Email this article Prognostic value of pathogenetic therapy-induced changes in NT-proBNP in patients with chronic heart failure
- Authors: Mezhonov EM1, Shalaev SV1
-
Affiliations:
- "ТюмГМА Росздрава"
- Issue: Vol 84, No 9 (2012)
- Pages: 71-75
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/31122
- ID: 31122
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Abstract
Aim. To study the prognostic value of therapy-induced changes in plasma NT-proBNP levels in patients with left ventricular (LV) systolic dysfunction. Subjects and methods. The study covered 84 patients aged 23 to 70 years (mean 54±8.1 years) with LV systolic dysfunction (an ejection fraction of <40%). Plasma NT-proBNP levels were determined in all the patients at baseline and 3 months later to evaluate the efficiency of therapy for heart failure (HF). The median follow-up was 18 months. The follow-up recorded the following outcomes (end points): death from decompensated HF and unplanned hospital admissions for progressive HF symptoms. Results. The baseline and therapy high plasma levels of NT-proBNP (more than 3000 pg/ml) were associated with worsening prognosis. The therapy-induced decrease in NT-proBNP levels was associated with more favorable prognosis. Conclusion. Repeat dynamic determination of plasma NT-proBNP levels allows identification of patients at increased risk of poor outcomes for a more intensive observation and more aggressive pathogenetic therapy.
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##article.viewOnOriginalSite##About the authors
E M Mezhonov
"ТюмГМА Росздрава"
Email: homunculus@aport.ru
S V Shalaev
"ТюмГМА Росздрава"
Email: Shalaev@tokb.ru
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