The use of Tofacitinib in the treatment of inflammatory bowel disease


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Abstract

Major advances in pharmacology of the 21st century include the development of a new class of drugs, which are low-molecular, chemically synthesized molecules (the so-called "small molecules"), the point of application of which is Janus kinase (Janus kinase, JAK) involved in intracellular cytokine signaling. The review examines the molecular aspects of the JAK-STAT signaling pathway, justifying the use of the JAK-kinase inhibitor (tofacitinib) in the treatment of inflammatory bowel disease.

About the authors

E L Nasonov

V.A. Nasonova Research Institute of Rheumatology; I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Email: nasonov@irramn.ru
д.м.н., академик РАН, научный руководитель ФГБНУ «НИИР им. В.А. Насоновой», проф. каф. ревматологии ИПО ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова» Moscow, Russia

D I Abdulganieva

Kazan State Medical University of the Ministry of Health of the Russian Federation

д.м.н., проф., зав. каф. госпитальной терапии лечебного факультета ФГБОУ ВО КГМУ Kazan, Russia

I F Fairushina

Kazan State Medical University of the Ministry of Health of the Russian Federation

аспирант каф. госпитальной терапии лечебного факультета ФГБОУ ВО КГМУ Kazan, Russia

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