Pharmacotherapy of inflammatory bowel diseases: efficacy performance and safety management
- Authors: Bakulin I.G.1, Skalinskaya M.I.1, Maev I.V.2, Skazyvaeva E.V.1, Zhuravleva M.S.1, Gaikovaya L.B.1, Bakulina N.V.1, Ermakov A.I.1, Alekseenko E.S.1, Ivanova K.N.1, Solovev M.V.3
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Affiliations:
- Mechnikov North-Western State Medical University
- Yevdokimov Moscow State University of Medicine and Dentistry
- Kirov Military Medical Academy
- Issue: Vol 93, No 8 (2021)
- Pages: 841-852
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/79366
- DOI: https://doi.org/10.26442/00403660.2021.08.200982
- ID: 79366
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Abstract
Treatment of inflammatory bowel diseases – IBD (Crohn’s disease, ulcerative colitis) is aimed at achieving clinical, endoscopic and histological remission, minimizing surgical complications, and ensuring a normal quality of life. However, the use of medical treatment is potentially associated with various adverse events, among which infectious complications, malignant neoplasms, as well as myelotoxicity, hepatotoxicity, skin lesions and others. The risk of side effects depends on the type of drug therapy (5-aminosalicylates, thiopurines, biologicals, etc.), the duration of treatment, the presence of extra-intestinal manifestations, etc. The article provides an overview of data on both the effectiveness and frequency of various side effects of the main classes of drugs in IBD, presents methods of investigation which can predict the effectiveness and development of side effects, the implementation of which can be considered as a variant of personalized therapy in IBD.
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##article.viewOnOriginalSite##About the authors
Igor G. Bakulin
Mechnikov North-Western State Medical University
Email: mskalinskaya@yahoo.com
ORCID iD: 0000-0002-6151-2021
доктор медицинских наук, профессор, заведующий кафедрой пропедевтики внутренних болезней, гастроэнтерологии и диетологии
Russian Federation, Saint PetersburgMaria I. Skalinskaya
Mechnikov North-Western State Medical University
Author for correspondence.
Email: mskalinskaya@yahoo.com
ORCID iD: 0000-0003-0769-8176
кандидат медицинских наук, доцент кафедры пропедевтики внутренних болезней и гастроэнтерологии
Russian Federation, Saint PetersburgIgor V. Maev
Yevdokimov Moscow State University of Medicine and Dentistry
Email: mskalinskaya@yahoo.com
ORCID iD: 0000-0001-6114-564X
академик РАН, доктор медицинских наук, профессор, заведующий кафедрой пропедевтики внутренних болезней и гастроэнтерологии
Russian Federation, MoscowEkaterina V. Skazyvaeva
Mechnikov North-Western State Medical University
Email: mskalinskaya@yahoo.com
ORCID iD: 0000-0002-8563-6870
кандидат медицинских наук, доцент кафедры пропедевтики внутренних болезней и гастроэнтерологии
Russian Federation, Saint PetersburgMariia S. Zhuravleva
Mechnikov North-Western State Medical University
Email: mskalinskaya@yahoo.com
ORCID iD: 0000-0003-4838-5707
кандидат медицинских наук, доцент кафедры пропедевтики внутренних болезней и гастроэнтерологии
Russian Federation, Saint PetersburgLarisa B. Gaikovaya
Mechnikov North-Western State Medical University
Email: mskalinskaya@yahoo.com
ORCID iD: 0000-0003-1000-1114
доктор медицинских наук, доцент, заведующий кафедрой биологической и общей химии
Russian Federation, Saint PetersburgNatalia V. Bakulina
Mechnikov North-Western State Medical University
Email: mskalinskaya@yahoo.com
ORCID iD: 0000-0003-4075-4096
доктор медицинских наук, профессор, заведующий кафедрой внутренних болезней, клинической фармакологии и нефрологии
Russian Federation, Saint PetersburgAleksei I. Ermakov
Mechnikov North-Western State Medical University
Email: mskalinskaya@yahoo.com
ORCID iD: 0000-0003-3435-5881
врач клинической лабораторной диагностики центральной клинико-диагностической лаборатории
Russian Federation, Saint PetersburgEkaterina S. Alekseenko
Mechnikov North-Western State Medical University
Email: mskalinskaya@yahoo.com
ORCID iD: 0000-0001-8250-4197
врач-ординатор кафедры пропедевтики внутренних болезней, гастроэнтерологии и диетологии
Russian Federation, Saint PetersburgKristina N. Ivanova
Mechnikov North-Western State Medical University
Email: mskalinskaya@yahoo.com
врач-ординатор каф. пропедевтики внутренних болезней, гастроэнтерологии и диетологии
Russian Federation, Saint PetersburgMikhail V. Solovev
Kirov Military Medical Academy
Email: mskalinskaya@yahoo.com
ORCID iD: 0000-0001-6832-0498
кандидат медицинских наук, доцент, врач-гастроэнтеролог, старший преподаватель кафедры госпитальной терапии
Russian Federation, Saint PetersburgReferences
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