Email this article Maternal incompatibilities with fetal human platelet alloantigens -1a, -1b and -15 are the main causes of neonatal alloimmune thrombocytopenia in Russia
- Authors: KHASPEKOVA SG1, GOLOVKINA LL2, DONUSH EK3, GOLUBEVA NV1, SHUSTOVA ON1, MAZUROV AV1
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Affiliations:
- National Medical Research Center for Cardiology, Russian Ministry of Health
- National Medical Research Center for Hematology, Russian Ministry of Health
- Russian Pediatric Clinical Hospital, Russian Ministry of Health
- Issue: Vol 90, No 7 (2018)
- Pages: 65-69
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/32783
- DOI: https://doi.org/10.26442/terarkh201890765-69
- ID: 32783
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Abstract
The aim. Mechanisms underlying the development of neonatal alloimmune thrombocytopenia (NAIT) in in Russia have been studied. Materials and methods. Genetic polymorphisms of human platelet alloantigens (HPA) -1, -2, -3, -4, -5, and -15 were evaluated in 27 families having the newborns with NAIT. NAIT was diagnosed according to the following criteria: (1) newborn with thrombocytopenia; (2) mother with no thrombocytopenia and no increase of platelet associated IgG, (3) presence of antibodies reacting with paternal platelets in maternal plasma / serum. HPA genotyping revealed incompatibilities in 23 out of 27 tested families. In these 23 families HPA-1 conflicts were detected in 16 ones (70%). In 8 cases mothers were homozygous carriers of rare HPA-1b allele and in another 8 cases - of HPA-1a allele which cased incompatibilities with fetal HPA-1a and HPA-1b respectively. In 5 out of 23 families (22%) there were incompatibilities with fetal HPA-15 (HPA-15a, n=2 and HPA-15b, n=3), in 1 family - with HPA-5b (4%), and in 1 family - with HPA-3b (4%) alloantigens. In conclusion the main causes of NAIT in Russia were HPA-1a and -1b conflicts and HPA-15 conflicts were the second frequent ones.
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##article.viewOnOriginalSite##About the authors
S G KHASPEKOVA
National Medical Research Center for Cardiology, Russian Ministry of Health
Email: svkh@list.ru
к.б.н., с.н.с. Moscow, Russia
L L GOLOVKINA
National Medical Research Center for Hematology, Russian Ministry of Healthд.м.н., врач-гематолог, рук. лаб. Moscow, Russia
E K DONUSH
Russian Pediatric Clinical Hospital, Russian Ministry of Healthк.м.н., врач-гематолог, зав. отделением Moscow, Russia
N V GOLUBEVA
National Medical Research Center for Cardiology, Russian Ministry of Healthн.с. Moscow, Russia
O N SHUSTOVA
National Medical Research Center for Cardiology, Russian Ministry of Healthм.н.с. Moscow, Russia
A V MAZUROV
National Medical Research Center for Cardiology, Russian Ministry of Healthд.б.н., проф., рук. лаб. Moscow, Russia
References
- Roberts I.A.G, Chakravotny S. Thrombocytopenia in the newborn. In Platelets. Third Edition. (Michelson A.D, editor). Amsterdam, Boston, Heidelberg et al. Elsivier. Academiv Press, 2013. P. 929-952. doi: 10.1161/CIRCRESAHA.113.300512
- Bussel J.B, Primiani A. Fetal and neonatal alloimmune thrombocytopenia: progress and ongoing debates. Blood Reviews. 2008; 22: 33-52. doi: 10.1080/17474086.2017.1346471
- Zdravic D, Yougbare I, Vadasz B, Li C, Marshall A.H, Chen P et al. Fetal and neonatal alloimmune thrombocytopenia. Seminars in Fetal & Neonatal Medicine. 2016; 21: 19-27. doi: 10.2147/IJWH.S90753
- Curtis B.R, Mc Farland J.G. Human platelet antigens - 2013. Vox Sanguinis. 2014; 106:93-102. doi: 10.1111/vox.12085
- Mueller-Eckhardt C, Kiefel V, Grubert A, Kroll H, Weisheit M, Schmidt S, Mueller-Eckhardt G, Santoso S. 348 cases of suspected neonatal alloimmune thrombocytopenia. Lancet. 1989; 1 (8634): 363-366. doi: 10,1016/S0140-6736(89)91733-9
- Ghevaert C, Campbell K, Walton J, Smith G.A, Allen D, Williamson L.M, Ouwehand W.H, Ranasinghe E. Management and outcome of 200 cases of fetomaternal alloimmune thrombocytopenia. Transfusion. 2007; 47: 901-910. doi: 10.1111/j.1537-2995.2007.01208.
