Tuberculosis in patients with lymphoproliferative diseases


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AIM. To study the clinical manifestations, diagnosis, and treatment of lymphoproliferative diseases (LPD) concurrent with tuberculosis. MATERIALS AND METHODS. In 1990 to 2013, the Hematology Research Center, Ministry of Health of Russia, followed up 4422 patients with LPD. Lymphomas and leukemias were diagnosed using the universally protocols. Tuberculosis was verified by the results of a comprehensive examination involving the histological study of biopsy specimens. RESULTS. Tuberculosis was identified in 85 (2%) patients with LPD. According to the nosological entity, the tuberculosis detection rates were 3% (40/1350) in Hodgkin lymphoma (HL), 1.2% (20/1627) in aggressive lymphomas, 1.4% (16/1136) in mature cell lymphomas and chronic lymphocytic leukemia, and 2.9% (9/309) in hairy cell leukemia. In accordance with its site, pulmonary tuberculosis was 73%; extrapulmonary tuberculosis, 14%; generalized tuberculosis, 12%. In pulmonary tuberculosis, its disseminated and focal involvements were found in 71 and 18% of cases, respectively. Tuberculosis was detected in 43% of the patients with HL in remission; it occurred only in other hemoblastoses in its active phase. When tuberculosis and LPD were simultaneously found, both diseases were concurrently treated. If the chemotherapy of LPD was effective, tuberculosis was cured in all the patients. CONCLUSION. Patients with LPD are a group at increased risk for tuberculosis. The diаgnosis of recurrent LPD must be histologically proven. When tuberculosis and LPD are simultaneously found, both diseases should be concurrently treated.

About the authors

L S Al'-Radi

ФГБУ "Гематологический научный центр" Минздрава России, Москва

Email: lalradi@gmail.com
125167 Москва, Новый Зыковский пр-д, 4

T N Moiseeva

ФГБУ "Гематологический научный центр" Минздрава России, Москва

N G Chernova

ФГБУ "Гематологический научный центр" Минздрава России, Москва

N N Sharkunov

ФГБУ "Гематологический научный центр" Минздрава России, Москва

O V Margolin

ФГБУ "Гематологический научный центр" Минздрава России, Москва

I V Shitareva

ФГБУ "Гематологический научный центр" Минздрава России, Москва

E A Bariakh

ФГБУ "Гематологический научный центр" Минздрава России, Москва

G A Kliasova

ФГБУ "Гематологический научный центр" Минздрава России, Москва

L S Roshchina

ФГБУ "Гематологический научный центр" Минздрава России, Москва

I É Kostina

ФГБУ "Гематологический научный центр" Минздрава России, Москва

S K Kravchenko

ФГБУ "Гематологический научный центр" Минздрава России, Москва

A V Pivnik

ФГБУ "Гематологический научный центр" Минздрава России, Москва

A I Vorob'ev

ФГБУ "Гематологический научный центр" Минздрава России, Москва

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