Use of nonsteroidal anti-inflammatory drugs in case of ankylosing spondylitis: Long and persistently!
- Authors: Karateev AE1, Érdes S.F1
-
Affiliations:
- ФГБУ "НИИ ревматологии им. В.А. Насоновой" РАМН, Москва
- Issue: Vol 86, No 11 (2014)
- Pages: 123-127
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/31665
- ID: 31665
Cite item
Full Text
Abstract
Nonsteroidal anti-inflammatory drugs (NSAIDs) are extensively used in the treatment of rheumatic diseases to relieve pain and signs of inflammation. However, when treated for ankylosing spondylosis (AS), NSAIDS exert both symptomatic and structure-modifying effects, by slowing down the development of vertebral ankylosis. The effect of these drugs, which underlines the formation of syndesmophytes, may be associated with their anti-inflammatory activity and ability to suppress abnormal bone proliferation. There is convincing evidence to support the capacity of NSAIDs, when long and continuously used, to reduce the rates of X-ray progression of AS. So the continuous use of NSAIDs must be now considered to be a mandatory component of pharmacotherapy for this disease. Their use should be continued even after achieving a marked clinical improvement. At the same time, this situation requires that the development of adverse reactions as structural and functional diseases of the gastrointestinal tract and cardiovascular system be thoroughly controlled in this situation. The danger of these complications determines the need for a physician's attention, obligatory consideration of risk factors, and rational choice of the safest NSAIDs.
Full Text
##article.viewOnOriginalSite##About the authors
A E Karateev
ФГБУ "НИИ ревматологии им. В.А. Насоновой" РАМН, Москва
Email: aekarateev@rambler.ru
Sh F Érdes
ФГБУ "НИИ ревматологии им. В.А. Насоновой" РАМН, Москва
References
- Насонов Е.Л. Анальгетическая терапия в ревматологии: путешествие между Сциллой и Харибдой. Клин фармакол тер 2003; 1: 64-69.
- Burmester G., Lanas A., Biasucci L. et al. The appropriate use of non-steroidal anti-inflammatory drugs in rheumatic disease: opinions of a multidisciplinary European expert panel. Ann Rheum Dis 2011; 70 (5): 818-822.
- Ревматология. Клинические рекомендации. Под ред. Е.Л. Насонова. М: ГЭОТАР-Медиа 2010; 752.
- Эрдес Ш. Некоторые аспекты патогенеза анкилозирующего спондилита. Тер арх 2011; 5: 51-56.
- Toussirot E., Wendling D. The immunogenetics of ankylosing spondylitis. Rev Med Int 2006; 27 (10): 762-771.
- Brown M. Genetics and the pathogenesis of ankylosing spondylitis. Curr Opin Rheumatol 2009; 21 (4): 318-323.
- Siegle I., Klein T., Backman J. et al. Expression of cyclooxygenase 1 and cyclooxygenase 2 in human synovial tissue: differential elevation of cyclooxygenase 2 in inflammatory joint diseases. Arthritis Rheum 1998; 41 (1): 122-129.
- Roberts S., Butler R. Inflammatory mediators as potential therapeutic targets in the spine. Curr Drug Targets Inflamm Allergy 2005; 4 (2): 257-266.
- Vandooren B., Yeremenko N., Noordenbos T. et al. Mediators of structural remodeling in peripheral spondylarthritis. Arthr Rheumat 2009; 60 (12): 3534-3545.
- Бунчук Н.В. Анкилозирующий спондилит: новые возможности и перспективы фармакотерапии. Фарматека 2006; 6: 26-31.
- Maksymowych W. Disease modification in ankylosing spondylitis. Nat Rev Rheumatol 2010; 6 (2): 75-81.
- Gensler L., Inman R., Deodhar A. The "knowns" and "unknowns" of biologic therapy in ankylosing spondylitis. Am J Med Sci 2012; 343 (5): 360-363.
- van der Heijde D., Landewe R., Baraliakos X. et al. Radiographic findings following two years of infliximab therapy in patients with ankylosing spondylitis. Arthritis Rheum 2008; 58: 3063-3070.
- van der Heijde D., Landewe R., Einstein S. et al. Radiographic progression of ankylosing spondylitis after up to two years of treatment with etanercept. Arthritis Rheum 2008; 58: 1324-1331.
