Email this article Predictive capability of Cys112Arg single nucleotide polymorphisms of the apolipoprotein E gene in assessing the risk of immediate and early post-traumatic seizures
- Authors: Kriukova K.K.1, Alexandrova E.V.2, Voskresenskaya O.N.1, Podlepich V.V.2, Kravchuk A.D.2, Rytkin E.I.3, Latyshev Y.A.2, Kudlay D.A.1, Sologova S.S.1, Albagachiev S.A.1, Mandrik M.A.1
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Affiliations:
- Sechenov First Moscow State Medical University (Sechenov University)
- Burdenko National Medical Research Center for Neurosurgery
- Northwestern University
- Issue: Vol 95, No 12 (2023)
- Pages: 1128-1132
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/258740
- DOI: https://doi.org/10.26442/00403660.2023.12.202492
- ID: 258740
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Abstract
This study is aimed at investigating epileptic seizures, one of the consequences of traumatic brain injury (TBI). Immediate and early post-traumatic seizures, as well as late post-traumatic epileptic seizures or post-traumatic epilepsy, can have different pathogenetic bases. The following key risk factors associated with post-traumatic epilepsy are known: duration of unconsciousness, gunshot wounds, intracranial hemorrhage, diffuse axonal injury, prolonged (more than 3 days) post-traumatic amnesia, acute subdural hematoma with surgical evacuation, immediate and early post-traumatic epileptic seizures, fracture of the skull bones. The role of genetic factors in post-traumatic seizures is poorly understood due to the complexity and multiple causal mechanisms. This paper addresses the role of genetic factors in the occurrence and severity of epileptic events in patients with TBI. In particular, we investigated the role of the Cys112Arg single nucleotide polymorphism of the apolipoprotein E gene. Apolipoprotein E is known for its role in the transport and metabolism of lipids and, therefore, the development of cardiovascular diseases; it is also associated with Alzheimer's disease and has recently been studied in the context of association with epilepsy. The study shows an association between this polymorphism and the risk of immediate and early epileptic seizures in patients with severe TBI.
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##article.viewOnOriginalSite##About the authors
Kseniia K. Kriukova
Sechenov First Moscow State Medical University (Sechenov University)
Email: ks.k.kryukova@gmail.com
ORCID iD: 0000-0001-6714-9780
аспирант каф. нервных болезней и нейрохирургии
Russian Federation, MoscowEvgenia V. Alexandrova
Burdenko National Medical Research Center for Neurosurgery
Email: ks.k.kryukova@gmail.com
ORCID iD: 0000-0001-5327-314X
канд. мед. наук, врач-невролог
Russian Federation, MoscowOlga N. Voskresenskaya
Sechenov First Moscow State Medical University (Sechenov University)
Email: ks.k.kryukova@gmail.com
ORCID iD: 0000-0002-7330-633X
д-р мед. наук, проф. каф. нервных болезней и нейрохирургии
Russian Federation, MoscowVitaliy V. Podlepich
Burdenko National Medical Research Center for Neurosurgery
Email: ks.k.kryukova@gmail.com
ORCID iD: 0000-0002-3424-3815
канд. мед. наук, врач-реаниматолог
Russian Federation, MoscowAlexander D. Kravchuk
Burdenko National Medical Research Center for Neurosurgery
Author for correspondence.
Email: ks.k.kryukova@gmail.com
ORCID iD: 0000-0002-3112-8256
д-р мед. наук, врач-нейрохирург, зав. отд-нием черепно-мозговой травмы
Russian Federation, MoscowEric I. Rytkin
Northwestern University
Email: ks.k.kryukova@gmail.com
ORCID iD: 0000-0003-2511-0655
докторант, науч. сотр.
United States, ChicagoYaroslav A. Latyshev
Burdenko National Medical Research Center for Neurosurgery
Email: ks.k.kryukova@gmail.com
ORCID iD: 0000-0002-7125-5962
канд. мед. наук, врач-нейрохирург
Russian Federation, MoscowDmitry A. Kudlay
Sechenov First Moscow State Medical University (Sechenov University)
Email: ks.k.kryukova@gmail.com
ORCID iD: 0000-0003-1878-4467
чл.-кор. РАН, д-р мед. наук, проф. каф. фармакологии Института фармации им. А.П. Нелюбина
Russian Federation, MoscowSusanna S. Sologova
Sechenov First Moscow State Medical University (Sechenov University)
Email: ks.k.kryukova@gmail.com
ORCID iD: 0000-0002-8526-7147
канд. биол. наук, доц., зав. учебной частью каф. фармакологии Института фармации им. А.П. Нелюбина
Russian Federation, MoscowSabr A. Albagachiev
Sechenov First Moscow State Medical University (Sechenov University)
Email: ks.k.kryukova@gmail.com
ORCID iD: 0009-0003-5489-7001
ординатор каф. фармацевтической технологии Института фармации им А.П. Нелюбина
Russian Federation, MoscowMark A. Mandrik
Sechenov First Moscow State Medical University (Sechenov University)
Email: ks.k.kryukova@gmail.com
ORCID iD: 0000-0002-3558-9615
ассистент каф. фармацевтической технологии Института фармации им. А.П. Нелюбина
Russian Federation, MoscowReferences
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