Autoimmune liver disease (primary biliary cholangitis/autoimmune hepatitis-overlap) associated with sarcoidosis (clinical cases and literature review)


Cite item

Full Text

Abstract

Clinical features of overlap autoimmune hepatitis/primary biliary cholangitis and morphological-proved sarcoid lesions (lungs, lymph nodes, skin) were performed. Data of long-term clinical observation presented in comparison with the results of laboratory datas, instrumental and morphological studies of liver tissue, lungs, skin. The modern aspects of pathogenesis of association autoimmune and granulomatous diseases arediscussed on the example of clinical cases of combination of cholestatic variants of autoimmune hepatitis and generalized sarcoidosis.

About the authors

E S Burnevich

Department of internal, occupational diseases and rheumatology, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University); City Clinical Hospital №24 of the Department of Health of Moscow

к.м.н., доцент каф. внутренних, профессиональных болезней и ревматологии медико-профилактического фак-та ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова»; ORCID: 0000-0002-7251-4284 Moscow, Russia

E N Popova

Department of internal, occupational diseases and rheumatology, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

Email: ela12@yandex.ru
д.м.н., проф., каф. внутренних, профессиональных болезней и ревматологии медико-профилактического фак-та ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова»; ORCID: 0000-0001-5164-4621 Moscow, Russia

A B Ponomarev

Department of pathological anatomy, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

к.м.н., доцент, каф. патологической анатомии им. акад. А.И. Струкова ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова»; ORCID: 0000-0002-4242-5723 Moscow, Russia

T P Nekrasova

Department of pathological anatomy, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

к.м.н., доцент, каф. патологической анатомии им. акад. А.И. Струкова ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова»; ORCID: 0000-0001-6376-9392 Moscow, Russia

M V Lebedeva

Department of internal, occupational diseases and rheumatology, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

к.м.н., доцент, каф. внутренних, профессиональных болезней и ревматологии медико-профилактического фак-та ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова»; ORCID: 0000-0002-5923-1837 Moscow, Russia

A L Filatova

Department of internal, occupational diseases and rheumatology, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

к.м.н., ассистент, каф. внутренних, профессиональных болезней и ревматологии медико-профилактического фак-та ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова»; ORCID: 0000-0002-1530-3464 Moscow, Russia

E M Shchanitcyna

Department of internal, occupational diseases and rheumatology, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

аспирант, каф. внутренних, профессиональных болезней и ревматологии медико-профилактического фак-та ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова»; ORCID: 0000-0002-1865-1309 Moscow, Russia

L A Ponomareva

Department of internal, occupational diseases and rheumatology, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

студентка лечебного фак-та ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова»; ORCID: 0000-0002-3179-470X Moscow, Russia

V D Beketov

Department of internal, occupational diseases and rheumatology, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

к.м.н., ассистент, каф. внутренних, профессиональных болезней и ревматологии медико-профилактического фак-та ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова»; ORCID: 0000-0002-6377-0630 Moscow, Russia

I B Bondarenko

Department of internal, occupational diseases and rheumatology, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

к.м.н., ассистент, каф. внутренних, профессиональных болезней и ревматологии медико-профилактического фак-та ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова»; ORCID: 0000-0002-4111-1175 Moscow, Russia

E L Tanashchuk

Department of internal, occupational diseases and rheumatology, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

к.м.н., доцент, каф. внутренних, профессиональных болезней и ревматологии медико-профилактического фак-та ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова»; ORCID: 0000-0002-4762-1993 Moscow, Russia

E N Nikulkina

Department of internal, occupational diseases and rheumatology, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

к.м.н., ассистент, каф. внутренних, профессиональных болезней и ревматологии медико-профилактического фак-та ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова»; ORCID: 0000-0001-6084-8749 Moscow, Russia

S V Moiseev

Department of internal, occupational diseases and rheumatology, I.M. Sechenov First Moscow State Medical University of the Ministry of Health of the Russian Federation (Sechenov University)

д.м.н., проф., зав. каф. внутренних, профессиональных болезней и ревматологии медико-профилактического фак-та ФГАОУ ВО «Первый МГМУ им. И.М. Сеченова»; ORCID: 0000-0002-7232-4640 Moscow, Russia

