Pilot results of therapy of adult Ph-negative acute lymphoblastic leukemia according to the protocol of Research Group of Russian Hematological Centers ALL-2009

Elena Nikolaevna Parovichnikova; Паровичникова Елена Николаевна; G A Klyasova; Клясова Г А; V G Isaev; Исаев В Г; A N Sokolov; Соколов А Н; A V Kokhno; Кохно А В; V V Troitskaya; Троицкая В В; E V Mavrina; Маврина Е В; E E Khodunova; Ходунова Е Е; E N Ustinova; Устинова Е Н; E O Gribanova; Грибанова Е О; S K Kravchenko; Кравченко С К; V V Ryzhko; Рыжко В В; T S Kaporskaya; Капорская Т С; O Yu Baranova; Баранова О Ю; S N Bondarenko; Бондаренко С Н; A S Nizametdinova; Низаметдинова А С; E V Kondakova; Кондакова Е В; T V Ryl'tsova; Рыльцова Т В; A N Alufer'eva; Алуферьева А Н; O S Samoylova; Самойлова О С; O P Skamorina; Скаморина О П; L V Gavrilova; Гаврилова Л В; A S Pristupa; Приступа А С; N A Vopilina; Вопилина Н А; T S Konstantinova; Константинова Т С; I V Kryuchkova; Крючкова И В; L V Anchukova; Анчукова Л В; T S Tikunova; Тикунова Т С; K D Kaplanov; Капланов К Д; V A Lapin; Лапин В А; V A Tumakov; Тумаков В А; M N Kozmina; Козмина М Н; S A Chernysh; Черныш С А; E I Podol'tseva; Подольцева Э И; S M Kulikov; Куликов С М; Yu R Davidyan; Давидян Ю Р; V G Savchenko; Савченко В Г; E N Parovichnikova; Parovichnikova E N; G A Klyasova; Klyasova G A; V G Isaev; Isaev V G; A N Sokolov; Sokolov A N; A V Kokhno; Kokhno A V; V V Troitskaya; Troitskaya V V; E V Mavrina; Mavrina E V; E E Khodunova; Khodunova E E; E N Ustinova; Ustinova E N; E O Gribanova; Gribanova E O; S K Kravchenko; Kravchenko S K; V V Ryzhko; Ryzhko V V; T S Kaporskaya; Kaporskaya T S; O Yu Baranova; Baranova O Yu; S N Bondarenko; Bondarenko S N; A S Nizametdinova; Nizametdinova A S; E V Kondakova; Kondakova E V; T V Ryltsova; Ryltsova T V; A N Aluferieva; Aluferieva A N; O S Samoilova; Samoilova O S; O P Skamorina; Skamorina O P; L V Gavrilova; Gavrilova L V; A S Pristupa; Pristupa A S; N A Vopilina; Vopilina N A; T S Konstantinova; Konstantinova T S; I V Kryuchkova; Kryuchkova I V; L V Anchukova; Anchukova L V; T S Tikunova; Tikunova T S; K D Kaplanov; Kaplanov K D; V A Lapin; Lapin V A; V A Tumakov; Tumakov V A; M N Kozmina; Kozmina M N; S A Chernysh; Chernysh S A; E I Podoltseva; Podoltseva E I; S M Kulikov; Kulikov S M; Yu R Davidyan; Davidyan Yu R; V G Savchenko; Savchenko V G

Pilot results of therapy of adult Ph-negative acute lymphoblastic leukemia according to the protocol of Research Group of Russian Hematological Centers ALL-2009

