Extraesophageal signs of gastroesophageal reflux disease: otorhinolaryngologist’s view

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Abstract

The data on association between various pathologies of the ENT organs and gastroesophageal reflux disease (GERD) is analysed in the article. The variety of extraesophageal signs of GERD in children and adults is given, what is advisable to inform physicians of different specialties about the possibilities of antireflux therapy. These options are expanded with the emergence of a unique new drug, Alfasoxx. Its bioadhesive formula is based on hyaluronic acid and chondroitin sulphate thereby protecting the esophageal mucosa. Alfasoxx acts on the surface of the esophageal mucosa without penetrating into the systemic bloodstream and it also has a low allergenic potential, which has been confirmed by numerous studies. With its healing and repairing effect on erosive lesions of the esophageal epithelium, Alfasoxx in combination with proton pump inhibitors is more effective in achieving regression of clinical manifestations of the disease and improving patients’ quality of life (according to SF-36 questionnaire) compared to proton pump inhibitors monotherapy.

About the authors

Elena Yu. Radtsig

Pirogov Russian National Research Medical University

Author for correspondence.
Email: Radtsig_e@rsmu.ru
ORCID iD: 0000-0003-4613-922X

д.м.н., проф., проф. каф. оториноларингологии педиатрического фак-та

Russian Federation, Moscow

Daniil I. Konstantinov

Pirogov Russian National Research Medical University

Email: Radtsig_e@rsmu.ru
ORCID iD: 0000-0001-7514-4090

клинический ординатор каф. оториноларингологии педиатрического фак-та

Russian Federation, Moscow

References

  1. Mosca F, Rossillo V, Leone CA. Manifestations of gastro-pharyngo-laryngeal reflux disease. Acta Otorhinolaryngol Ital. 2006;26(5):247-51
  2. Федеральные клинические рекомендации по диагностике и лечению гастроэзофагеальной рефлюксной болезни у детей. Союз педиатров России. 2015 г. [Federal clinical guidelines for the diagnosis and treatment of gastroesophageal reflux disease in children. Union of Pediatricians of Russia. 2015 (In Russ.)].
  3. Рекомендации Российской гастроэнтерологической ассоциации по диагностике и лечению гастроэзофагеальной рефлюксной болезни. 2020 г. [Recommendations of the Russian Gastroenterological Association for the diagnosis and treatment of gastroesophageal reflux disease. 2020 (In Russ.)].
  4. Sataloff RT, Castell DO, Katz PO, Sataloff DM. Reflux-laryngitis and related disorders. 3rd edition. Plural Publishing, Inc, San Diego, Oxford, 2006.
  5. Massawe WA, Nkya A, Abraham ZS, et al. Laryngopharyngeal reflux disease, prevalence and clinical characteristics in ENT department of a tertiary hospital Tanzania. World J Otorhinolaryngol Head Neck Surg. 2020;7(1):28-33. doi: 10.1016/j.wjorl.2020.04.009. PMID: 33474541; PMCID: PMC7801257
  6. Han H, Lyu Q, Zhao J. Laryngopharyngeal Reflux in Hypertrophic Laryngeal Diseases. Ear Nose Throat J. 2020; p. 145561320953232. doi: 10.1177/0145561320953232
  7. Reiter R, Heyduck A, Seufferlein T, et al. Laryngopharyngealer Reflux [Laryngopharyngeal Reflux]. Laryngorhinootologie. 2018;97(4):238-45. doi: 10.1055/s-0044-100794
  8. Włodarczyk E, Jetka T, Raj-Koziak D, et al. Diagnosis of laryngopharyngeal reflux in children with voice disorders using 24-hour pharyngeal pH monitoring. Int J Pediatr Otorhinolaryngol. 2019;121:188-96. doi: 10.1016/j.ijporl.2019.03.010
