Genetic determinants of the development and course of membranous nephropathy


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Abstract

Membranous nephropathy (MN) is one of the most common causes of nephrotic syndrome in adults and is classified as either primary (idiopatic) or secondary MN according to underlying etiology (the later result from some known disease such as systemic autoimmune diseases, infections, malignancies, drugs, etc). In recent years, phospholipase A2 receptor 1 (PLA2R) and thrombospondin type-1 domain-containing 7A (THSD7A) were identified as two major podocytic antigens involved in the pathogenesis of idiopatic MN (IMN). And the discovery of circulating antibodies specific for these target antigens has transformed the diagnostic workup and significally improved management of IMN. However why do such antibodies develop is not conclusively established. The role of underlying genetic factors is discussed. The review presents the results of recent studies, that have shown significant associations of specific genetic factors (particularly human leucocyte antigen class II and PLA2R1 genes) with IMN.

About the authors

E S Kamyshova

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

Email: kamyshova-es@yandex.ru
к.м.н., ассистент каф. внутренних, профессиональных болезней и ревматологии медико-профилактического факультета; тел.: +7(916)344-48-38; e-mail: kamyshova-es@yandex.ru; ORCID 0000-0002-1823-0125 Moscow, Russia

I N Bobkova

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

д.м.н., проф. каф. внутренних, профессиональных болезней и ревматологии медико-профилактического факультета Moscow, Russia

I A Gorelova

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

аспирант, каф. внутренних, профессиональных болезней и ревматологии медико-профилактического факультета Moscow, Russia

P A Kakhsurueva

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

аспирант, каф. внутренних, профессиональных болезней и ревматологии медико-профилактического факультета Moscow, Russia

E E Filatova

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia (Sechenov University)

студентка Международной школы «Медицина будущего» научно-технологического парка биомедицины Moscow, Russia

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