- van der Heijde D., Salonen D., Weissman B. et al. Assessment of radiographic progression in the spines of patients with ankylosing spondylitis treated with adalimumab for up to 2 years. Arthritis Res Ther 2009; 11: R127.
- Бочкова А.Г. Особенности применения нестероидных противовоспалительных препаратов при спондилоартритах. Consilium Medicum 2010; 12 (9): 13-18.
- Poddubnyy D., Song I., Sieper J. A systematic comparison of rheumatoid arthritis and ankylosing spondylitis: non-steroidal anti-inflammatory drugs. Clin Exp Rheumatol 2009; 27 (4 Suppl 55): 148-151.
- Kroon F., Landewé R., Dougados M., van der Heijde D. Continuous NSAID use reverts the effects of inflammation on radiographic progression in patients with ankylosing spondylitis. Ann Rheum Dis 2012; 71 (10): 1623-1629.
- Каратеев А.Е., Яхно Н.Н., Лазебник Л.Б. и др. Применение нестероидных противовоспалительных препаратов. Клинические рекомендации. М: ИМА-Пресс 2009; 167.
- Leahy K., Koki A., Masferrer J. Role of cyclooxygenases in angiogenesis. Curr Med Chem 2000; 7 (11): 1163-1170.
- Walsh D.A., Haywood L. Angiogenesis: a therapeutic target in arthritis. Curr Opin Invest Drugs 2001; 2: 1054-1063.
- Semerano L., Clavel G., Assier E. et al. Blood vessels, a potential therapeutic target in rheumatoid arthritis? Joint Bone Spine 2011; 78 (2): 118-123.
- Gately S., Li W. Multiple roles of COX-2 in tumor angiogenesis: a target for antiangiogenic therapy. Semin Oncol 2004; 31 (2 Suppl 7): 2-11.
- Gheorghe K., Thurlings R., Westman M. et al. Prostaglandin E2 synthesizing enzymes in rheumatoid arthritis B cells and the effects of B cell depleting therapy on enzyme expression. PLoS One 2011; 27: 6 (1): e16378.
- Kunisch E., Jansen A., Kojima F. et al. Prostaglandin E2 differentially modulates proinflammatory/prodestructive effects of TNF-alpha on synovial fibroblasts via specific E prostanoid receptors/cAMP. J Immunol 2009; 183 (2): 1328-1336.
- Murn J., Alibert O., Wu N. et al. Prostaglandin E2 regulates B cell proliferation through a candidate tumor suppressor, Ptger4. J Exp Med 2008; 205 (13): 3091-3103.
- Pohl F., Seufert J., Tauscher A. et al. The influence of heterotopic ossification on functional status of hip joint following total hip arthroplasty. Strahlenther Onkol 2005; 181 (8): 529-533.
- Iorio R., Healy W. Heterotopic ossification after hip and knee arthroplasty: risk factors, prevention, and treatment. J Am Acad Orthop Surg 2002; 10 (6): 409-416.
- Fransen M., Neal B. Non-steroidal anti-inflammatory drugs for preventing heterotopic bone formation after hip arthroplasty. Cochrane Database Syst Rev 2004; (3): CD001160.
- Moore R., Moore O., Derry S. et al. Responder analysis for pain relief and numbers needed to treat in a meta-analysis of etoricoxib osteoarthritis trials: bridging a gap between clinical trials and clinical practice. Ann Rheum Dis 2010; 69: 374-379.
- van der Heijde D., Baraf H., Ramos-Remus C. et al. Evaluation of the efficacy of etoricoxib in ankylosing spondylitis: results of a fifty-two-week, randomized, controlled study. Arthritis Rheum 2005; 52 (4): 1205-1215.
- Dougados M., Béhier J., Jolchine I. et al. Efficacy of celecoxib, a cyclooxygenase 2-specifi c inhibitor, in the treatment of ankylosing spondylitis: a six-week controlled study with comparison against placebo and against a conventional nonsteroidal antiinflammatory drug. Arthritis Rheum 2001; 44: 180-185.
- Sieper J., Lenaerts J., Wollenhaupt J. et al. Efficacy and safety of infliximab plus naproxen versus naproxen alone in patients with early, active axial spondyloarthritis: results from the double-blind, placebo-controlled INFAST study, Part 1. Ann Rheum Dis 2014; 73 (1): 101-107.
