Prevalence of subnormal glomerular filtration rate in patients with diabetes mellitus


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Abstract

Aim. To evaluate prevalence of subnormal glomerular filtration rate (GFR) in diabetes mellitus (DM) patients with reference to albuminuria level. Material and methods. GFR by MDRD and urine excretion of protein/albumin were estimated in 851 diabetic patients (473 with type 1 DM and 378 with type 2 DM). Results. Normoalbuminuria (NAU), microalbuminuria (MAU) and proteinuria were detected in 54, 16 and 30% type 1 diabetics, respectively; 77% had subnormal GFR, in NAU 8.3% had GFR decline (<60 ml/min) corresponding to stage III-IV chronic disease of the kidneys. In MAU the latter was present in 16.4%, in proteinuria - in 62.8%. Type 2 diabetics had NAU in 33.6% cases, MAU - in 17.7%, proteinuria - in 48.7%. Subnormal GFR <60 ml/min was found in 40% cases with NAU and MAU. Most patients with proteinuria had chronic disease of the kidneys of stage III-V. In a normal creatinine concentration in blood serum subnormal GFR<60 ml/min was observed in type 1 DM in 7.6, in type 2 DM - in 33% cases. Conclusion. Prevalence of subnormal GFR in diabetic patients with NAU and MAU is rather high. This necessitates wide introduction of this index in screening, follow-up and classification of renal damage severity in DM as well as estimation of albuminuria/proteinuria.

About the authors

I I Trofimenko

Санкт-Петербургский государственный медицинский университет им. акад. И. П. Павлова

V A Dobronravov

Санкт-Петербургский государственный медицинский университет им. акад. И. П. Павлова

N N Bystrova

Санкт-Петербургский государственный медицинский университет им. акад. И. П. Павлова

Iu V Drozdova

Санкт-Петербургский государственный медицинский университет им. акад. И. П. Павлова

O V Galkina

Санкт-Петербургский государственный медицинский университет им. акад. И. П. Павлова

A V Smirnov

Санкт-Петербургский государственный медицинский университет им. акад. И. П. Павлова

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