References

  1. Waldenstrom J. Blutproteine und Nahrungseiweiss. Dtsch Ges Verdau Stoffwechselkr. 1950;15:113-9. https://doi.org/10.1016/s0168-8278(02)00408-7
  2. Mackay I, Taft L, Cowling D. Lupoid hepatitis. Lancet. 1956;271:1323-6. https://doi.org/10.1016/s0140-6736(56)91483-0
  3. Mieli-Vergani G, Vergani D, Czaja A, Manns M, Krawitt E, Vierling J, Lohse A, Montano-Loza A. Autoimmune hepatitis. Nat Rev Dis Primers. 2018;4:18017. https://doi.org/10.1038/nrdp.2018.17
  4. Ozaslan E, Efe C, Gokbulut Ozaslan N. The diagnosis of antimitochondrial antibody - negative primary biliary cholangitis. Clin Res Hepatol Gastroenterol. 2016;40(5):553-61. https://doi.org/10.1016/j.clinre.2016.06.001
  5. Александрова Е.А., Авдеев В.Г., Бурневич Э.З., Арион Е.А. Первичный склерозирующий холангит - современные представления о патогенезе, диагностике, лечении. Терапевтический архив. 2012;8:86-90.
  6. Dyson J, Beuers U, Jones D, Lohse A, Hudson M. Primary sclerosing cholangitis. Lancet. 2018;391(10139):2547-59. https://doi.org/10.1016/s0140-67 36(18)30300-3
  7. Czaja A, Carpenter H. Autoimmune Hepatitis Overlap Syndromes and Liver Pathology. Gastroenterol Clin North Am. 2017;46(2):345-64. https://doi.org/10.1016/j.gtc.2017.01.008
  8. Guo L, Zhou L, Zhang N, Deng B, Wang B. Extrahepatic Autoimmune Diseases in Patients with Autoimmune Liver Diseases: A Phenomenon Neglected by Gastroenterologists. Gastroenterol Res Pract. 2017;2017: 2376231. Published online 2017 Jan 16. doi: 10.1155/2017/2376231
  9. Surani S, Mendez Y, Anjum H, Varon J. Pulmonary complications of hepatic diseases. World J Gastroenterol. 2016;22(26):6008-15. https://doi.org/10.3748/wjg.v22.i26.6008
  10. Shoenfeld Y, Blank M, Abu-Shakra M, Amital H, Barzilai O, Berkun Y, Bizzaro N, Gilburd B, Zandman-Goddard G, Katz U, Krause I, Langevitz P, Mackay I, Orbach H, Ram M, Sherer Y, Toubi E, Gershwin M. The mosaic of autoimmunity: prediction, autoantibodies, and therapy in autoimmune diseases - 2008. Isr Med Assoc J. 2008;10(1):13-9.
  11. Pamfil C, Candrea E, Berki E, Popov H, Radu P, Rednic S. Primary biliary cirrhosis - autoimmune hepatitis overlap syndrome associated with dermatomyositis, autoimmune thyroiditis and antiphospholipid syndrome. J Gastrointestin Liver Dis. 2015;24(1):101-4. https://doi.org/10.15403/jgld.201 4.1121.cpa
  12. Aksoy E, Yilmaz B., Köklü S. Autoimmune hepatitis/primary biliary cirrhosis overlap syndrome developed in a patient with vitiligo and Hashimoto thyroiditis. Eur J Gastroenterol Hepatol. 2013;25(1):121-2. https://doi. org/10.10 97/meg.0b013e328359493e
  13. Hutchinson J. Anomalous diseases of skin ad fingers; case of livid papillary psoriasis? In: Churchill J, Churchill A, eds. Illustrations of Clinical Surgery. London, 1877:42-3.
  14. Bargagli E, Prasse A. Sarcoidosis: a review for the internist. Intern Emerg Med. 2018;13(3):325-31. https://doi.org/10.1007/s11739-017-1778-6
  15. Корнев Б.М. Внелегочные проявления саркоидоза. Клиническая медицина. 1996;74(8):62-3.
  16. Попова Е.Н., Стрижаков Л.А., Шоломова В.И., Пономарев А.Б., Моисеев С.В., Бровко М.Ю., Бондаренко И.Б., Пономарева Л.А., Фомин В.В. Клинические особенности поражения сердца при саркоидозе. Терапевтический архив. 2018;1:54-9. https://doi.org/10.17116/ter arkh201890154-59