- Ohto H, Miura S, Ariga H, Ishii T, Fujimori K, Morita S. The natural history of maternal immunization against foetal platelet alloantigens. Transfus Med. 2004; 14:399-408. doi: 10.1111/j.1365-3148.2004. 00535.x
- Kuznetsov A.I, Ivanov A.L, Idelson L.I, Mazurov A.V. Different mechanisms of thrombocytopenia in patients with lymphoproliferative disorders. Eur J Haematol. 1992; 49: 113-118. doi: 10.1111/j.1600-0609.1992.tb00913.x
- Khaspekova S.G, Shustova O.N, Golubeva N.V, Vasiliev S.A, Mazurov A.V. Relationships of mean platelet volume and plasma thrombopoietin with glycocalicin levels in thrombocytopenic patients. Acta Haematologica. 2015; 133: 295-299. doi: 10.1159/000362531
- Berry J.E, Murphy C.M, Smith G.A, Ranasinghe E, Finberg R, Walton J, Brown J, Navarrete C, Metcalfe P, Ouwehandet W.H. Detection of Gov system antibodies by MAIPA reveals an immunogenicity similar to the HPA-5 alloantigens. Br J Haematol. 2000; 110: 735-742. doi: 10.1046/j.1365-2141.2000.02170.x
- Ertel K, Al-Tawil M, Santoso S, Kroll H. Relevance of the HPA-15 (Gov) polymorphism on CD109 in alloimmune thrombocytopenic syndromes. Transfusion. 2005; 45: 366-373. doi: 10.1159/000092578
- Golovkina L.L, Makarik T, Sudarikov A.B. Distribution of HPA-genes and genotypes in the population of Russian unrelated donors. Genes and Immunity. 2005; 6(Suppl 1): S22. Special Issue: Abstracts of the 19th European Immunogenetics & Histocompatibility Conference. p. 36. doi: 10.1186/s40851-015-0013-4
- Пчелина С.Н., Сироткина О.В., Шейдина А.М., Тараскина А.Е., Родыгина Т.И., Демина Е.П., Заботина А.М., Митупова М.И., Баженова Е.А., Беркович О.А., Шляхто Е.В., Шварцман А.Л., Шварц Е.И. Генетические факторы риска развития инфаркта миокарда у мужчин молодого возраста в северо - западном регионе России. Кардиология. 2007; 47.
- Golovkina L.L, Atroshchenko G, Pushkina T. Immunogenetic parameters of HPA in Russian unrelated donors. Vox Sanguinis. 2010; 99 (Suppl):s2. Special Issue: Abstracts of the XIth European Symposium on Platelet and Granulocyte Immunobiology. p. 43.
- Головкина Л.Л., Атрощенко Г.В., Пушкина Т.Д., Михайлова Е.А., Исаев В.Г. Распределение HPA-генов у больных и относительный риск аллоиммунизации при трансфузиях тромбоцитов. Трансфузиология. 2011; 12(2): 36-37.
- Хамаганова Е.Г, Кузьминова Е.П., Чапова Р.С., Гапонова Т.В., Савченко В.Г. HLA-A*/B*C*/DRB1*/DQB1*-гены и гаплотипы у доноров костного мозга регистра ФГБУ «Гематологический научный центр» Минздрава России, самоопределившихся как русские. Гематология и трансфузиология. 2017; 62 (2): 65-70. doi: 10.1182/blood-2007-02-071282. doi: 10.1182/blood-2007-02-071282
- Golovkina L.L, Pushkina T.D, Mikhailova E.A, Savchenko V.G. Genetic risk factors in humoral immune response to platelet antigens HLA and HPA systems in multitransfused hematological patients. Haematologica. 2015; 100(Suppl): s1. Special Issue: Abstracts of the 20-th Congress of the European Hematology Association. p. 630. doi: 10.5581/1516-8484.20120043
- Ikeda Y, Matsubara Y, Kamata T. Platelet immunology: structure, functions and polymorphism of membrane glycoproteins. In: Platelets in hematologic and cardiovascular disorders. (Gesele P, Fuster V, Lopez J.A, Page C.P, Vermylen J, ed). Cambridge: Cambridge University Press; 2008. P. 21-36. doi: 10.20471/apr.2017.53.01.04