- Boersma J. Retardation of ossification of the lumbar vertebral column in ankylosing spondylitis by means of phenylbutazone. Scand J Rheumatol 1976; 5 (1): 60-64.
- Wanders A., Heijde D., Landewé R. et al. Nonsteroidal antiinflammatory drugs reduce radiographic progression in patients with ankylosing spondylitis: a randomized clinical trial. Arthritis Rheum 2005; 52 (6): 1756-1765.
- Haroon N., Shen H., Carty A. et al. Continuance of Non-Steroidal Anti-Inflammatory Drugs May Reduce Radiographic Progression in Ankylosing Spondylitis Patients on Biological Therapy [abstract]. Arthritis Rheum 2011; 63 Suppl 10: 1303
- Poddubnyy D., Rudwaleit M., Haibel H. et al. Effect of non-steroidal anti-inflammatory drugs on radiographic spinal progression in patients with axial spondyloarthritis: results from the German Spondyloarthritis Inception Cohort. Ann Rheum Dis 2012 Mar 29. doi: 10.1136/annrheumdis-2011-201252
- Blachier M., Canouï-Poitrine F., Dougados M. et al. Factors associated with radiographic lesions in early axial spondyloarthritis. Results from the DESIR cohort. Rheumatology (Oxford) 2013; 52 (9): 1686-1693.
- Poddubnyy D., van der Heijde D. Therapeutic controversies in spondyloarthritis: nonsteroidal anti-inflammatory drugs. Rheum Dis Clin North Am 2012; 38 (3): 601-611.
- Ward M. Prospects for Disease Modification in Ankylosing Spondylitis: Do Nonsteroidal Antiinflammatory Drugs Do More Than Treat Symptoms? Arthrit Rheum 2005; 52 (6): 1634-6136.
- Dougados M., Simon P., Braun J. et al. ASAS recommendations for collecting, analysing and reporting NSAID intake in clinical trials/epidemiological studies in axial spondyloarthritis. Ann Rheum Dis 2011; 70 (2): 249-251.
- Song I., Poddubnyy D., Rudwaleit M., Sieper J. Benefits and Risks of Ankylosing Spondylitis Treatment With Nonsteroidal Antiinflammatory Drugs. Arthrit Rheum 2008; 58 (4): 929-938.
- Каратеев А.Е., Насонова В.А. Развитие и рецидивирование язв желудка и двенадцатиперстной кишки у больных, принимающих нестероидные противовоспалительные препараты: влияние стандартных факторов риска. Тер арх 2008; 5: 62-66.
- Zochling J., Bohl-Bühler M., Baraliakos X. et al. Nonsteroidal anti-inflammatory drug use in ankylosing spondylitis - a population-based survey. Clin Rheumatol 2006; 25 (6): 794-800.
- Van Praet L., Van den Bosch F., Jacques P. et al. Microscopic gut inflammation in axial spondyloarthritis: a multiparametric predictive model. Ann Rheum Dis 2013; 72 (3): 414-417.
- Jacques P., Elewaut D., Mielants H. Interactions between gut inflammation and arthritis/spondylitis. Curr Opin Rheumatol 2010; 22 (4): 368-374.
- Porzio V., Biasi G., Corrado A. et al. Intestinal histological and ultrastructural inflammatory changes in spondyloarthropathy and rheumatoid arthritis. Scand J Rheumatol 1997; 26 (2): 92-98.
- Papagoras C., Voulgari P., Drosos A. Atherosclerosis and cardiovascular disease in the spondyloarthritides, particularly ankylosing spondylitis and psoriatic arthritis. Clin Exp Rheumatol 2013; 31 (4): 612-620.
- Nurmohamed MT., van der Horst-Bruinsma I., Maksymowych W. Cardiovascular and cerebrovascular diseases in ankylosing spondylitis: current insights. Curr Rheumatol Rep 2012; 14 (5): 415-421.
- Huang Y., Wang Y., Pan S. Increased risk of ischemic heart disease in young patients with newly diagnosed ankylosing spondylitis - a population-based longitudinal follow-up study. PLoS One 2013; 8 (5): e64155.
- Bakland G., Gran J., Nossent J. Increased mortality in ankylosing spondylitis is related to desease activity. Ann Rheum Dis 2011; 70: 1921-1925.
![](/img/style/loading.gif)