru
ORCID iD: 0000-0001-6384-1972
студентка ФГБОУ ВО СибГМУ
Russian Federation, TomskLiudmila M. Shuliko
Siberian State Medical University
Email: ludmila.shuliko15@gmail.com
ORCID iD: 0000-0001-5299-2097
студентка ФГБОУ ВО СибГМУ
Russian Federation, TomskDaria E. Galiukova
Siberian State Medical University
Email: darya.galyukova@yandex.ru
ORCID iD: 0000-0003-2660-469X
студентка ФГБОУ ВО СибГМУ
Russian Federation, TomskVenera E. Mutalimi
Siberian State Medical University
Author for correspondence.
Email: mutalimivenera@yandex.ru
ORCID iD: 0000-0003-2816-5547
врач-педиатр, ассистент каф. педиатрии с курсом эндокринологии ФГБОУ ВО СибГМУ
Russian Federation, TomskReferences
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