Minimal-change glomerulonephritis in chronic lymphocytic leukemia
- Authors: Dzhumabaeva BT1, Biryukova LS1, Golitsyna EP2, Varshavsky VA2
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Affiliations:
- «Гематологический научный центр» Минздрава России
- «Первый МГМУ им. И.М. Сеченова» Минздрава России
- Issue: Vol 87, No 12 (2015)
- Pages: 85-88
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/31885
- ID: 31885
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Abstract
Chronic lymphocytic leukemia (CLL) in association with glomerulonephritis (GN) and renal failure is a serious problem in terms of therapy. The paper reports a clinical case of a 64-year-old female patient with Binet stage C CLL accompanied by minimal-change GN complicated by nephrotic syndrome and the development of acute renal failure. GN was diagnosed on the basis of electron microscopic studies of renal biopsy specimens. It was treated with rituximab in combination with bendamustine. The former was intravenously injected in a dose of 375 mg/m2 on day 0 of the cycle; the latter was given in a dose of 70 mg/m2 within the first 2 days; the cycle was repeated 28 days after initiation of the previous cycle. Five cycles could result in complete CLL remission (the follow-up duration was 20 months); nephrotic syndrome was completely abolished and kidney function recovered.
About the authors
B T Dzhumabaeva
«Гематологический научный центр» Минздрава РоссииМосква, Россия
L S Biryukova
«Гематологический научный центр» Минздрава РоссииМосква, Россия
E P Golitsyna
«Первый МГМУ им. И.М. Сеченова» Минздрава РоссииМосква, Россия
V A Varshavsky
«Первый МГМУ им. И.М. Сеченова» Минздрава РоссииМосква, Россия
References
- Barcos M, Lane W, Gomez GA, Han T, Freeman A, Preisler H, Henderson E. An autopsy study of 1206 acute and chronic leukemias (1958 to 1982). Cancer. 1987;60:827-837.
- Norris HJ, Wiener J. The renal lesions in leukemia. Am J Med Sci. 1961;241:512-518.
- Schwartz JB, Shamsuddin AM. The effects of leukemic infiltrates in various organs in chronic lymphocytic leukemia. Human Pathol. 1981;12:432-440.
- Бирюкова Л.С., Джумабаева Б.Т., Даумова В.Б., Звонков Е.Е., Кременецкая А.М., Капланская И.Б., Варламова Е Ю., Воробьев И.А., Грецов Е.М., Кравченко С.К., Мосешвили Э.Г., Ахметшин Р.Б. Аллогенная трансплантация почки у больного с В-мелкоклеточной лимфомой и хронической почечной недостаточностью. Терапевтический архив. 2006;10: 48-51.
- Рехтина И.Г., Бирюкова Л.С. Болезнь легких цепей. Нефрология и диализ. 2005;4:422-427.
- Голицин Е.П. Варшавский В.А., Бочарникова А.В., Рехтина И.Г. Фибриллярный гломерулонефрит и иммуноактоидная нефропатия: современный взгляд на патоморфологический субстрат болезни. Архив патологии. 2011;73(3):54-58.
- Moulin B, Ronco PM, Mougenot B, Francois A, Fillastre JP, Mignon F. Glomerulonephritis in chronic lymphocytic leukemia and related B-cell lymphomas. Kidney Int. 1992;14:127-135.
- Stokes MB, Wood B, Alpers CE. Membranoproliferative glomerulonephritis associated with low-grade B cell lymphoma presenting in the kidney. Clin Nephrol. 2002;14:303-309.
- Nasr SH, Fidler ME, Cornell LD, Leung N., Cosio FG, Sheikh SS, Amir AA, Vrana JA, Theis JD, Dogan A, Sethi S. Immunotactoid glomerulopathy: clinicopathologic and proteomic study. NephrolDial Transplant. 2012;27(11):4137-4146. doi: 10.1093/ndt/gfs348.
- Mutluay R, Aki SZ, Erten Y, Konca C, Yagci M, Barit G, Sindel S. Membranoproliferative glomerulonephritis and light-chain nephropathy in association with chronic lymphocytic leukemia. Clin Nephrol. 2008;70(6):527-531.
- Cohen LJ, Rennke HG, Laubach JP. Humphreys BD. The spectrum of kidney involvement in lymphoma: a case report and review of the literature. Am J Kidney Dis. 2010;14:1191-1196. doi: 10.1053/j.ajkd.2010.07.009.
- Khow KS, Yong AS, Yong TY, Kuss BJ, Barbara JA, Li JY. Minimal change disease associated with newly diagnosed mantle cell lymphoma. Ren Fail. 2014;36(4):634-637. doi: 10.3109/0886022x.2014.883905.
- Rosas SE, Tomaszewski JE, Feldman HI, Foster MH. Membranoproliferative glomerulonephritis type 1, mixed cryoglobulinemia and lymphoma in the absence of hepatitis C infection. Am J Nephrol. 1999;19:599-604.
- Smith, Alpers KD, Charles E. Pathogenic mechanisms in membranoproliferative glomerulonephritis. Curr Opin NephrolHypertens. 2005;14:396-403.
- Ronco PM. Paraneoplastic glomerulopathies: new insights into an old entity. Kidney Int. 1999;56:355-377.