  9. Saniasiaya J, Kulasegarah J. Dysphonia and reflux in children: A systematic review. Int J Pediatr Otorhinolaryngol. 2020;139:110473. doi: 10.1016/j.ijporl.2020.110473
  10. Saniasiaya J, Kulasegarah J. Dysphonia and reflux in children: A systematic review. Int J Pediatr Otorhinolaryngol. 2020;139:110473. doi: 10.1016/j.ijporl.2020.110473
  11. Wertz A, Carroll LM, Zur KB. Pediatric laryngopharyngeal reflux: Perceptual, acoustic, and laryngeal findings. Int J Pediatr Otorhinolaryngol. 2020;133:109974. doi: 10.1016/j.ijporl.2020.109974
  12. De Bortoli N, Nacci A, Savarino E, et al. How many cases of laryngopharyngeal reflux suspected by laryngoscopy are gastroesophageal reflux disease-related? World J Gastroenterol. 2012;18(32):4363-70. doi: 10.3748/wjg.v18.i32.4363
  13. Abou-Ismail A, Vaezi MF. Evaluation of patients with suspected laryngopharyngeal reflux: a practical approach. Curr Gastroenterol Rep. 2011;13(3):213-8. doi: 10.1007/s11894-011-0184-x
  14. Drug VL, Cobzeanu D, Papaghiuc C, et al. Implicarea bolii de reflux gastroesofagian in patologia orl [Gastroesophageal reflux involvement in ENT disorders]. Rev Med Chir Soc Med Nat Iasi. 2005;109(2):220-2. PMID: 16607774
  15. Wang JS, Li JR. The role of laryngopharyngeal reflux in the pathogenesis of Reinke’s edema. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016;30(24):1931-4. doi: 10.13201/j.issn.1001-1781.2016.24.007
  16. Wolford RW, Goyal A, Belgam Syed SY, Schaefer TJ. Pharyngitis. 2020 Nov 20. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2021. PMID: 3013783
  17. Zeng S, Chen J, Wei X, et al. Clinical observation of the anti-reflux treatment for the chronic pharyngitis patients with the reflux finding score from 8 to 10. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2020;34(5):441-3. doi: 10.13201/j.issn.2096-7993.2020.05.013
  18. Yazici ZM, Sayin I, Kayhan FT, Biskin S. Laryngopharyngeal reflux might play a role on chronic nonspecific pharyngitis. Eur Arch Otorhinolaryngol. 2010;267(4):571-4. doi: 10.1007/s00405-009-1044-2
  19. Hwang MS, Forman SN, Kanter JA, Friedman M. Tonsillar Helicobacter pylori colonization in chronic tonsillitis: systematic review and meta-analysis. JAMA Otolaryngol Head Neck Surg. 2015;141(3):245-9. doi: 10.1001/jamaoto.2014.3296
  20. Siupsinskiene N, Katutiene I, Jonikiene V, et al. Helicobacter pylori in the tonsillar tissue: a possible association with chronic tonsillitis and laryngopharyngeal reflux. J Laryngol Otol. 2017;131(6):549-56. doi: 10.1017/S0022215117000597
  21. Kaptan ZK, Emir H, Uzunkulaoğlu H, et al. Determination of Helicobacter pylori in patients with chronic nonspecific pharyngitis. Laryngoscope. 2009;119(8):1479-83. doi: 10.1002/lary.20253
  22. Fancy T, Mathers PH, Ramadan HH. Otitis media with effusion: a possible role for Helicobacter pylori? Otolaryngol Head Neck Surg. 2009;140(2):256-8. doi: 10.1016/j.otohns.2008.11.023
  23. Karlidag T, Bulut Y, Keles E, et al. Detection of Helicobacter pylori in children with otitis media with effusion: a preliminary report. Laryngoscope. 2005;115(7):1262-5. doi: 10.1097/01.MLG.0000165697.83921.2B
  24. Du P, Zong S, Wen Y, et al. Association between Helicobacter pylori and otitis media with effusion in children: A systematic review. Int J Pediatr Otorhinolaryngol. 2020;135:110091. doi: 10.1016/j.ijporl.2020.110091
  25. Wu X, Zheng Y, Gao X, et al. Association Between Helicobacter pylori Infection and Otitis Media With Effusion Risk in Children: A Systematic Review and Meta-analysis. Otolaryngol Head Neck Surg. 2020;163(4):654-61. doi: 10.1177/0194599820921861
