Lipid status and oxidative stress in menopausal women with obstructive apnea syndrome


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Abstract

Aim: to assess lipid profile, lipid peroxidation and antioxidant system parameters in peri - and postmenopausal women with obstructive sleep apnea syndrome (OSAS). Materials and methods. 37 perimenopausal women and 43 postmenopausal ones were examined. OSAS diagnosis was made on the basis of the clinical picture and the polysomnography results. In perimenopause, the main group consisted of 18 women, in postmenopausal women - 17. All comparison groups are comparable by age and body mass index. Lipid profile, lipid peroxidation and antioxidant system parameters by spectrophotometric methods were determined. Non - parametric criteria were used to analyze the group differences for the independent samples. Results and discussion. The increase of total cholesterol (TC) and low - density lipoprotein cholesterol (LDL-C) levels were observed in perimenopausal women with OSAS as compared to control. The increase of TC, triacylglycerol (TG), LDL-C, very - low - density lipoprotein cholesterol (VLDL-C) levels and decrease of high - density lipoprotein cholesterol (HDL-D) level were found in postmenopausal women with OSAS as compared to control. Accumulation of ketodienes and conjugated trienes in perimenopausal women with OSAS and thiobarbituric acid reactants with a decrease of total antioxidant activity of blood serum in postmenopausal women with OSAS as compared to control was observed. Moreover, postmenopausal women with OSAS have a higher lipid peroxidation substrates and diene conjugates levels with a lower α-tocopherol level and total antioxidant activity compared with perimenopausal patients.The integral indicator of oxidative stress assessment indicates an imbalance in the lipid peroxidation and antioxidant system in menopausal women with OSAS. Conclusion. The results obtained indicate a violation of lipid metabolism and the development of oxidative stress in patients with OSAS. This is most pronounced in the postmenopause due to the aggravation of the pathological condition.

About the authors

L I Kolesnikova

Scientific Centre for Family Health and Human Reproduction Problems

д.м.н., проф., академик РАН, научный руководитель ФГБНУ «НЦ ПЗСРЧ»; ORCID: 0000-0003-3354-2992 Irkutsk Russia

N V Semenova

Scientific Centre for Family Health and Human Reproduction Problems

к.б.н., с.н.с. лаб. патофизиологии; ORCID: 0000-0002-6512-1335 Irkutsk Russia

E V Osipova

Scientific Centre for Family Health and Human Reproduction Problems

д.б.н., проф., в.н.с. лаб. патофизиологии; ORCID: 0000-0003-4611-6300 Irkutsk Russia

I M Madaeva

Scientific Centre for Family Health and Human Reproduction Problems

д.м.н., руководитель сомнологического центра; ORCID: 0000-0003-3423-7260 Irkutsk Russia

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