Epicardial adipose tissue as a marker of visceral obesity and its association with metabolic parameters and remodeling of the left chambers of the heart in young people with abdominal obesity


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Abstract

Aim: to study the correlation of epicardial adipose tissue (EAT) with metabolic parameters, 24-hours profile of blood pressure (BP) and left ventricular remodeling, with the volume of intraabdominal adipose tissue (IAAT), measured by multislice computed tomography (MSCT) in patients with abdominal obesity and metabolic syndrome. Materials and methods: the study included 80 participants with abdominal obesity (waist circumference > 80 cm in women and >94 cm in men) and without cardiovascular diseases and diabetes. Within this study the following examinations were performed: waist circumference and the body mass index measurement, blood sampling and measurements of lipid levels, uric acid, fasting glucose, insulin, HOMA index, 24-hour ambulatory blood pressure monitoring. Left ventricular (LV) mass index, relative wall thickness, LV mass/height index were estimated from echocardiographic data. EAT volume and IAAT was measured by MSCT. All patients was devided in two groups for analysis: 1 (n=28) - patients with isolated abdominal obesity, without metabolic syndrome, age was 37.5±6.43 years; 2 (n=52) - patients with metabolic syndrome, age - 38.8±5.88 years. The control group 0 included healthy individuals (n=13) without obesity, age was 30.5±5.97 years. Results. A positive correlation was found between the volume of EAT with the level of insulin in the blood (r=0.2937, p<0.05), HOMA-IR (r=0.3068, p<0.05), negative correlation - with high density lipoproteins cholesterol (HDL cholesterol; r=-0.2328, p<0.05). The EAT volume correlated with mean diastolic blood pressure at night (r=0.2270, p<0.05). Quantitative analysis by cardiac parameters showed that EAT volume had correlation with the size of the left atrium (r=0.3907, p<0.05), LV mass (r=0.4566, p<0.05), the left ventricular myocardium mass index (r=0.2700, p<0.05) and relative wall thickness(r=0.2991, p<0.05). The EAT volume correlated with the volume of IAAT (r=0.6330, p<0.05), negative correlation - with the ratio of the volume of subcutaneous fat to IAAT (r=-0.4236, p<0.05). Conclusion. In the presented study the EAT volume was associated with the insulin resistance index, metabolic parameters and remodeling parameters of the left heart in young people with abdominal obesity. EAT can be considered as a marker of visceral obesity because it strongly correlated with IAAT.

About the authors

N V Blinova

National Medical Research Center of Cardiology

Email: nat-cardio1@yandex.ru
к.м.н., н.с. отд. гипертонии ФГБУ «НМИЦ кардиологии» Минздрава России; ORCID: 0000-0001-5215-4894 Moscow, Russia

M O Azimova

National Medical Research Center of Cardiology

аспирант отд. гипертонии Института клинической кардиологии им. А.Л. Мясникова ФГБУ «НМИЦ кардиологии» Минздрава России; ORCID: 0000-0002-7186-7117 Moscow, Russia

Y V Zhernakova

National Medical Research Center of Cardiology

д.м.н., ученый секретарь Института клинической кардиологии им. А.Л. Мясникова ФГБУ «НМИЦ кардиологии» Минздрава России; ORCID: 0000-0001-7895-9068 Moscow, Russia

E A Zheleznova

National Medical Research Center of Cardiology

лаборант-исследователь лаб. мониторинга программ по снижению смертности от сердечно-сосудистых заболеваний ФГБУ «НМИЦ кардиологии» Минздрава России Moscow, Russia

E B Yarovaya

National Medical Research Center of Cardiology

д.м.н., проф. каф. теории вероятностей механико-математического фак-та МГУ им. М.В. Ломоносова; ORCID: 0000-0003-3067-3786 Moscow, Russia

A A Orlovskiy

National Medical Research Center of Cardiology

студент каф. теории вероятностей механико-математического фак-та МГУ им. М.В. Ломоносова; ORCID: 0000-0002-0794-4683 Moscow, Russia

M R Azimova

National Medical Research Center of Cardiology

ординатор отд. гипертонии Института клинической кардиологии им. А.Л. Мясникова ФГБУ «НМИЦ кардиологии» Минздрава России Moscow, Russia

S V Dobrovolskaya

National Medical Research Center of Cardiology

врач лучевой диагностики Института клинической кардиологии им. А.Л. Мясникова ФГБУ «НМИЦ кардиологии» Минздрава России Moscow, Russia

S K Ternovoy

National Medical Research Center of Cardiology; Sechenov First Moscow State Medical University (Sechenov University)

д.м.н., проф., акад. РАМН, зав. каф. лучевой диагностики и лучевой терапии ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Минздрава России; руководитель отд. томографии Института клинической кардиологии им. А.Л. Мясникова ФГБУ «НМИЦ кардиологии» Минздрава России; ORCID: 0000-0003-4374-1063 Moscow, Russia

I E Chazova

National Medical Research Center of Cardiology

д.м.н., проф., акад. РАН, директор Института клинической кардиологии им. А.Л. Мясникова ФГБУ «НМИЦ кардиологии» Минздрава России; ORCID: 0000-0002-9822-4357 Moscow, Russia

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