  26. Boronat-Echeverría N, Aguirre-Mariscal H, Carmolinga-Ponce M, et al. Helicobacter pylori detection and clinical symptomatology of gastroesophageal reflux disease in pediatric patients with otitis media with effusion. Int J Pediatr Otorhinolaryngol. 2016;87:126-9. doi: 10.1016/j.ijporl.2016.06.023
  27. Khasawneh L, Khassawneh AH, Kheirallah KA, et al. Otitis media with effusion: The role of Helicobacter Pylori in its pathogenesis. Ann Med Surg (Lond). 2021;62:278-82. doi: 10.1016/j.amsu.2021.01.056
  28. O’Reilly RC, He Z, Bloedon E, et al. The role of extraesophageal reflux in otitis media in infants and children. Laryngoscope. 2008;118(Suppl. 116):1-9. doi: 10.1097/MLG.0b013e31817924a3
  29. O’Reilly RC, Soundar S, Tonb D, et al. The role of gastric pepsin in the inflammatory cascade of pediatric otitis media. JAMA Otolaryngol Head Neck Surg. 2015;141(4):350-7. doi: 10.1001/jamaoto.2014.3581
  30. Abtahi SH, Kazerooni A, Brejis N, et al. Prevalence and characteristics of gastroesophageal reflux in children with otitis media in Isfahan, Iran. Adv Biomed Res. 2016;5:81. doi: 10.4103/2277-9175.182212
  31. Boers SA, de Zeeuw M, Jansen R, et al. Characterization of the nasopharyngeal and middle ear microbiota in gastroesophageal reflux-prone versus gastroesophageal reflux non-prone children. Eur J Clin Microbiol Infect Dis. 2018;37(5):851-7. doi: 10.1007/s10096-017-3178-2
  32. Huang YD, Tan JJ, Han XY, et al. Study on the correlation between adenoid hypertrophy and laryngopharyngeal reflux in children. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2018;32(12):899-904. doi: 10.13201/j.issn.1001-1781.2018.12.005
  33. Niu X, Wu ZH, Xiao XY, Chen X. The relationship between adenoid hypertrophy and gastroesophageal reflux disease: A meta-analysis. Medicine (Baltimore). 2018;97(41):e12540. doi: 10.1097/MD.0000000000012540
  34. Keles B, Ozturk K, Arbag H, et al. Frequency of pharyngeal reflux in children with adenoid hyperplasia. Int J Pediatr Otorhinolaryngol. 2005;69(8):1103-7. doi: 10.1016/j.ijporl.2005.02.019
  35. Johnston J, Mahadevan M, Douglas RG. Incidence and factors associated with revision adenoidectomy: A retrospective study. Int J Pediatr Otorhinolaryngol. 2017;103:125-8. doi: 10.1016/j.ijporl.2017.10.023
  36. Brietzke SE, Shin JJ, Choi S, et al. Clinical consensus statement: pediatric chronic rhinosinusitis. Otolaryngol Head Neck Surg. 2014;151(4):542-53. doi: 10.1177/0194599814549302
  37. Rosen R, Vandenplas Y, Singendonk M, et al. Pediatric gastroesophageal reflux clinical practice guidelines. J Pediatr Gastroenterol Nutr. 2018;66(3):516-54. doi: 10.1097/MPG.0000000000001889
  38. Goldsmith AJ, Rosenfeld RM. Treatment of pediatric sinusitis. Pediatr Clin N Am. 2003;50(2):413-26. doi: 10.1016/s0031-3955(03)00027-0
  39. El-Serag HB, Gilger M, Kuebeler M, Rabeneck L. Extraesophageal associations of gastroesophageal reflux disease in children without neurologic defects. Gastroenterology. 2001;121(6):1294-9. doi: 10.1053/gast.2001.29545
  40. Dewan K, Lieu J. A Clinical Trial of Proton Pump Inhibitors to Treat Children with Chronic Otitis Media with Effusion. J Int Adv Otol. 2018;14(2):245-9. doi: 10.5152/iao.2018.4286
  41. Bothwell MR, Parsons DS, Talbot A, et al. Outcome of reflux therapy on pediatric chronic sinusitis. Otolaryngol Head Neck Surg. 1999;121(3):255-62. doi: 10.1016/S0194-5998(99)70181-6
  42. Savarino E, Zentilin P, Marabotto E, et al. Drugs for improving esophageal mucosa defense: where are we now and where are we going? Ann Gastroenterol. 2017;30(6):585-91. doi: 10.20524/aog.2017.0187
