Relationship of the ovarian reserve with autoimmune thyroid diseases in the reproductive period


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Abstract

Aim. To compare ovarian reserve in healthy women of reproductive age - carriers of antithyroid antibodies (ATA) and in healthy women of reproductive age negative for ATA. Materials and methods. 70 healthy women of young reproductive age in the state of euthyroidism (from 18 to 38 years old) were examined. Participants were divided into equal groups (n=35) depending on the status of the presence of antithyroid antibodies (AT-TPO, AT-TG). On the 2nd-4th days of the menstrual cycle, the following markers of the ovarian reserve were determined: serum levels of anti-Müllerian hormone (AMG), inhibin B, FSH, LH, estradiol, testosterone and progesterone, as well as ultrasound parameters - the number of antral follicles and the volume of the ovaries. In addition, to determine the predisposition to premature ovarian failure, an analysis was performed to the number of CGG repeats in the FMR1 gene. Results and discussion. Statistically significantly differs such parameters as the level of estradiol and testosterone, while the differences were not clinically significant. All the parameters evaluated were within the normal range, the main predictors of the ovarian reserve (levels of AMG and inhibin B, the number of antral follicles) remained in the normal range. An increase in the number of repeats of CGG in the FMR1 gene was not detected in any of the participants in the study. Conclusion. In healthy young reproductive age women, the status of ATA does not have a direct effect on the ovarian reserve.

About the authors

O R Grigoryan

Endocrinology Research Centre

Email: iceberg1995@mail.ru
д.м.н., проф., гл.н.с. отд-ния эндокринной гинекологии ФГБУ «НМИЦ эндокринологии»; ORCID: 0000-0003-4979-7420; eLibrary SPIN: 3060-8242 Moscow, Russia

N S Krasnovskaya

City clinic №9

врач-эндокринолог ГБУЗ «ГП №9» ДЗМ г. Москвы; ORCID: 0000-0002-2683-9387 Moscow, Russia

R K Mikheev

Yevdokimov Moscow State University of Medicine and Dentistry

студент ФГБОУ ВО «МГМСУ им. А.И. Евдокимова»; ORCID: 0000-0001-5826-3186 Moscow, Russia

I S Yarovaia

Endocrinology Research Centre

к.м.н., врач акушер-гинеколог ФГБУ «НМИЦ эндокринологии»; ORCID: 0000-0003-3222-5936 Moscow, Russia

E N Andreeva

Endocrinology Research Centre; Yevdokimov Moscow State University of Medicine and Dentistry

д.м.н., директор Института репродуктивной медицины; зав. отд-нием эндокринной гинекологии ФГБУ «НМИЦ эндокринологии»; проф. каф. репродуктивной медицины и хирургии ФГБОУ ВО «МГМСУ им. А.И. Евдокимова»; ORCID: 0000-0001-8425-0020; eLibrary SPIN: 1239-2937 Moscow, Russia

I I Dedov

Endocrinology Research Centre

д.м.н., проф., академик РАН, президент ФГБУ «НМИЦ эндокринологии»; ORCID: 0000-0002-8175-7886 Moscow, Russia

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