Molecular factors associated with regression of liver fibrosis of alcoholic etiology

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Abstract

Liver fibrosis develops as a result of chronic liver damage of various etiologies, is characterized by excessive synthesis of connective tissue by activated stellate liver cells. The toxic effect of alcohol is one of the most significant and common etiological factors worldwide. Stellate cell activation results from the interaction of multiple molecular fibrogenic pathways triggered by intracellular and extracellular, hepatic and extrahepatic stimuli. Data analysis showed that knowledge about these abnormal pathways and biomolecular processes may further contribute to the improvement of approaches to assessment of disease prognosis and treatment of alcoholic liver disease.

About the authors

Ya. V. Kiseleva

Sechenov First Moscow State Medical University (Sechenov University)

Email: dr_zharikov@mail.ru
ORCID iD: 0000-0002-0009-9245

студентка Международной школы «Медицина будущего» ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет)

Russian Federation, Moscow

Yu. O. Zharikov

Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: dr_zharikov@mail.ru
ORCID iD: 0000-0001-9636-3807

к.м.н., доц. каф. анатомии Института клинической медицины ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет)

Russian Federation, Moscow

R. V. Maslennikov

Sechenov First Moscow State Medical University (Sechenov University)

Email: dr_zharikov@mail.ru
ORCID iD: 0000-0001-7513-1636

к.м.н., ассистент каф. пропедевтики внутренних болезней Института клинической медицины ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет)

Russian Federation, Moscow

Ch. S. Pavlov

Sechenov First Moscow State Medical University (Sechenov University)

Email: dr_zharikov@mail.ru
ORCID iD: 0000-0001-5031-9798

д.м.н., проф., зав. каф. терапии Института профессионального образования, рук. Центра доказательной медицины ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет)

Russian Federation, Moscow

V. N. Nikolenko

Sechenov First Moscow State Medical University (Sechenov University); Lomonosov Moscow State University

Email: dr_zharikov@mail.ru
ORCID iD: 0000-0001-9532-9957

д.м.н., проф., зав. каф. анатомии человека Института клинической медицины ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» (Сеченовский Университет), зав. каф. нормальной и топографической анатомии ФГБОУ ВО «МГУ им. М.В. Ломоносова»

Russian Federation, Moscow; Moscow

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