  43. Gaffney J, Matou-Nasri S, Grau-Olivares M, Slevin M. Therapeutic applications of hyaluronan. Mol Biosyst. 2010; 6(3):437-43. doi: 10.1039/b910552m
  44. Ialenti A, Di Rosa M. Hyaluronic acid modulates acute and chronic inflammation. Agents Actions. 1994; 43(1-2):44-7. doi: 10.1007/BF02005763
  45. Nolan A, Baillie C, Badminton J, et al. The efficacy of topical hyaluronic acid in the management of recurrent aphthous ulceration. J Oral Pathol Med. 2006;35:461-5. doi: 10.1111/j.1600-0714.2006.00433.x
  46. Kim Y, Kessler SP, Obery DR, et al. Hyaluronan 35kDa treatment protects mice from Citrobacter rodentium infection and induces epithelial tight junction protein ZO-1 in vivo. Matrix Biol. 2017;62:28-39. doi: 10.1016/j.matbio.2016.11.001
  47. Volpi N. Anti-inflammatory activity of chondroitin sulphate: new functions from an old natural macromolecule. Inflammopharmacology. 2011;19(6):299-306. doi: 10.1007/s10787-011-0098-0
  48. Du Souich P, Garcia AG, Verges J, Montell E. Immunomodulatory and anti-inflammatory effects of chondroitin sulphate. J Cell Mol Med. 2009;13:1451-63. doi: 10.1111/j.1582-4934.2009.00826.x
  49. Bonfils S, Dubrasquet M, Lambling A. The inhibition of peptic proteolysis by various polysaccharides. Rev Fr Etud Clin Biol. 1960;5:71-4
  50. Galzigna L, Previerocoletti MA. Action of sodium chondroitin sulfate on the enzymatic activity of pepsin. Gazz Med Ital. 1965;124:65-7
  51. Практические рекомендации всемирной гастроэнтерологической организации Дисфагия. Глобальные практические рекомендации и Каскады. Режим доступа: https://www.worldgastroenterology.org/UserFiles/file/guidelines/dysphagia-russian-2014.pdf. Ссылка активна на 29.03.2021 [Practical recommendations of the world gastroenterological organization Dysphagia. Global Best Practices and Cascades. Available at: https://www.worldgastroenterology.org/UserFiles/file/guidelines/dysphagia-russian-2014.pdf. Accessed: 29.03.2021 (In Russ.)].
  52. Lenzi G, Rapino P, Ferri S. On the behavior of gastric hydrochloric and peptic activity after administration of sodium chondroitin sulfate. Minerva Med. 1963;54:3421-4
  53. Ramya Devi D, Sandhya P, Vedha Hari BN. Poloxamer: a novel functional molecule for drug delivery and gene therapy. J Pharm Sci Res. 2013;5:159-65
  54. Dumortier G, Grossiord JL, Agnely F, Chaumeil JC. A review of poloxamer 407 pharmaceutical and pharmacological characteristics. Pharm Res. 2006; 23(12):2709-28. doi: 10.1007/s11095-006-9104-4
  55. Palmieri B, Corbascio D, Capone S, Lodi D. Preliminary clinical experience with a new natural compound in the treatment of esophagitis and gastritis: symptomatic effect. Trends Med. 2009;9:219-25
  56. Palmieri B, Merighi A, Corbascio D, et al. Fixed combination of hyaluronic acid and chondroitin-sulphate oral formulation in a randomized double blind, placebo controlled study for the treatment of symptoms in patients with non-erosive gastroesophageal reflux. Eur Rev Med Pharmacol Sci. 2013;17:3272-8
  57. Savarino V, Pace F, Scarpignato C, Esoxx Study Group Randomised clinical trial: mucosal protection combined with acid suppression in the treatment of non-erosive reflux disease – efficacy of Esoxx, a hyaluronic acid-chondroitin sulphate based bioadhesive formulation. Aliment Pharmacol Ther. 2017;45:631-42. doi: 10.1111/apt.13914

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2. Fig. 1. Dynamics of publications on the problem of GERD

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3. Fig. 2. Publications of otorhinolaryngologists on the problem of GERD

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