Differences between passport and biological (actual) age in the population of Russian patients suffering from arterial hypertension (analysis of the «Hyperion» register)


Cite item

Full Text

Abstract

The age of the patient is the most important factor determining the high risk of cardiovascular diseases. The subject of modern research was the study of the clinical role of the patient's biological age and its difference from passport age. The aim of the study was to analyze the severity of the difference in these values in real clinical practice in patients suffering from arterial hypertension (AH) on the basis of an open multicenter register to monitor the effectiveness of therapy in patients with hypertension "HYPERION", conducted by the Eurasian Association of Therapists with the support of the company "Gedeon Richter" (Hungary). Materials and methods. The study was carried out within the open multi-center register "HYPERION". The final analysis of the register included 1441 patients, including 638 men (44%), 803 women (56%) aged 24 to 90 years. All patients were observed in primary health care (55 centers in 47 cities of Russia) for hypertension, received at least two hypotensive drugs. According to the data on 1424 patients using the qrisk-2 scale of 2017 modification, the biological age was calculated. Results and discussion. The absolute majority of patients (83,7%) had biological age >70 years, while the passport age of the absolute majority (65,3%) is in the range ≥50, but ≤69 years. Median difference between biological and passport age was 15 years. On average, in men suffering from hypertension, the biological age exceeded the passport age by 17.6 years, and in women - by 13.4 years. The difference between the value of biological and passport age and the level of systolic pressure in all age groups had a direct correlation. At systolic blood pressure >181 mm Hg. the difference between biological and passport age was the maximum, reaching the highest values in the youngest age group (30-39 years). Conclusion. Analysis of the actual (biological) age should be a mandatory procedure that allows a more complete assessment of the initial therapeutic status of the patient, which is especially important in patients aged 30-50 years. This is necessary not only from the standpoint of changing the current procedure, but also to understand the patient's prognosis.

About the authors

A G Arutyunov

N.I.Pirogov Russian National Research Medical University, Ministry of Health of Russia

Email: agarutyunov@mail.ru
д.м.н., проф. каф. пропедевтики внутренних болезней РНИМУ им. Н.И. Пирогова Moscow, Russia

A V Nozdrin

"IPT Medicine"

сотрудник аналитической группы ООО «Ай Пи Ти Медицина» Moscow, Russia

K B Shavgulidze

Medical center GMS Clinic

к.м.н., зав. терапевтическим стационаром GMS Clinic Moscow, Russia

D S Tokmin

"IPT Medicine"

сотрудник аналитической группы ООО «Ай Пи Ти Медицина» Moscow, Russia

I V Osadchiy

"IPT Medicine"

