Enteropathy with impaired membrane digestion and the prospects for cytoprotective therapy

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Abstract

The article describes enteropathy with impaired membrane digestion (EIMD) as a new nosological form. The main clinical manifestation of EIMD is the poor tolerance of food products, in particular carbohydrates and a decrease in the activity of membrane enzymes, in particular, carbohydrates, in the mucous membrane of the small intestine. The cause of the disease can be acute intestinal infections, viruses, drugs and other agents that damage the small intestine. The pathophysiology, clinical picture and diagnosis of EIMD are described. The basis of therapy is rebamipide, which has the ability to reduce the symptoms of carbohydrate intolerance and increase the activity of disaccharidases.

About the authors

A. I. Parfenov

Loginov Moscow Clinical Scientific Center

Author for correspondence.
Email: asfold@mail.ru
ORCID iD: 0000-0002-9782-4860

д.м.н., проф., зав. отд. патологии кишечника

Russian Federation, Moscow

O. V. Akhmadullina

Loginov Moscow Clinical Scientific Center

Email: asfold@mail.ru
ORCID iD: 0000-0001-7519-2041

к.м.н., мл. науч. сотр. отд-ния невоспалительной патологии кишечника

Russian Federation, Moscow

N. I. Belostotsky

Loginov Moscow Clinical Scientific Center

Email: asfold@mail.ru
ORCID iD: 0000-0003-4400-1227

д.м.н., ст. науч. сотр. лаб. доклинических методов исследования

Russian Federation, Moscow

E. A. Sabelnikova

Loginov Moscow Clinical Scientific Center

Email: asfold@mail.ru
ORCID iD: 0000-0001-7519-2041

д.м.н., ст. науч. сотр. отд-ния невоспалительной патологии кишечника, зам. дир. по научной работе

Russian Federation, Moscow

A. A. Novikov

Loginov Moscow Clinical Scientific Center

Email: asfold@mail.ru
ORCID iD: 0000-0002-2738-2956

д.б.н., вед. науч. сотр. лаб. клинической иммунологии

Russian Federation, Moscow

S. V. Bykova

Loginov Moscow Clinical Scientific Center

Email: asfold@mail.ru
ORCID iD: 0000-0001-9576-2953

к.м.н., зав. отд-нием невоспалительной патологии кишечника

Russian Federation, Moscow

S. R. Dbar

Loginov Moscow Clinical Scientific Center

Email: asfold@mail.ru
ORCID iD: 0000-0001-6516-7782

мл. науч. сотр. отд-ния невоспалительной патологии кишечника

Russian Federation, Moscow

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2. Fig. 1. Brush border of the enterocyte membrane [2]: a - TC villi (50 µm); b - enterocyte with a brush border (1 μm); c - brush border with microvilli; d - microvillus (0.2 μm).

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3. Fig. 2. The structure of amylose and amylopectin [7].

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4. Fig. 3. Algorithm for ENMP diagnostics.

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