The use of a new semi-quantitative rapid test for procalcitonin in the diagnosis of multisegmental community-acquired pneumonia

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Abstract

Aim. Evaluation of the possibilities of a new semi-quantitative rapid test for procalcitonin in the diagnosis of multisegmental community-acquired pneumonia.

Materials and methods. A one-stage comparative study involved 123 patients hospitalized in a hospital with a confirmed diagnosis of community-acquired pneumonia. The mean age of the patients was 49.5±21.0 (M±SD) years. On the first day of hospitalization, all patients underwent a general clinical examination, chest x-ray, and a plasma procalcitonin level was determined using a semi-quantitative rapid test.

Results. Indicators of a new semi-quantitative rapid test for procalcitonin of at least 2 ng/ml are directly related to laboratory and instrumental indicators reflecting the severity of community-acquired pneumonia, namely, the severity of respiratory failure (p=0.001), respiratory rate (p=0.001), and heart rate contractions (p=0.001), systolic blood pressure (p=0.025), oxygen saturation (p=0,001), erythrocyte sedimentation rate (p=0.021), fibrinogen (p=0.003) and high CRB-65 scores (p=0.001). They are also associated with multisegmental community-acquired pneumonia (÷2=4.7; p=0.030) and complications of this disease, such as hydrothorax (p=0.029) and death (÷2=22.1; p=0.001).

Conclusion. Using a new semi-quantitative rapid test for procalcitonin allows you to optimize the diagnosis of complications of community-acquired pneumonia and determine the high risk of multisegmental pneumonia.

About the authors

Sabina S. Bayramova

Institute of Internal and Preventive Medicine – a branch of The Federal Research Center Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences

Author for correspondence.
Email: sabina0412@mail.ru
ORCID iD: 0000-0002-4488-2493

мл. науч. сотр. лаб. неотложной терапии НИИТПМ – филиала ИЦиГ СО РАН

Russian Federation, 630089, Russia, Novosibirsk, st. B. Bogatkova, 175/1

Konstantin Yu. Nikolayev

Institute of Internal and Preventive Medicine – a branch of The Federal Research Center Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences

Email: nikolaevky@yandex.ru
ORCID iD: 0000-0003-4601-6203

д.м.н., проф., зав. лаб. неотложной терапии НИИТПМ – филиала ИЦиГ СО РАН

Russian Federation, 630089, Russia, Novosibirsk, st. B. Bogatkova, 175/1

Oksana V. Tsygankova

Institute of Internal and Preventive Medicine – a branch of The Federal Research Center Institute of Cytology and Genetics, the Siberian Branch of the Russian Academy of Sciences; Novosibirsk State Medical University

Email: oksana_c.nsk@mail.ru
ORCID iD: 0000-0003-0207-7063

д.м.н., проф. каф. неотложной терапии с эндокринологией и профпатологией ФГБОУ ВО НГМУ, ст. науч. сотр. лаб. клинических биохимических и гормональных исследований терапевтических заболеваний НИИТПМ – филиала ИЦиГ СО РАН

Russian Federation, 630091, Russia, Novosibirsk, st. Krasnyj prospeсt, 52; 630089, Russia, Novosibirsk, st. B. Bogatkova, 175/1

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