Treatment of thrombotic thrombocytopenic purpura

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Abstract

The review discusses approaches to treatment of congenital thrombotic thrombocytopenic purpura (TTP) or Upshaw-Schulman syndrome. In congenital TTP, plasma transfusions are sufficient. Such treatment options as plasma exchange, administration of clotting factor VIII concentrate, recombinant ADAMTS13, are also used. Separately discussed issues of management of patients with TTP during pregnancy, and pediatric patients with TTP.

About the authors

Gennadii M. Galstyan

National Research Center for Hematology

Author for correspondence.
Email: e-gengalst@gmail.com
ORCID iD: 0000-0001-8818-8949

д-р мед. наук, зав. отд-нием реанимации и интенсивной терапии

Russian Federation, Moscow

Alexei A. Maschan

Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology

Email: e-gengalst@gmail.com
ORCID iD: 0000-0002-0016-6698

чл.-кор. РАН, д-р мед. наук, проф., зам. ген. дир. – дир. Института гематологии, иммунологии и клеточных технологий

Russian Federation, Moscow

Elizaveta E. Klebanova

National Research Center for Hematology

Email: e-gengalst@gmail.com
ORCID iD: 0000-0002-8141-9422

врач анестезиолог-реаниматолог отд-ния реанимации и интенсивной терапии

Russian Federation, Moscow

Irina I. Kalinina

Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology

Email: e-gengalst@gmail.com
ORCID iD: 0000-0002-0813-5626

канд. мед. наук, врач-гематолог отд-ния детской гематологии/онкологии

Russian Federation, Moscow

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