сотрудник аналитической группы ООО «Ай Пи Ти Медицина» Moscow, Russia

References

  1. Collins G.S, Altman D.G. Predicting the 10 year risk of cardiovascular disease in the United Kingdom: independent and external validation of an updated version of QRISK2. BMJ. 2012;344:e4181.
  2. Hoogendijk E.O, Deeg D.J, Poppelaars J, van der Horst M, Broese van Groenou M, Comijs H.C, et al. The Longitudinal Aging Study Amsterdam: cohort update 2016 and major findings. Eur J Epidemiol. 2016;31(9):927-45. doi: 10.1007/s10654-016-0192-0
  3. Post H.G, Smulders Y.M, Maier A.B, Deeg D.J, Muller M. Relation between blood pressure and mortality risk in an older population: role of chronological and biological age. J Intern Med. 2015;277(4):488-97. doi: 10.1111/joim.12284
  4. Muller M, Smulders Y.M, de Leeuw P.W, Stehouwer C.D. Treatment of hypertension in the oldest old: a critical role for frailty? Hypertension. 2014;63:433-41. doi: 10.1161/HYPERTENSIONAHA.113.00911
  5. Odden M.C, Peralta C.A, Haan M.N, Covinsky K.E. Rethinking the association of high blood pressure with mortality in elderly adults: the impact of frailty. Arch Intern Med. 2012;172:1162-8. doi: 10.1001/archinternmed.2012.2555
  6. Sabayan B, van Vliet P, de Ruijter R.W, Gussekloo J, de Craen A.J, Westendorp R.G. High blood pressure, physical and cognitive function, and risk of stroke in the oldest old: the Leiden 85-plus Study. Stroke. 2013;44:15-20. doi: 10.1161/STROKEAHA.112.663062
  7. Rabkin S.W, Waheed A, Poulter R.S, Wood D. Myocardial perfusion pressure in patients with hypertension and coronary artery disease: implications for DBP targets in hypertension management. J Hypertens. 2013;31:975-82. doi: 10.1097/HJH.0b013e32835e831c
  8. Dorresteijn J.A, van der Graaf Y, Spiering W, Grobbee D.E, Bots M.L, Visseren F.L. Relation between blood pressure and vascular events and mortality in patients with manifest vascular disease: J-curve revisited. Hypertension. 2012;59:14-21. doi: 10.1161/HYPERTENSIONAHA. 111.179143
  9. Morgan E.L. Modeling the Rate of Senescence: Can Estimated Biological Age Predict Mortality More Accurately Than Chronological Age? J Gerontol A Biol Sci Med Sci. 2013;68(6):667-74. doi: 10.1093/ gerona/gls233
  10. Klemera P, Doubal S. A new approach to the concept and computation of biological age. Mech Ageing Dev. 2006;127:240-8. doi: 10.1016/ j.mad.2005.10.004
  11. Sebastiani P, Thyagarajan B, Sun F, Schupf N, Newman A.B, Montano M, Perls Т.Т. Biomarker signatures of aging. Aging Cell. 2017; 16(2):329-38. doi: 10.1111/acel.12557
  12. Belsky D.W, Caspi A, Houts R, Cohen H.J, Corcoran D.L, Danese А. Quantification of biological aging in young adults. Proc Natl Acad Sci U S A. 2015;112(30):E4104-E4110. doi: 10.1073/pnas.1506264112
  13. Finegold J.A, Asaria P, Francis D.P. Mortality from ischaemic heart disease by country, region, and age: statistics from World Health Organisation and United Nations. Int J Cardiol. 2013;168:934-45. doi: 10.1016/j.ijcard.2012.10.046
  14. Sun Z. Aging, arterial stiffness, and hypertension. Hypertension. 2015;65:252-6. doi: 10.1161/HYPERTENSIONAHA.114.03617
  15. Fedintsev A, Kashtanova D, Tkacheva O, Strazhesko I, Kudryavtseva A, Baranova A, Moskalev A. Markers of arterial health could serve as accurate non - invasive predictors of human biological and chronological age. Aging (Albany NY). 2017;9(4):1280-92. doi: 10.18632/aging.101227
  16. Yang J, Huang T, Petralia F, Long Q, Zhang B, Argmann C, Zhao Y, Mobbs C.V, Schadt E.E, Zhu J, Tu Z, Ardlie K.G, Deluca D.S, et al. GTEx Consortium Synchronized age - related gene expression changes across multiple tissues in human and the link to complex diseases. Sci Rep. 2015;5:15145. doi: 10.1038/srep15145
  17. Al-Ghatrif M, Strait J.B, Morrell C.H, Canepa M, Wright J. Longitudinal Trajectories of Arterial Stiffness and the Role of Blood Pressure The Baltimore Longitudinal Study of Aging. Hypertension. 2013;62:934-41. doi: 10.1161/HYPERTENSIONAHA.113.01445
  18. Sehgel N.L, Sun Z, Hong Z, Hunter W.C, Hill M.A, Vatner D.E, Vatner S.F, Meininger G.A. Augmented Vascular Smooth Muscle Cell Stiffness and Adhesion When Hypertension Is Superimposed on Aging. Hypertension. 2014;65(2):370. doi: 10.1161/HYPERTENSIONAHA.114. 04456
  19. Handy C.E, Desai C.S, Dardari Z.A, Al-Mallah M.H, Miedema M.D, Ouyang P, Budoff M.J, Blumenthal R.S, Nasir K, Blaha M.J. The Association of Coronary Artery Calcium With Noncardiovascular Disease: The Multi-Ethnic Study of Atherosclerosis. JACC Cardiovasc Imaging. 2016;9:568-76. doi: 10.1016/j.jcmg.2015.09.020
  20. Zheng Y, Joyce B.T, Colicino E, Liu L, Zhang W, Dai Q, et al. Blood Epigenetic Age may Predict Cancer Incidence and Mortality. EBioMedicine. 2016;5:68-73. doi: 10.1016/j.ebiom.2016.02.008
  21. Van Staa T-P, Gulliford M, Ng E.S-W, Goldacre B, Smeeth L. Prediction of Cardiovascular Risk Using Framingham, ASSIGN and QRISK2: How Well Do They Predict Individual Rather than Population Risk? PLoS One. 2014;9(10):e106455. doi: 10.1371/journal. pone.0106455
  22. Harvey A, Montezano A.C, Touyz R.M. Vascular biology of ageing - Implications in hypertension. J Mol Cell Cardiol. 2015;83:112-21. doi: 10.1016/j.yjmcc.2015.04.011
  23. Costantino S, Paneni F, Cosentino F. Ageing, metabolism and cardiovascular disease. J Physiol. 2016;594(8):2061-73. doi: 10.1113/ JP270538
  24. Hippisley-Cox J, Coupland C, Vinogradova Y, Robson J, Minhas R, Sheikh A, Brindle P. Predicting cardiovascular risk in England and Wales: prospective derivation and validation of QRISK2. BMJ. 2008;336:1475-82. doi: 10.1136/bmj.39609.449676.25

Copyright (c) 2018 Consilium Medicum

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License.
 
 


This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies