Possibility of complex medicamental and endovascular treatment of pulmonary hypertension in Takayasu arteritis with predominant pulmonary arteries’ lesion
- Authors: Маrtynuk T.V.1, Aleevskaya A.M.1, Gramovich V.V.1, Danilov N.M.1, Korobkova I.Z.1, Matchin U.G.1, Solodovnikova L.V.2, Beketova T.V.3
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Affiliations:
- National Medical Research Center for Cardiology
- Mordovia Republican Central Clinical Hospital
- Nasonova Research Institute of Rheumatology
- Issue: Vol 92, No 5 (2020)
- Pages: 85-91
- Section: Consensuns
- URL: https://journals.rcsi.science/0040-3660/article/view/34589
- DOI: https://doi.org/10.26442/00403660.2020.05.000623
- ID: 34589
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Abstract
Takayasu arteritis (TA) is a systemic vasculitis with predominatly lesions of aorta and its large branches. In some cases pulmonary arteries (PA) are involved in the pathological inflammatory process and lead to the formation of pulmonary hypertension and significantly worse the prognosis. Timely development of lesion of PA, appointment of adequate therapy and surgical treatment can prevent irreversible damage of blood vessels and improve the prognosis. Perioperative administration of interleukin-6 inhibitor inhibitor (tocilizumab) in at patients with indications for vascular surgery, including angioplasty PA, should be considered as a promising approach to control the inflammatory activity of TA, reduce the dose of glucocorticoids and the risk of postoperative complications. We present the clinical experience of significant improvement in the patient’s condition was achieved by using two-stage balloon angioplasty on the background of control of the disease activity with interleukin-6 tocilizumab intravenously and specific therapy with riociguat and iloprost.
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##article.viewOnOriginalSite##About the authors
T. V. Маrtynuk
National Medical Research Center for Cardiology
Author for correspondence.
Email: trukhiniv@mail.ru
д.м.н., рук. отд. легочной гипертензии и заболеваний сердца; проф. каф. кардиологии фак-та дополнительного профессионального образования
Russian Federation, MoscowA. M. Aleevskaya
National Medical Research Center for Cardiology
Email: trukhiniv@mail.ru
лаборант-исследователь отд. легочной гипертензии и заболеваний сердца
Russian Federation, MoscowV. V. Gramovich
National Medical Research Center for Cardiology
Email: trukhiniv@mail.ru
к.м.н., ст. науч. сотр. отд. легочной гипертензии и заболеваний сердца
Russian Federation, MoscowN. M. Danilov
National Medical Research Center for Cardiology
Email: trukhiniv@mail.ru
д.м.н., вед. науч. сотр. отд. гипертонии
Russian Federation, MoscowI. Z. Korobkova
National Medical Research Center for Cardiology
Email: trukhiniv@mail.ru
к.м.н., зав. кабинетом рентгенографии
Russian Federation, MoscowU. G. Matchin
National Medical Research Center for Cardiology
Email: trukhiniv@mail.ru
д.м.н., проф., рук. отд. рентгенэндоваскулярных методов диагностики и лечения в амбулаторных условиях
Russian Federation, MoscowL. V. Solodovnikova
Mordovia Republican Central Clinical Hospital
Email: trukhiniv@mail.ru
врач-ревматолог
Russian Federation, SaranskT. V. Beketova
Nasonova Research Institute of Rheumatology
Email: trukhiniv@mail.ru
д.м.н., проф., вед. науч. сотр. лаб. микроциркуляции и воспаления
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