  17. Darlington P, Gabrielsen A, Sörensson P, Tallstedt L, Padyukov L, Eklund A, Grunewald J. HLA-alleles associated with increased risk for extra - pulmonary involvement in sarcoidosis. Tissue Antigens. 2014;83(4):267-72. https://doi.org/ 10.1111/tan.12326
  18. Medica I, Kastrin A, Maver A, Peterlin B. Role of genetic polymorphisms in ACE and TNF-alpha gene in sarcoidosis: a meta - analysis. J Hum Genet. 2007;52(10):836-47. https://doi.org/10.1007/s10038-007-0185-7
  19. Oswald-Richter K, Sato H, Hajizadeh R, Shepherd B, Sidney J, Sette A, Newman L, Drake W. Mycobacterial ESAT-6 and katG are recognized by sarcoidosis CD4+ T cells when presented by the American sarcoidosis susceptibility allele, DRB1*1101. J Clin Immunol. 2010;30(1):157-66. https://doi.org/10.1007/s10875-009-9311-y
  20. Darlington P, Tallstedt L, Padyukov L, Kockum I, Cederlund K, Eklund A, Grunewald J. HLA-DRB1* alleles and symptoms associated with Heerfordt's syndrome in sarcoidosis. Eur Respir J. 2011;38(5):1151-7. https://doi: 10.1183/ 09031936.00025011
  21. Faurie P, Broussolle C, Zoulim F, Trepo C, Sève P. Sarcoidosis and hepatitis C: clinical description of 11 cases. Eur J Gastroenterol Hepatol. 2010;22(8):967-72. https://doi.org/10.1097/meg.0b013e32833834bc
  22. Gayet A, Plaisance P, Bergmann J, Mouly S. Development of sarcoidosis following completion of treatment for hepatitis C with pegylated interferon-{alpha}2a and ribavirin: a case report and literature review. Clin Med Res. 2010;8(3-4):163-7. https://doi.org/10.3121/cmr.2010.886
  23. Brjalin V, Salupere R, Tefanova V, Prikk K, Lapidus N, Jõeste E. Sarcoidosis and chronic hepatitis C: a case report. World J Gastroenterol. 2012;18(40):5816-20. https://doi.org/10.3748/wjg.v18.i40.5816
  24. Willoughby J. Crohn's disease and sarcoidosis in siblings: follow - up of a published report with a new case and brief review of the literature. Frontline Gastroenterol. 2017;8(1):74-7. https://doi.org/10.1136/flgastro-2015-100666
  25. Wagner J, Skinner N, Catto-Smith A, Cameron D, Michalski W, Visvanathan K, Kirkwood C. TLR4, IL10RA, and NOD2 mutation in paediatric Crohn's disease patients: an association with Mycobacterium avium subspecies paratuberculosis and TLR4 and IL10RA expression. Med Microbiol Immunol. 2013;202(4):267-76. https://doi.org/10.1007/s00430-013-0290-5
  26. Strober W, Asano N, Fuss I, Kitani A, Watanabe T. Cellular and molecular mechanisms underlying NOD2 risk - associated polymorphisms in Crohn's disease. Immunol Rev. 2014;260(1):249-60. https://doi.org/10.1111/imr.12193
  27. Kishor S, Turner M, Borg B, Kleiner D, Cowen E. Cutaneous sarcoidosis and primary biliary cirrhosis: A chance association or related diseases? J Am Acad Dermatol. 2008;58(2):326-35. https://doi.org/10.1016/j.jaad.2007.07.031
  28. Cerri S, du Bois R, Spagnolo P. Genetic commonality between inflammatory bowel disease and sarcoidosis: the beginning of the end or the end of the beginning? Eur Respir J. 2011;37(3):489-91.

Copyright (c) 2019 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
 
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies