Personalized strategies in reproductive medicine for patients with endocrine disorders


Cite item

Full Text

Abstract

Endocrine Medical Research center (EMRC) of the Ministry of health of Russia is unique clinical center, that have no analogs in the world. All forms of endocrine disorders may be diagnosed and treated here by implication of innovative methods. Institute of reproductive medicine of EMRC was open on 2017, director of this institute - MD, PhD E.N. Andreeva. Staff of this institute include highly experienced investigators and physicians. One of the most ambitious projects of the institute is development of prevention, diagnostic and treatment algorithm for patients with infertility of endocrine origin. For these purposes large prospective clinical trial (5000 patients) will be conducted with implementation of most modern genetic, laboratory and instrumental diagnostic methods. Results of this trial will allow diagnose, treat and prevent reproductive pathology in patients with endocrine diseases.

About the authors

O R Grigoryan

Endocrine Medical Research center Ministry of Health of Russia

Email: iceberg1995@mail.ru
д.м.н., гл. науч. сотр. отд. эндокринной гинекологии Института репродуктивной медицины ФГБУ «НМИЦ эндокринологии» Moscow, Russia

E N Andreeva

Endocrine Medical Research center Ministry of Health of Russia

д.м.н., проф., зав. отд. эндокринной гинекологии, директор Института репродуктивной медицины ФГБУ «НМИЦ эндокринологии» Moscow, Russia

I I Dedov

Endocrine Medical Research center Ministry of Health of Russia

д.м.н., проф., академик РАН, директор ФГБУ «НМИЦ эндокринологии» Moscow, Russia

References

  1. Reproductive health. WHO. Available at: http://www.who.int/topics/reproductive_health/en/. Accessed May 22, 2017.
  2. Кондратьева Т.А., Артымук Н.В. Современные подходы к диагностике и лечению бесплодия. Мать и дитя в Кузбассе. 2009;(2):3-7
  3. Weiss R.V, Clapauch R. Female infertility of endocrine origin. Arq Bras Endocrinol Metabol. 2014;58(2):144-52. doi: 10.1590/0004-2730000003021
  4. Ring J.D, Lwin A.A, Köhler T.S. Current medical management of endocrine - related male infertility. Asian J Androl. 2016;18(3):357-63. doi: 10.4103/1008-682X.179252
  5. Wang H, Gorpudolo N, Behr B. The role of prolactin - and endometriosis - associated infertility. Obstet Gynecol Surv. 2009;64(8):542-7. doi: 10.1097/ogx.0b013e3181ab5479
  6. Aitken R.J, Baker M.A. Oxidative stress, sperm survival and fertility control. Mol Cell Endocrinol. 2006;250(1-2):66-9. doi: 10.1016/j.mce. 2005.12.026
  7. Agbaje I.M, Rogers D.A, Mc Vicar C.M, Mc Clure N, Atkinson A.B, Mallidis C, Lewis S.E. Insulin dependant diabetes mellitus: implications for male reproductive function. Hum Reprod. 2007;22(7):1871-7. doi: 10.1093/humrep/dem077
  8. Alves M.G, Martins A.D, Rato L, Moreira P.I, Socorro S, Oliveira P.F. Molecular mechanisms beyond glucose transport in diabetes - related male infertility. Biochim Biophys Acta. 2013;1832(5):626-35. doi: 10.1016/j.bbadis.2013.01.011
  9. Caburet S, Zavadakova P, Ben-Neriah Z, Bouhali K, Dipietromaria A, Charon C, et al. Genome - wide linkage in a highly consanguineous pedigree reveals two novel loci on chromosome 7 for non - syndromic familial Premature Ovarian Failure. PLoS One. 2012;7(3):e33412. doi: 10.1371/journal.pone.0033412
  10. Knauff E.A, Franke L, van Es M.A, van den Berg L.H, van der Schouw Y.T, Laven J.S, et al. Genome - wide association study in premature ovarian failure patients suggests ADAMTS19 as a possible candidate gene. Hum Reprod. 2009 Sep;24(9):2372-8. doi: 10.1093/humrep/ dep197
  11. Perry J.R, Corre T, Esko T, Chasman D.I, Fischer K, Franceschini N, et al. A genome - wide association study of early menopause and the combined impact of identified variants. Hum Mol Genet. 2013;22(7):1465-72. doi: 10.1093/hmg/dds551
  12. Chang C.Y, Chen Y, Lin W.C, Chen C.M, Chen C.P, Lee S.C, et al. MUC2 polymorphisms are associated with endometriosis development and infertility: a case - control study. BMC Med Genet. 2012;13:15. doi: 10.1186/1471-2350-13-15
  13. Wang Y.A, Healy D, Black D, Sullivan E.A. Age - specific success rate for women undertaking their first assisted reproduction technology treatment using their own oocytes in Australia, 2002-2005. Hum Reprod. 2008;23(7):1633-8. doi: 10.1093/humrep/den135
  14. Turkyilmaz E, Guner H, Erdem M, Erdem A, Biri A.A, Konac E. NLF2 gene expression in the endometrium of patients with implantation failure after IVF treatment. Gene. 2012 Oct 15;508(1):140-3. doi: 10.1016/j.gene.2012.07.031
  15. Ewens K.G, Jones M.R, Ankener W, Stewart D.R, Urbanek M, Dunaif A, et al. FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome. PLoS One. 2011;6(1):e16390. doi: 10.1371/journal.pone.0016390
  16. Zurawek M, Wender-Ozegowska E, Januszkiewicz-Lewandowska D, Zawiejska A, Nowak J. GCK and HNF1alpha mutations and polymorphisms in Polish women with gestational diabetes. Diabetes Res Clin Pract. 2007;76(1):157-8. doi: 10.1016/j.diabres.2006.08.001
  17. Beim P.Y, Elashoff M, Hu-Seliger T.T. Personalized reproductive medicine on the brink: progress, opportunities and challenges ahead. Reprod Biomed Online. 2013;27(6):611-23. doi: 10.1016/j.rbmo. 2013.09.010

Copyright (c) 2018 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
 
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies