The role of leptin, adiponectin and insulin-resistance markers in development of early stages of chronic kidney disease and atherosclerosis of carotid arteries in obese patients

Evgeniya Andreevna Saginova; Сагинова Евгения Андреевна; Marat Gaptelkhakovich Gallyamov; Галлямов Марат Гаптелхакович; Mariya Mikhaylovna Severova; Северова Мария Михайловна; Ol'ga Aleksandrovna Surkova; Суркова Ольга Александровна; Viktor Viktorovich Fomin; Фомин Виктор Викторович; Nikolay Valentinovich Ermakov; Ермаков Николай Валентинович; Alla Valer'evna Rodina; Родина Алла Валерьевна; Nikolay Alekseevich Mukhin; Мухин Николай Алексеевич; E A Saginova; Saginova E A; M G Gallyamov; Gallyamov M G; M M Severova; Severova M M; O A Surkova; Surkova O A; V V Fomin; Fomin V V; N V Ermakov; Ermakov N V; A V Rodina; Rodina A V; N A Mukhin; Mukhin N A

The role of leptin, adiponectin and insulin-resistance markers in development of early stages of chronic kidney disease and atherosclerosis of carotid arteries in obese patients

Authors: Saginova E.A.¹, Gallyamov M.G.², Severova M.M.¹, Surkova O.A.², Fomin V.V.¹, Ermakov N.V.³, Rodina A.V.¹, Mukhin N.A.¹, Saginova EA⁴, Gallyamov MG⁵, Severova MM⁴, Surkova OA⁵, Fomin VV⁴, Ermakov NV⁶, Rodina AV⁴, Mukhin NA⁴
Affiliations:
1. ГОУ ВПО Первый МГМУ им. И. М. Сеченова Минздравсоцразвития
2. МГУ им. М. В. Ломоносова
3. МНИИМЭ РФ
4. I.M. Sechenov First State Moscow Medical University
5. M.V. Lomonosov State Moscow University
6. Moscow Research Institute of Medical Ecology
Issue: Vol 83, No 6 (2011)
Pages: 47-53
Section: Editorial
URL: https://journals.rcsi.science/0040-3660/article/view/30869
ID: 30869

Cite item

Abstract

Aim. To characterize clinicopathogenetically factors influencing development of early chronic kidney disease (CKD) and impairment of other target organs in obese patients.
Material and methods. The examination of 86 obese patients (64 males and 22 females, mean age 44±11 years) included standard clinical tests, test for albuminuria, calculation of glomerular filtration rate (GFR) by MDRD formula, ultrasound investigation of the carotid arteries to detect atherosclerotic lesion of the carotid arteries, assessment of insulin resistance -IR (plasma concentration of insulin before meal and blood C-peptide, HOMA-index), test for plasma adipokinins (leptin, adiponectin).
Results. Significant direct correlations were found between blood plasma leptin concentration, body mass index (BMI), plasma concentration of insulin and C-peptide, HOMA index, adiponectinemia and albuminuria. CKD patients have significantly higher than patients free of CKD levels of IR markers, waist circumference, BMI, leptinemia (38.2±28.8 and 21.6±19.8 ng/ml, respectively; p < 0.01). Obstructive sleep apnea syndrome was associated with higher IR and albuminuria, significantly lower estimated GFR (81±2 and 95±2 ml/min/1.73 m2, respectively; p < 0.05). Ultrasound evidence for atherosclerotic lesions of the carotid arteries was associated with a significant increase in blood plasma concentration of C-peptide, reduction of adiponectinemia (14.9±10.8 and 32.5±22.5 mcg/ml; p < 0.01), a rise in proportion fasting insulinemia/adiponectinemia (1.6±1.2 and 0.6±0.8, respectively; p < 0.05) and reduction of estimated GFR (86±19 and 102±25 ml/min/1.73 m2, respectively; p = 0.001).
Conclusion. In obesity, CKD at early stages develops in parallel with atherosclerotic lesion of the carotid arteries, which correlates with progression of leptinemia, IR and attenuation of organ-protecting properties of adiponectin.