Pharmacotherapy for acute respiratory infections caused by influenza viruses: current possibilities

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Abstract

Routinely the influenza virus significantly contributes to the formation of the annual incidence of acute respiratory infections, with a peak in winter season. The high level of mutagenic potential of influenza viruses is a standard factor determining the complexity of the rational choice of pharmacotherapy. The upcoming epidemiological season 2020–2021 brings additional challenges for health care practitioners mediated by the widespread prevalence in the human population of a new infection caused by the SARS-CoV-2 virus affecting the respiratory system among many organs and systems. An adequate choice of pharmacotherapy tools should be based on high efficiency and safety of drugs, with a possible reduction in such negative factors as polypharmacy. This review includes comparative pharmacological characteristics of drugs with activity against RNA viruses, along with parameters of their clinical efficacy.

About the authors

Sergey K. Zyryanov

People’s Friendship University of Russia; City Clinical Hospital №24

Email: butranova-oi@rudn.ru
ORCID iD: 0000-0002-6348-6867

д.м.н., проф., зав. каф. общей и клинической фармакологии ФГАОУ ВО РУДН, зам. глав. врача ГБУ ГКБ №24

Russian Federation, 6, Miklukho-Maklaya street, Moscow, 117198; Moscow

Olga I. Butranova

People’s Friendship University of Russia

Author for correspondence.
Email: butranova-oi@rudn.ru
ORCID iD: 0000-0001-7729-2169

к.м.н., доц. каф. общей и клинической фармакологии Медицинского института ФГАОУ ВО РУДН

Russian Federation, 6, Miklukho-Maklaya street, Moscow, 117198

Dmitry S. Gaidai

Saint Petersburg Institute of Pharmacy

Email: butranova-oi@rudn.ru
ORCID iD: 0000-0002-8773-5717

биолог отд. токсикологии и микробиологии, рук. исследований, ЗАО «Санкт-Петербургский институт фармации»

Russian Federation, Kuzmolovsky, 245, Leningrad. region, 188663

Kirill L. Kryshen

Saint Petersburg Institute of Pharmacy

Email: butranova-oi@rudn.ru
ORCID iD: 0000-0003-1451-7716

к.б.н., ст. науч. сотр. – рук. отд. токсикологии и микробиологии ЗАО «Санкт-Петербургский институт фармации»

Russian Federation, Kuzmolovsky, 245, Leningrad. region, 188663

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