Email this article The survival and sequestration of transfused donor platelets in cytostatic cytopenias
- Authors: Migunova E.V.1, Sakhibov Y.D.1, Ryzhko V.V.1, Sorkina O.M.1, Sagdieva N.S.1, Gemdzhyan E.G.1, Migunova EV2, Sakhibov Y.D2, Ryzhko VV2, Sorkina OM2, Sagdiyeva NS.2, Gemdzhyan EG2
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Affiliations:
- ГУ Гематологический научный центр РАМН
- Hematology Research Center, Russian Academy of Medical Sciences
- Issue: Vol 82, No 12 (2010)
- Pages: 51-56
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/30756
- ID: 30756
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Abstract
Subjects and methods. Seven donor volunteers and 39 patients with different forms with AL at various stages of polychemotherapy (PCT) were examined. Cytostatic therapy was accompanied by 51Cr-labeled platelet concentrate (PC) transfusions. The patients were on appropriate high-dose (HD) PCT.
Results. The duration of donor platelet circulation was 8-10 days in healthy individuals. No platelet hypersequestration was recorded in both the spleen and the liver. Donor platelet survival was shorter in all patients with in a state of cytostatic cytopenia. There was an inverse correlation between the degree of circulation shortening and some clinical and hematological parameters (the bone marrow level of blastemia and blastosis, the XIIa-dependent fibrinolysis parameters). Four variants of radioactivity trends above the spleen and liver were identified. The findings suggest that there is platelet hypersequestration in the spleen, liver, and both organs. In some patients, the above both organs are uninvolved in the hypersequestration processes and the possible mechanism for increased consumption of transfused donor platelets, which is associated with recovery of the HD PCT-damaged vascular endothelium is considered.
Conclusion. Shortening of transfused donor platelet circulation was found in relation to the level of blastosis. The described procedure may be used as one of the additional methods for evaluating the efficacy of donor PC transfusion and for specifying the pathogenesis of thrombocytopenias in AL patients on programmed HD PCT. A procedure is proposed to time the circulation of 51Cr-labeled platelets, by assessing deposit phenomena and estimating the level of their sequestration in the spleen and liver for the prediction of the efficiency of TC transfusions.
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About the authors
Ekaterina Valentinovna Migunova
ГУ Гематологический научный центр РАМН
Email: nuclear@blood.ru
врач-радиолог, радиоизотопная лаб., ГНЦ РАМН, тел.: 8-495-614-92-83; ГУ Гематологический научный центр РАМН
Yashin Daminovich Sakhibov
ГУ Гематологический научный центр РАМН
Email: nuclear@blood.ru
д-р мед. наук, проф., зав. радиоизотопной лаб., ГНЦ РАМН, тел.: 8-495-614-92-83; ГУ Гематологический научный центр РАМН
Vyacheslav Vladimirovich Ryzhko
ГУ Гематологический научный центр РАМНканд. мед. наук, доц., каф. гематологии и интенсивной терапии, Российская медицинская академия последипломного образования, тел.: 8-495-612-15-10; ГУ Гематологический научный центр РАМН
Ol'ga Markovna Sorkina
ГУ Гематологический научный центр РАМНврач-гематолог, отд-ние химиотерапии лейкозов и патологии эритрона, тел.: 8-495-612-43-32; ГУ Гематологический научный центр РАМН
Nadzhiya Shavkatovna Sagdieva
ГУ Гематологический научный центр РАМН
Email: gamma@blood.ru
канд. мед. наук, ст. науч. сотр. радиоизотопной лаб., ГНЦ РАМН, тел.: 8-495-614-92-83; ГУ Гематологический научный центр РАМН
Eduard Georgievich Gemdzhyan
ГУ Гематологический научный центр РАМН
Email: ed366@mail.ru
ст. науч. сотр., лаб. биостатистики и информационных систем, ГНЦ РАМН, тел.: 8-495-613-24-71; ГУ Гематологический научный центр РАМН
E V Migunova
Hematology Research Center, Russian Academy of Medical SciencesHematology Research Center, Russian Academy of Medical Sciences
Ya D Sakhibov
Hematology Research Center, Russian Academy of Medical SciencesHematology Research Center, Russian Academy of Medical Sciences
V V Ryzhko
Hematology Research Center, Russian Academy of Medical SciencesHematology Research Center, Russian Academy of Medical Sciences
O M Sorkina
Hematology Research Center, Russian Academy of Medical SciencesHematology Research Center, Russian Academy of Medical Sciences
N Sh Sagdiyeva
Hematology Research Center, Russian Academy of Medical SciencesHematology Research Center, Russian Academy of Medical Sciences
E G Gemdzhyan
Hematology Research Center, Russian Academy of Medical SciencesHematology Research Center, Russian Academy of Medical Sciences
References
- Воробьев А. И., Бриллиант М. Д., Савченко В. Г. Руководство по гематологии. М.; 2002; т. 1: 201-204.
- Савченко В. Г., Паровичникова Е. Н. Лечение острых лейкозов (Клинические исследования). М.: МЕДпресс-информ; 2004. 224-232.
- Сведенцов Е. П. Переливание концентрата тромбоцитов. В кн.: Руководство по трансфузионной медицине. Киров; 1999. 412-418.
- Сахибов Я. Д. Клиническая эффективность и приживляемость донорских тромбоцитов. В кн.: Сведенцов Е. П. и др. Заготовка и консервирование тромбоцитов для клинического применения. Ташкент: 1996. 76-85.
- Сахибов Я. Д., Сагдиева Н. Ш., Новокщенова Л. В. К вопросу о выживаемости тромбоцитов при некоторых заболеваниях крови. Тер. арх. 1992; 12: 48-51.
- Мигунова Е. В., Сахибов Я. Д., Сагдиева Н. Ш. и др. Радионуклидное 51Cr определение выживаемости и секвестрации облученных донорских тромбоцитов у больных острыми лейкозами. Мед. радиол. 2009; 1, 54(2): 69-72.
- Snyder E. L., Baril L., Corda T. Protocol for 51Cr and 111In radiolabeling of frech blood platelets in vitro. Transfusion 2004; 44: 76A.
- Tsukada T., Tango T. On the methods calculating mean survival time in 51Cr-platelet survival study. Am. J. Hematol. 1980; 8: 281.
- Holme S., Heaton A., Roodt J. Concurrent label method with 111In- and 61Cr allows accurate evaluation of platelet viability of stored platelet concentrates. Br. J. Haematol. 1993; 84: 717- 723.
- Dumontm L. J. Analysis and reporting of platelet kinetic stadies. Transfusion 2006; 46S: 67-73.
- De Vos F. U., Willemse P. H.., De Vries E. G. Endothelial cell effects of cytotoxics: balans between desired and unwanted effects. Cancer Treat. Rev. 2004; 30: 495-513.
- Doll D. C., Yarbro J. W. Vascular toxicity associated with chemotherapy agents. Semin. Oncol. 1992; 19(5): 580-596.
- Баркаган З. С. Нарушения гемостаза при онкогематологических заболеваниях. В кн.: Воробьев А. И. Руководство по гематологии. М.; 2005; т. 3: 129-130.