Authors: Parovichnikova E.N.¹, Klyasova GA¹, Isaev VG¹, Sokolov AN¹, Kokhno AV¹, Troitskaya VV¹, Mavrina EV¹, Khodunova EE¹, Ustinova EN¹, Gribanova EO¹, Kravchenko SK¹, Ryzhko VV¹, Kaporskaya TS², Baranova OY.³, Bondarenko SN⁴, Nizametdinova AS⁵, Kondakova EV⁶, Ryl'tsova TV⁷, Alufer'eva AN⁸, Samoylova OS⁹, Skamorina OP¹⁰, Gavrilova LV¹¹, Pristupa AS¹², Vopilina NA¹³, Konstantinova TS¹⁴, Kryuchkova IV¹⁵, Anchukova LV¹⁶, Tikunova TS¹⁷, Kaplanov KD¹⁸, Lapin VA¹⁹, Tumakov VA²⁰, Kozmina MN²¹, Chernysh SA²², Podol'tseva EI²³, Kulikov SM¹, Davidyan Y.R¹, Savchenko VG¹, Parovichnikova EN²⁴, Klyasova GA²⁴, Isaev VG²⁴, Sokolov AN²⁴, Kokhno AV²⁴, Troitskaya VV²⁴, Mavrina EV²⁴, Khodunova EE²⁴, Ustinova EN²⁴, Gribanova EO²⁴, Kravchenko SK²⁴, Ryzhko VV²⁴, Kaporskaya TS²⁵, Baranova OY.²⁶, Bondarenko SN²⁷, Nizametdinova AS²⁸, Kondakova EV²⁹, Ryltsova TV³⁰, Aluferieva AN³¹, Samoilova OS³², Skamorina OP³³, Gavrilova LV³⁴, Pristupa AS³⁵, Vopilina NA³⁶, Konstantinova TS³⁷, Kryuchkova IV³⁸, Anchukova LV³⁹, Tikunova TS⁴⁰, Kaplanov KD⁴¹, Lapin VA⁴², Tumakov VA⁴³, Kozmina MN⁴⁴, Chernysh SA⁴⁵, Podoltseva EI⁴⁶, Kulikov SM²⁴, Davidyan Y.R²⁴, Savchenko VG²⁴
Affiliations:
1. Гематологический научный центр Минздравсоцразвития РФ
2. ОКБ, Иркутск
3. РОНЦ им. Н. Н. Блохина РАМН, Москва
4. СПГМУ, Санкт-Петербург
5. ГКБ №17, Санкт-Петербург
6. ОКБ, Сургут
7. ОКБ, Тула
8. ОКБ, Самара
9. ОКБ, Н. Новгород
10. ЦВГ ФСБ, Москва
11. ОКБ, Саранск
12. ОКБ, Рязань
13. ОКБ, Тамбов
14. ОКБ, Екатеринбург
15. НИИКИ РАМН, Новосибирск
16. ОКБ, Вологда
17. ОКБ, Белгород
18. ООД, Волгоград
19. ОКБ, Ярославль
20. ОКБ, Иваново
21. ОКБ, Орел
22. ГКБ им С. П. Боткина, Москва
23. ГКБ № 31, Санкт-Петербург
24. Hematological Research Center, Moscow
25. Regional hospital, Irkutsk
26. N.N. Blokhin Russian Cancer Research Center
27. State Medical University, St-Petersburg
28. City hospital N 17, St-Petersburg
29. Regional hospital, Surgut
30. Regional hospital, Tula
31. Regional hospital, Samara
32. Regional hospital, N. Novgorod
33. Central hospital of GSS, Moscow
34. Regional hospital, Saransk
35. Regional hospital, Ryazan
36. Regional hospital, Tambov
37. Regional hospital, Ekaterinburg
38. Research Clinical Institute, Novosibirsk
39. Regional hospital, Vologda
40. Regional hospital, Belgorod
41. Regional hospital, Volgograd
42. Regional hospital, Yaroslavl
43. Regional hospital, Ivanovo
44. Regional hospital, Orel
45. S.P. Botkin City hospital, Moscow
46. City hospital N 23, St-Petersburg
Issue: Vol 83, No 7 (2011)
Pages: 11-17
Section: Editorial
URL: https://journals.rcsi.science/0040-3660/article/view/30852
ID: 30852

Cite item

Abstract

Aim. To review results of 2-year experience in execution of the protocol on the treatment of adult acute Ph-negative lymphoblastic leukemia ALL-2009.
Material and methods. Of 111 patients registered in the study from November 2008 to December 2010 the analysis covered 96 patients from 23 hematological centers in 18 towns of the RF.
Results. Treatment according to the Protocol ALL-2009 resulted in achievement of a complete remission in 91.2% patients with low early lethality of 5.5%. Postremission lethality fell to 3.7% versus previous studies (22%). Overall 2-year survival and recurrence-free survival reached 77.6 and 78.4%, respectively. Detection of any chromosomic aberrations significantly affected recurrence-free survival: 74 vs 100% in patients with normal karyotype.
Conclusion. Protocol All-2009 demonstrates high efficacy in moderate toxicity and good reproducibility in any hematologic center.

Keywords

adult Ph-negative acute lymphoblastic leukemia, sensitivity to prednisolone, L-asparaginasa

References

Паровичникова Е. Н., Савченко В. Г., Давидян Ю. Р. и др. Итоги лечения острых лимфобластных лейкозов взрослых по протоколу ОЛЛ-2005 как основа для новых исследований. Тер. арх. 2009; 7: 8-16.
Daves M. H., Hunger S., Linda S. B. et al. Longer time to the start of continuation therapy is associated with improved survival in high risk pediatric acute lumphoblastic leukemia(ALL): a report from the Children's Oncology Group (COG). Blood 2010; 116 (21): 1322 , abstr. 3223.
Stive J. I., Buck G., Fielding A. et al. Inability to tolerate standard therapy is a major reason for poor outcome in older adults with acute lymphoblastic leukemia (ALL): results from international MRC/ECOG trial. Blood 2010; 116 (21): 218-219 , abstr. 493.
Goekbuget N., Baumann A., Beck J. et al. PEG-Asparaginase intensification in adult acute lymphoblastic leukemia (ALL): significant improvement of outcome with moderate increase of liver toxicity in the German multicenter study group for adult ALL (GMALL) study 07/2003. Blood 2010; 116 (2l): 219- 220 , abstr. 494.
Rytting M. E., Kantarjian H., Thomas D. A. et al. Adolescent and young adult patients treated with modified augmented Berlin-Frankfurt-Muenster therapy. Blood 2010; 116 (21): 1333, abstr. 3250.
Bassan R., Intermesoli T, Mascuilli A. et al. Pediatric type therapy including lineage-targeted methotrexate to improve eraly minimal residual disease response and survival in adult acute lymphoblastic leukemia (ALL): interim analysis of Northern Italy leukemia group study 10/07. Blood 2010; 116(21): 881- 882, abstr. 2131.

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Pilot results of therapy of adult Ph-negative acute lymphoblastic leukemia according to the protocol of Research Group of Russian Hematological Centers ALL-2009

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