Results of a multicenter trial "Epidemiology of Gastroesophageal Reflux Disease in Russia" (MEGRE)

Leonid Borisovich Lazebnik; Лазебник Леонид Борисович; Antonina Aleksandrovna Masharova; Машарова Антонина Александровна; Dmitriy Stanislavovich Bordin; Бордин Дмитрий Станиславович; Yuriy Vasil'evich Vasil'ev; Васильев Юрий Васильевич; Evgeniy Ivanovich Tkachenko; Ткаченко Евгений Иванович; Rustem Abbasovich Abdulkhakov; Абдулхаков Рустем Аббасович; Mikhail Aleksandrovich Butov; Бутов Михаил Александрович; Elena Yur'evna Eremina; Еремина Елена Юрьевна; Lyudmila Ivanovna Zinchuk; Зинчук Людмила Ивановна; Vladislav Vladimirovich Tsukanov; Цуканов Владислав Владимирович; L B Lazebnik; Lazebnik L B; A A Masharova; Masharova A A; D S Bordin; Bordin D S; Yu V Vasiliev; Vasiliev Yu V; E I Tkachenko; Tkachenko E I; R A Abdulkhakov; Abdulkhakov R A; M A Butov; Butov M A; E Yu Eremina; Eremina E Yu; L I Zinchuk; Zinchuk L I; V V Tsukanov; Tsukanov V V

Results of a multicenter trial "Epidemiology of Gastroesophageal Reflux Disease in Russia" (MEGRE)

Authors: Lazebnik L.B.¹, Masharova A.A.¹, Bordin D.S.¹, Vasil'ev Y.V.¹, Tkachenko E.I.², Abdulkhakov R.A.³, Butov M.A.⁴, Eremina E.Y.⁵, Zinchuk L.I.⁶, Tsukanov V.V.⁷, Lazebnik LB⁸, Masharova AA⁸, Bordin DS⁸, Vasiliev Y.V⁸, Tkachenko EI⁹, Abdulkhakov RA¹⁰, Butov MA¹¹, Eremina EY.¹², Zinchuk LI¹³, Tsukanov VV¹⁴
Affiliations:
1. Центральный научно-исследовательский институт гастроэнтерологии ДЗ Москвы
2. Санкт-Петербургская государственная медицинская академия им. И. И. Мечникова
3. Казанский государственный медицинский университет
4. Рязанский государственный медицинский университет им. И. П. Павлова
5. Мордовский государственный университет им. Н. П. Огарева, Саранск
6. Кемеровская государственная медицинская академия
7. Научно-исследовательский институт медицинских проблем Севера СО РАМН, Красноярск
8. Central Research Gastroenterological Institute, Moscow
9. I.I. Mechnikov St-Petersburg State medical Academy
10. State Medical University, Kazan
11. I.P. Pavlov State Medical University, Ryazan
12. N.P. Ogarev Mordovian State University, Saransk
13. State Medical Academy, Kemerovo
14. Research Institute of North Medical Problems of the Russian Academy of Medical Sciences, Krasnoyarsk
Issue: Vol 83, No 1 (2011)
Pages: 45-50
Section: Editorial
URL: https://journals.rcsi.science/0040-3660/article/view/30789
ID: 30789

Cite item

Abstract

Aim. To assess prevalence of gastroesophageal reflux disease (GERD) in Russia in MEGRE trial in 6 cities of the Russian Federatiion (Kazan, Kemerovo, Krasnoyarsk, Ryazan, St-Petersburg, Saransk).
Material and methods. Mayo Clinic questionnaire (USA) adapted for Russia was used to question 7812 people over 18 years of age from of random population sample. The symptoms (heartburn and regurgitation) were classified as frequent if they arose once a week and more often for the last 12 months, rare symptoms arose less often than once a week. The responders with frequent heartburn and/or regurgitation were regarded as persons with epidemiological quantitative criteria of GERD.
Results. Heartburn occurred in 47.5% responders: frequent in 9%, rare in 38.5%. Regurgitation occurred in 42.9%: frequent in 7.6%, rare in 35.3%. GERD prevalence was 13.3% (city range 11.3-14.3%). Frequent GERD symptoms are associated with frequent gaseous eructation (24.3%), chronic cough (22.9%), chest pain (15.1%), dysphonia (11.4%.). To stop heartburn, 88% responders took antacids, 32% - blockers of histamine H2-receptors and only 23% - inhibitors of proton pump. Only 52.8% responders with frequent chest pain and 29.3% those with frequent hearburn visited a doctor.
Conclusion. The population-based trial MEGRE conducted by international methodology in 6 cities of Russia demonstrated that GERD prevalence is 13.3%. Most of the patients pay little attention to the symptoms, do not seek medical advice and, therefore, receive no adequate treatment.

Keywords

epidemiology, gastroesophageal reflux disease, heartburn

References

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Results of a multicenter trial "Epidemiology of Gastroesophageal Reflux Disease in Russia" (MEGRE)

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