Lipoprotein(a) - a new independent cholelithiasis risk factor?
- Authors: Gpigop'eva I.N.1, Tikhonov AV1, Nikitenko TM1, Pyabikov AN1, Nikitin Y.P1, Grigorieva IN1, Tikhonov AV1, Nikitenko TM1, Ryabikov AN1, Nikitin Y.P1
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Affiliations:
- ГУ НИИ терапии СО РАМН
- Issue: Vol 81, No 2 (2009)
- Pages: 54-56
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/30284
- ID: 30284
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Abstract
Material and methods. Examination of the representative samples of 870 females aged 25-64 years and 405 males aged 35-54 years has detected cholelithiasis in 91 females and 19 males.
Results. Serum levels of Lp(a) are associated with cholelithiasis. Risk of the latter in males (Lp(a) > 28 mg/dl) and females (Lp(a) > 24 mg/dl) is estimated. It is confirmed that isoforms of apo(a) B, S1 and S2 in females and isoforms of apo(a) B, S2 in males with cholelithiasis occur much more frequently than in individuals free of cholelithiasis while isoform apo(a) S4 is rare. Females with cholesterol cholelithiasis have positive correlation between blood Lp(a) levels, the presence of isoforms apo(a) B, S1 and bile lithogenicity.
Conclusion. Males and females with cholelithiasis have more frequent high concentrations of Lp(a) (> 30 mg.dl) while low levels (0-5 mg/dl) are rare. There is a correlation between blood levels of Lp(a), apo(a) isoforms, bile lithogenicity in females with cholesterol cholelithiasis.
About the authors
Irina Nikolaevna Gpigop'eva
ГУ НИИ терапии СО РАМНд. м. н., ведущий научный сотрудник, руководитель сектора биохимических аспектов гастроэнтерологии Лаборатории гастроэнтерологии; ГУ НИИ терапии СО РАМН
A V Tikhonov
T M Nikitenko
A N Pyabikov
Yu P Nikitin
I N Grigorieva
A V Tikhonov
T M Nikitenko
A N Ryabikov
Yu P Nikitin
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