Dynamics of hospital mortality in COVID-19 pandemia
- Authors: Gareeva D.F.1, Lakman I.A.2, Agapitov A.A.2, Sadikova L.F.2, Davtian P.A.1, Kayumova V.L.1, Nurtdinova G.M.1, Badykova E.A.1, Kurbanov M.S.1, Idigov I.R.1, Fiedler L.3, Motloch L.4,5,6, Dieplinger А.7, Timiryanova V.M.2, Zagudullin N.S.1
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Affiliations:
- Bashkir State Medical University
- Ufa University of Science and Technology
- Landesklinikum Wiener Neustadt
- Clinic II for Internal Medicine, University Hospital Salzburg, Paracelsus Medical University
- Department of Internal Medicine II, Salzkammergut Klinikum
- Johannes Kepler University, Department of Cardiology, Kepler University Hospital, Medical Faculty
- Institute for Nursing Science and Practice, Paracelsus Medical University
- Issue: Vol 96, No 1 (2024)
- Pages: 29-35
- Section: Original articles
- URL: https://journals.rcsi.science/0040-3660/article/view/258639
- DOI: https://doi.org/10.26442/00403660.2024.01.202558
- ID: 258639
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Abstract
Background. During the pandemic of coronavirus infection (COVID-19) caused by a virus SARS-CoV-2 there has been significant variability in symptoms of the disease over time, severity of the course and in particular hospital mortality. Several SARS-CoV-2 variants have been identified such as Alpha, Delta, Omicron and others.
Aim. To investigate the hospital mortality in patients with different strain variants during the period from April 2020 to April 2022. All included patients had moderate to severe COVID-19-associated pneumonia requiring hospitalization.
Materials and methods. In this retrospective, conclusive, non-randomized, non-controlled study 4854 clinical records of hospitalized patients with Alpha (n=2400, April – December 2020), Delta (n=1722, 2021) and Omicron (n=627, January – April 2022) variants were investigated.
Results. Hospital mortality is 6% in Alpha variant patients (6%), 5.7% in Delta and significantly lower in Omicron (1.5%; p<0,001). Cardiovascular disease (arterial hypertension, coronary heart disease, chronic heart failure), diabetes mellitus and chronic kidney disease were risk factors for death in Alpha and Delta, but not in Omicron. There was also a significant decrease in the duration of hospitalization with strains Delta [7 days (5; 9)] and Omicron [7 (5; 11)] compared with Alpha [11 (9; 13); p<0,001], and differences in factors the risk of mortality between the tested COVID variants.
Conclusion. Thus, differences in mortality and risk factors for death between COVID-19 variants could be shown in our cohort.
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##article.viewOnOriginalSite##About the authors
Diana F. Gareeva
Bashkir State Medical University
Email: d.f.gareeva@mail.ru
ORCID iD: 0000-0002-1874-8661
Scopus Author ID: 56700303400
ResearcherId: G-3941-2016
кандидат медицинских наук, доц. кафедры пропедевтики внутренних болезней
Russian Federation, UfaIrina A. Lakman
Ufa University of Science and Technology
Email: Lackmania@mail.ru
ORCID iD: 0000-0001-9876-9202
кандидат техн. наук, доцент, вед. научный сотрудник управления научных исследований и разработок
Russian Federation, UfaAlexander A. Agapitov
Ufa University of Science and Technology
Email: aleks6321@yandex.ru
ORCID iD: 0000-0002-3618-2657
laboratory researcher of Scientific Research and Development Department
Russian Federation, UfaLiana F. Sadikova
Ufa University of Science and Technology
Email: walsh.lea@gmail.com
ORCID iD: 0000-0001-9250-5548
laboratory researcher of Scientific Research and Development Department
Russian Federation, UfaParuir A. Davtian
Bashkir State Medical University
Email: davtyanparuir@gmail.com
ORCID iD: 0000-0002-5972-6418
postgraduate student at Propaedeutics of internal diseases department
Russian Federation, UfaValeriia L. Kayumova
Bashkir State Medical University
Email: al_val_leon@mail.ru
ORCID iD: 0009-0004-9006-6536
resident at Propaedeutics of internal diseases department
Russian Federation, UfaGuzel M. Nurtdinova
Bashkir State Medical University
Email: guzel-doc@mail.ru
ORCID iD: 0000-0002-1662-821X
MD, Phd, Assosiate professor at Propaedeutics of internal diseases department
Russian Federation, UfaElena A. Badykova
Bashkir State Medical University
Email: lnurova@mail.ru
ORCID iD: 0000-0002-8167-4271
MD, PhD, assistant at Propaedeutics of internal diseases department
Russian Federation, UfaMagomed S. Kurbanov
Bashkir State Medical University
Email: magomedkurbanov10@mail.ru
ORCID iD: 0009-0005-0788-5336
student of the Faculty of Medicine
Russian Federation, UfaIslam R. Idigov
Bashkir State Medical University
Email: nikitakorolev1004@gmail.com
ORCID iD: 0009-0000-4314-3704
student of the Faculty of Medicine
Russian Federation, UfaLukas Fiedler
Landesklinikum Wiener Neustadt
Email: flukas@me.com
ORCID iD: 0000-0003-2626-3098
MD, oberarzt, doctor of medicine, senior physician
Austria, Wiener NeustadtLukas-Jaroslaw Motloch
Clinic II for Internal Medicine, University Hospital Salzburg, Paracelsus Medical University; Department of Internal Medicine II, Salzkammergut Klinikum; Johannes Kepler University, Department of Cardiology, Kepler University Hospital, Medical Faculty
Email: Lukas.Motloch@ooeg.at
ORCID iD: 0000-0002-5829-6743
Dr med, MD., professor, Head of Department of Internal Medicine II, Salzkammergut Klinikum
Austria, Salzburg; Vöcklabruck; LinzАnna-Maria Dieplinger
Institute for Nursing Science and Practice, Paracelsus Medical University
Author for correspondence.
Email: AnnaMaria.Dieplinger@ooeg.at
ORCID iD: 0000-0002-4332-2347
MD, PhD, cooperator
Austria, SalzburgVenera M. Timiryanova
Ufa University of Science and Technology
Email: 79174073127@mail.ru
ORCID iD: 0000-0002-1004-0722
Leading researcher of Scientific Research and Development Department
Russian Federation, UfaNaufal Sh. Zagudullin
Bashkir State Medical University
Email: znaufal@mail.ru
ORCID iD: 0000-0003-2386-6707
Doctor of Medical Sciences, Professor, Phd, MD, Director of the Research Institute of Cardiology, Head of the Department of Propaedeutics of Internal Diseases
Russian Federation, UfaReferences
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