Comorbidity and polymorbidity of the patient with chronic obstructive pulmonary disease and cardiovascular diseases


Cite item

Full Text

Abstract

Aim: the study of comorbid status and characteristics of clinical course of ischemic heart disease (IHD) in patients with chronic obstructive pulmonary disease (COPD). Materials and methods. We conducted a retrospective analysis of case histories of 958 IHD patients aged 32 to 93 years (mean age of 60.8±10.2 years), including men - 525 (54.8%), women - 433 (45.2%) who were treated in the cardiology Department of city clinical hospital №5 of Nizhny Novgorod. Related COPD was diagnosed in 251 patients (26.3%). We compared two groups patients: with IHD and COPD, and the second - persons suffering from only IHD (without COPD). Results. Myocardial infarction was transferred by 62.2% of patients in Group 1, which is 16.3% more than in Group 2 (p<0.05). Arterial hypertension in patients with COPD was 13.6% more frequent than in patients without COPD (p<0.05), and 6.4% more often (p<0.05), with comorbid pathology there was a chronic and paroxysmal forms of atrial fibrillation. In patients with IHD in combination with COPD it is 21.5% more often (p<0.05) than in IHD without COPD, there was shortness of breath and 32.1% more often (p<0.05) of the heartbeat. In patients with IHD with COPD, a higher level of was C-reactive protein detected (p<0.05) and more pronounced violations of the lipid profile (p<0.05). Conclusion. COPD makes a significant contribution to the development of the cardiovascular continuum, modifying its course. A modern patient with COPD is a high-risk patient with severe cardiovascular comorbidity and various polymorbidity.

About the authors

N Yu Grigoryeva

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, Department of faculty and outpatient therapya; City Clinical Hospital №5

Email: grigoreva28@mail.ru
д.м.н., проф. каф. факультетской и поликлинической терапии ФГБОУ ВО ПИМУ Минздрава России, кардиолог ГБУЗ НО ГКБ №5 Nizhny Novgorod, Russia

M V Maiorova

City Clinical Hospital №5

врач-кардиолог ГБУЗ НО ГКБ №5 Nizhny Novgorod, Russia

M E Korolyova

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, Department of faculty and outpatient therapy

аспирант каф. факультетской и поликлинической терапии ФГБОУ ВО ПИМУ Минздрава России Nizhny Novgorod, Russia

M O Samolyuk

Privolzhsky Research Medical University of the Ministry of Health of the Russian Federation, Department of faculty and outpatient therapy

аспирант каф. факультетской и поликлинической терапии ФГБОУ ВО ПИМУ Минздрава России Nizhny Novgorod, Russia

References

  1. Чучалин А.Г. Хроническая обструктивная болезнь легких и сопутствующие заболевания. Часть I. ХОБЛ и поражения сердечно - сосудистой системы. РМЖ. 2008;10:58-65.
  2. Buist A.S, Mc Burnie M.A, Vollmer W.M, et al. International variation in the prevalence of COPD (the BOLD Study): a population - based prevalence study. Lancet. 2007;370:741-50.
  3. Decramer M. Chronic obstructive pulmonary disease and comorbidities. Lancet Respir Med. 2013;1(1):73-83.
  4. Crisafulli E, Costi S, Luppi F, et al. Role of comorbidities in a cohort of patients with COPD undergoing pulmonary rehabilitation. Thorax. 2008; 63:487-92.
  5. Kokuvi Atsou, Christos Chouaid, Gilles Hejblum. Variability of the chronic obstructive pulmonary disease key epidemiological data in Europe: systematic review. BMC Med. 2011;9:7.
  6. Global Initiative for Chronic Obstructive Lung Diseases (GOLD). Global strategy for diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO workshop report. Updated 2017. www.goldcopd.org
  7. ATS/ERS. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respir J. 2004; 23:932-46.
  8. Milevoj Kopčinović L, Domijan A.M, Posavac K, Čepelak I, Žanić Grubišić T, Rumora L. Systemic redox imbalance in stable chronic obstructive pulmonary disease. Biomarkers. 2016;28:1-7.
  9. Ambrosino L. Clinical assessment of endothelial function in patients with chronic obstructive pulmonary disease: a systematic review with meta - analysis. Intern Emerg Med. 2017;5:877-85.
  10. Crisafulli E, Costi S, Luppi F, et al. Role of comorbidities in a cohort of patients with COPD undergoing pulmonary rehabilitation. Thorax. 2008; 63:487-92.
  11. Anthonisen N.R, Connett J.E, Enright P.L, Manfreda J. Lung Health Study Research Group. Hospitalizations and mortality in the Lung Health Study. Am J Respir Crit Care Med. 2002;166:333-9.
  12. Кароли Н.А., Ребров А.П. Хроническая обструктивная болезнь легких и кардиоваскулярная патология. Клиницист. 2007;1:13-9.
  13. Vicente L.San, Galofre N, Oriol J. Prevalence of heart disease in patients hospitalized for an acute exacerbation of COPD: impact on clinical outcome. A 6-month follow - up study. Eur J Heart Fail. 2011;10(1):152.
  14. Авдеев С.Н., Баймаканова Г.Е. Стратегия ведения кардиологического пациента, страдающего ХОБЛ. Кардиопульмонологические взаимоотношения. Сердце. 2007;6(6):305-9.
  15. Gan W.Q, Man S.F, Senthilselvan A, Sin D.D. The association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta - analysis. Thorax. 2004;59:574-80.
  16. Fischer B.M, Voynow J.A, Ghio A.J. COPD: balancing oxidants and antioxidants. Int J Chron Obstruct Pulmon Dis. 2015;10:76.
  17. Charlson M.E, Pompei P, Ales K, Mac Kenzie C.R. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40(5):373-83.
  18. Авдеев С.Н., Айсанов З.Р., Белевский А.С., Визель А.А., Зырянов С.К., Игнатова Г.Л., Княжеская Н.П., Лещенко И.В., Овчаренко С.И., Синопальников А.И., Степанян И.Э., Трофимов В.И. Новые возможности в профилактике обострений хронической обструктивной болезни легких. Заключение группы специалистов Российского респираторного общества. Пульмонология. 2017;27(1):108-13. https://doi.org/10.18093/0869-0189-2017-27-1-108-113

Copyright (c) 2019 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
 
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies