The test for nitric oxide metabolites in the exhaled aircondensate as a method of assessing NO-reactivity of theairways in patients with bronchial asthma
- Authors: Geltser BI1, Peteshova EE1, Kochetkova EA1, Eliseeva EV1
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Affiliations:
- Владивостокский государственный медицинский университет
- Issue: Vol 78, No 10 (2003)
- Pages: 91-94
- Section: Editorial
- URL: https://journals.rcsi.science/0040-3660/article/view/29690
- ID: 29690
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Full Text
Abstract
clinical forms of bronchial asthma (BA).
Material and methods. The study included 73 patients with BA: mild disease was in 21, moderate in 24 and severe - in 28 patients. Severe BA patients were divided into two subgroups: with a stable
course (n - 15) and unstable course (n = 13). NO-producing function of the airways was estimated
by concentration of stable NO-metabolites (mNO)(N02, N03) in exhaled air condensate.
Results. Spontaneous NO-producing activity of the airways increases and reaches maximum in severe
unstable asthma. Fenoterol-stimulated NO-production was minimal in mild BA while the most significant augmentation of mNO was observed in unstable BA. Basal level of mNO and velocity parameters
of external respiration function correlated.
Conclusion. Estimation of NO-reactivity of the airways in the test with fenoterol with calculation of
the index of airways NO-reactivity provides additional information about respiratory system condition
in BA patients which may be used in clinical pulmonology.
About the authors
B I Geltser
Владивостокский государственный медицинский университетВладивостокский государственный медицинский университет
E E Peteshova
Владивостокский государственный медицинский университетВладивостокский государственный медицинский университет
E A Kochetkova
Владивостокский государственный медицинский университетВладивостокский государственный медицинский университет
E V Eliseeva
Владивостокский государственный медицинский университетВладивостокский государственный медицинский университет
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