Relationships of arterial hypertension and reduced renal function in a population 25-45 years


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Abstract

Aim. To study relationships of reduced renal function with hypertension and other cardiometabolic risk factors in persons aged 25-45 years. Materials and methods. A cross-sectional population study of one of the typical district of Novosibirsk (Russia) was performed during 2013-2016 years. The study included 468 men and 606 women aged 25-45 years. Blood pressure (BP), waist circumference (WC), blood lipids, glucose, creatinine were measured. Glomerular filtration rate (GFR) was calculated with the formula CKD-EPI. Hypertension was registered if blood pressure (BP) was ≥140/90 mm Hg, reduced kidney function - at GFR<90 ml/min/1.73 cm2. Results. Prevalence of hypertension among men was 28%, among women - 9%. The proportion of people with GFR<90 ml/min/1.73 cm2 among men was 9.8%, among women - 34%. Among all examined people GFRs <60 ml/min/1.73 cm2 was revealed in 0.3% only. The association of hypertension with reduced renal function was determined only in men. Based on results of multivariate linear regression analysis, a significant negative association of GFR with age was determined, there was no association of GFR with systolic BP (SBP) in either men or women. In men, inverse relationships of GFR with low-density lipoprotein cholesterol (LDL-С), triglycerides (TG), direct - with WC were determined. Significant inverse association of GFR with diastolic BP (DBP) was revealed only after exception of TG from the regression model. In women, GFR's inverse relationship with LDL-С and DBP was observed, and the direct - with WC. In stepwise analysis the validity of all associations was confirmed after exception of the association of GFR with WC in men. Conclusions. In a population of 25-45 years a reduced GFR was associated with increased DBP; levels of LDL-С, TG showed negative association with GFR; in men increased TG levels were more important in reducing GFR than elevated DBP.

About the authors

N A Kovalkova

Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM - Branch of IC&G SB RAS), laboratory of clinical biochemical and hormonal studies of therapeutic diseases

Email: terap2000@yandex.ru
к.м.н., с.н.с. лаб. клинических биохимических и гормональных исследований терапевтических заболеваний НИИТПМ - филиала ИЦиГ СО РАН; ORCID: 0000-0001-5368-1899 Novosibirsk, Russia

Yu I Ragino

Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM - Branch of IC&G SB RAS), laboratory of clinical biochemical and hormonal studies of therapeutic diseases

Email: ragino@mail.ru
член-корр. РАН, д.м.н., зав. лаб. клинических биохимических и гормональных исследований терапевтических заболеваний НИИТПМ - филиала ИЦиГ СО РАН Novosibirsk, Russia

L V Scherbakova

Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM - Branch of IC&G SB RAS), laboratory of clinical biochemical and hormonal studies of therapeutic diseases

Email: 9584792@mail.ru
с.н.с. лаб. клинико-популяционных и профилактических исследований терапевтических и эндокринных заболеваний НИИТПМ - филиала ИЦиГ СО РАН Novosibirsk, Russia

A D Hudyakova

Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM - Branch of IC&G SB RAS), laboratory of clinical biochemical and hormonal studies of therapeutic diseases

Email: alene.elene@gmail.com
ординатор лаб. клинических биохимических и гормональных исследований терапевтических заболеваний НИИТПМ - филиала ИЦиГ СО РАН Novosibirsk, Russia

D V Denisova

Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM - Branch of IC&G SB RAS), laboratory of clinical biochemical and hormonal studies of therapeutic diseases

Email: denisovadiana@gmail.com
д.м.н., в.н.с. лаб. профилактической медицины НИИТПМ - филиала ИЦиГ СО РАН Novosibirsk, Russia

M I Voevoda

Research Institute of Internal and Preventive Medicine - Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences (IIPM - Branch of IC&G SB RAS), laboratory of clinical biochemical and hormonal studies of therapeutic diseases

Email: mvoevoda@ya.ru
акад. РАН, д.м.н., руководитель НИИТПМ - филиала ИЦиГ СО РАН Novosibirsk, Russia

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